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CFEA: a cell-free epigenome atlas in human diseases
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| Zeitschriftentitel: | Nucleic Acids Research |
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| Personen und Körperschaften: | , , , , , , , , , , |
| In: | Nucleic Acids Research, 48, 2020, D1, S. D40-D44 |
| Medientyp: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
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| Schlagwörter: |
| author_facet |
Yu, Fulong Li, Kai Li, Shuangquan Liu, Jiaqi Zhang, Yan Zhou, Meng Zhao, Hengqiang Chen, Hongyan Wu, Nan Liu, Zhihua Su, Jianzhong Yu, Fulong Li, Kai Li, Shuangquan Liu, Jiaqi Zhang, Yan Zhou, Meng Zhao, Hengqiang Chen, Hongyan Wu, Nan Liu, Zhihua Su, Jianzhong |
|---|---|
| author |
Yu, Fulong Li, Kai Li, Shuangquan Liu, Jiaqi Zhang, Yan Zhou, Meng Zhao, Hengqiang Chen, Hongyan Wu, Nan Liu, Zhihua Su, Jianzhong |
| spellingShingle |
Yu, Fulong Li, Kai Li, Shuangquan Liu, Jiaqi Zhang, Yan Zhou, Meng Zhao, Hengqiang Chen, Hongyan Wu, Nan Liu, Zhihua Su, Jianzhong Nucleic Acids Research CFEA: a cell-free epigenome atlas in human diseases Genetics |
| author_sort |
yu, fulong |
| spelling |
Yu, Fulong Li, Kai Li, Shuangquan Liu, Jiaqi Zhang, Yan Zhou, Meng Zhao, Hengqiang Chen, Hongyan Wu, Nan Liu, Zhihua Su, Jianzhong 0305-1048 1362-4962 Oxford University Press (OUP) Genetics http://dx.doi.org/10.1093/nar/gkz715 <jats:title>Abstract</jats:title><jats:p>Epigenetic alterations, including 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and nucleosome positioning (NP), in cell-free DNA (cfDNA) have been widely observed in human diseases, and many available cfDNA-based epigenome-wide profiles exhibit high sensitivity and specificity in disease detection and classification. However, due to the lack of efficient collection, standardized quality control, and analysis procedures, efficiently integrating and reusing these data remain considerable challenges. Here, we introduce CFEA (http://www.bio-data.cn/CFEA), a cell-free epigenome database dedicated to three types of widely adopted epigenetic modifications (5mC, 5hmC and NP) involved in 27 human diseases. We developed bioinformatic pipelines for quality control and standard data processing and an easy-to-use web interface to facilitate the query, visualization and download of these cell-free epigenome data. We also manually curated related biological and clinical information for each profile, allowing users to better browse and compare cfDNA epigenomes at a specific stage (such as early- or metastasis-stage) of cancer development. CFEA provides a comprehensive and timely resource to the scientific community and supports the development of liquid biopsy-based biomarkers for various human diseases.</jats:p> CFEA: a cell-free epigenome atlas in human diseases Nucleic Acids Research |
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Oxford University Press (OUP), 2020 |
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| title |
CFEA: a cell-free epigenome atlas in human diseases |
| title_unstemmed |
CFEA: a cell-free epigenome atlas in human diseases |
| title_full |
CFEA: a cell-free epigenome atlas in human diseases |
| title_fullStr |
CFEA: a cell-free epigenome atlas in human diseases |
| title_full_unstemmed |
CFEA: a cell-free epigenome atlas in human diseases |
| title_short |
CFEA: a cell-free epigenome atlas in human diseases |
| title_sort |
cfea: a cell-free epigenome atlas in human diseases |
| topic |
Genetics |
| url |
http://dx.doi.org/10.1093/nar/gkz715 |
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2020 |
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D40-D44 |
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<jats:title>Abstract</jats:title><jats:p>Epigenetic alterations, including 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and nucleosome positioning (NP), in cell-free DNA (cfDNA) have been widely observed in human diseases, and many available cfDNA-based epigenome-wide profiles exhibit high sensitivity and specificity in disease detection and classification. However, due to the lack of efficient collection, standardized quality control, and analysis procedures, efficiently integrating and reusing these data remain considerable challenges. Here, we introduce CFEA (http://www.bio-data.cn/CFEA), a cell-free epigenome database dedicated to three types of widely adopted epigenetic modifications (5mC, 5hmC and NP) involved in 27 human diseases. We developed bioinformatic pipelines for quality control and standard data processing and an easy-to-use web interface to facilitate the query, visualization and download of these cell-free epigenome data. We also manually curated related biological and clinical information for each profile, allowing users to better browse and compare cfDNA epigenomes at a specific stage (such as early- or metastasis-stage) of cancer development. CFEA provides a comprehensive and timely resource to the scientific community and supports the development of liquid biopsy-based biomarkers for various human diseases.</jats:p> |
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| author | Yu, Fulong, Li, Kai, Li, Shuangquan, Liu, Jiaqi, Zhang, Yan, Zhou, Meng, Zhao, Hengqiang, Chen, Hongyan, Wu, Nan, Liu, Zhihua, Su, Jianzhong |
| author_facet | Yu, Fulong, Li, Kai, Li, Shuangquan, Liu, Jiaqi, Zhang, Yan, Zhou, Meng, Zhao, Hengqiang, Chen, Hongyan, Wu, Nan, Liu, Zhihua, Su, Jianzhong, Yu, Fulong, Li, Kai, Li, Shuangquan, Liu, Jiaqi, Zhang, Yan, Zhou, Meng, Zhao, Hengqiang, Chen, Hongyan, Wu, Nan, Liu, Zhihua, Su, Jianzhong |
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| description | <jats:title>Abstract</jats:title><jats:p>Epigenetic alterations, including 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and nucleosome positioning (NP), in cell-free DNA (cfDNA) have been widely observed in human diseases, and many available cfDNA-based epigenome-wide profiles exhibit high sensitivity and specificity in disease detection and classification. However, due to the lack of efficient collection, standardized quality control, and analysis procedures, efficiently integrating and reusing these data remain considerable challenges. Here, we introduce CFEA (http://www.bio-data.cn/CFEA), a cell-free epigenome database dedicated to three types of widely adopted epigenetic modifications (5mC, 5hmC and NP) involved in 27 human diseases. We developed bioinformatic pipelines for quality control and standard data processing and an easy-to-use web interface to facilitate the query, visualization and download of these cell-free epigenome data. We also manually curated related biological and clinical information for each profile, allowing users to better browse and compare cfDNA epigenomes at a specific stage (such as early- or metastasis-stage) of cancer development. CFEA provides a comprehensive and timely resource to the scientific community and supports the development of liquid biopsy-based biomarkers for various human diseases.</jats:p> |
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| spelling | Yu, Fulong Li, Kai Li, Shuangquan Liu, Jiaqi Zhang, Yan Zhou, Meng Zhao, Hengqiang Chen, Hongyan Wu, Nan Liu, Zhihua Su, Jianzhong 0305-1048 1362-4962 Oxford University Press (OUP) Genetics http://dx.doi.org/10.1093/nar/gkz715 <jats:title>Abstract</jats:title><jats:p>Epigenetic alterations, including 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and nucleosome positioning (NP), in cell-free DNA (cfDNA) have been widely observed in human diseases, and many available cfDNA-based epigenome-wide profiles exhibit high sensitivity and specificity in disease detection and classification. However, due to the lack of efficient collection, standardized quality control, and analysis procedures, efficiently integrating and reusing these data remain considerable challenges. Here, we introduce CFEA (http://www.bio-data.cn/CFEA), a cell-free epigenome database dedicated to three types of widely adopted epigenetic modifications (5mC, 5hmC and NP) involved in 27 human diseases. We developed bioinformatic pipelines for quality control and standard data processing and an easy-to-use web interface to facilitate the query, visualization and download of these cell-free epigenome data. We also manually curated related biological and clinical information for each profile, allowing users to better browse and compare cfDNA epigenomes at a specific stage (such as early- or metastasis-stage) of cancer development. CFEA provides a comprehensive and timely resource to the scientific community and supports the development of liquid biopsy-based biomarkers for various human diseases.</jats:p> CFEA: a cell-free epigenome atlas in human diseases Nucleic Acids Research |
| spellingShingle | Yu, Fulong, Li, Kai, Li, Shuangquan, Liu, Jiaqi, Zhang, Yan, Zhou, Meng, Zhao, Hengqiang, Chen, Hongyan, Wu, Nan, Liu, Zhihua, Su, Jianzhong, Nucleic Acids Research, CFEA: a cell-free epigenome atlas in human diseases, Genetics |
| title | CFEA: a cell-free epigenome atlas in human diseases |
| title_full | CFEA: a cell-free epigenome atlas in human diseases |
| title_fullStr | CFEA: a cell-free epigenome atlas in human diseases |
| title_full_unstemmed | CFEA: a cell-free epigenome atlas in human diseases |
| title_short | CFEA: a cell-free epigenome atlas in human diseases |
| title_sort | cfea: a cell-free epigenome atlas in human diseases |
| title_unstemmed | CFEA: a cell-free epigenome atlas in human diseases |
| topic | Genetics |
| url | http://dx.doi.org/10.1093/nar/gkz715 |