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Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration

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Bibliographische Detailangaben
Zeitschriftentitel: Advanced Healthcare Materials
Personen und Körperschaften: Tong, Xinming, Yang, Fan
In: Advanced Healthcare Materials, 7, 2018, 7
Medientyp: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
author_facet Tong, Xinming
Yang, Fan
Tong, Xinming
Yang, Fan
author Tong, Xinming
Yang, Fan
spellingShingle Tong, Xinming
Yang, Fan
Advanced Healthcare Materials
Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
Pharmaceutical Science
Biomedical Engineering
Biomaterials
author_sort tong, xinming
spelling Tong, Xinming Yang, Fan 2192-2640 2192-2659 Wiley Pharmaceutical Science Biomedical Engineering Biomaterials http://dx.doi.org/10.1002/adhm.201701065 <jats:title>Abstract</jats:title><jats:p>Biomaterials are key factors in regenerative medicine. Matrices used for cell delivery are especially important, as they provide support to transplanted cells that is essential for promoting cell survival, retention, and desirable phenotypes. Injectable matrices have become promising and attractive due to their minimum invasiveness and ease of use. Conventional injectable matrices mostly use hydrogel precursor solutions that form solid, cell‐laden hydrogel scaffolds in situ. However, these materials are associated with challenges in biocompatibility, shear‐induced cell death, lack of control over cellular phenotype, lack of macroporosity and remodeling, and relatively weak mechanical strength. This Progress Report provides a brief overview of recent progress in developing injectable matrices to overcome the limitations of conventional in situ hydrogels. Biocompatible chemistry and shear‐thinning hydrogels have been introduced to promote cell survival and retention. Emerging investigations of the effects of matrix properties on cellular function in 3D provide important guidelines for promoting desirable cellular phenotypes. Moreover, several novel approaches are combining injectability with macroporosity to achieve macroporous, injectable matrices for cell delivery.</jats:p> Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration Advanced Healthcare Materials
doi_str_mv 10.1002/adhm.201701065
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title Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
title_unstemmed Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
title_full Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
title_fullStr Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
title_full_unstemmed Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
title_short Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
title_sort recent progress in developing injectable matrices for enhancing cell delivery and tissue regeneration
topic Pharmaceutical Science
Biomedical Engineering
Biomaterials
url http://dx.doi.org/10.1002/adhm.201701065
publishDate 2018
physical
description <jats:title>Abstract</jats:title><jats:p>Biomaterials are key factors in regenerative medicine. Matrices used for cell delivery are especially important, as they provide support to transplanted cells that is essential for promoting cell survival, retention, and desirable phenotypes. Injectable matrices have become promising and attractive due to their minimum invasiveness and ease of use. Conventional injectable matrices mostly use hydrogel precursor solutions that form solid, cell‐laden hydrogel scaffolds in situ. However, these materials are associated with challenges in biocompatibility, shear‐induced cell death, lack of control over cellular phenotype, lack of macroporosity and remodeling, and relatively weak mechanical strength. This Progress Report provides a brief overview of recent progress in developing injectable matrices to overcome the limitations of conventional in situ hydrogels. Biocompatible chemistry and shear‐thinning hydrogels have been introduced to promote cell survival and retention. Emerging investigations of the effects of matrix properties on cellular function in 3D provide important guidelines for promoting desirable cellular phenotypes. Moreover, several novel approaches are combining injectability with macroporosity to achieve macroporous, injectable matrices for cell delivery.</jats:p>
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author Tong, Xinming, Yang, Fan
author_facet Tong, Xinming, Yang, Fan, Tong, Xinming, Yang, Fan
author_sort tong, xinming
container_issue 7
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description <jats:title>Abstract</jats:title><jats:p>Biomaterials are key factors in regenerative medicine. Matrices used for cell delivery are especially important, as they provide support to transplanted cells that is essential for promoting cell survival, retention, and desirable phenotypes. Injectable matrices have become promising and attractive due to their minimum invasiveness and ease of use. Conventional injectable matrices mostly use hydrogel precursor solutions that form solid, cell‐laden hydrogel scaffolds in situ. However, these materials are associated with challenges in biocompatibility, shear‐induced cell death, lack of control over cellular phenotype, lack of macroporosity and remodeling, and relatively weak mechanical strength. This Progress Report provides a brief overview of recent progress in developing injectable matrices to overcome the limitations of conventional in situ hydrogels. Biocompatible chemistry and shear‐thinning hydrogels have been introduced to promote cell survival and retention. Emerging investigations of the effects of matrix properties on cellular function in 3D provide important guidelines for promoting desirable cellular phenotypes. Moreover, several novel approaches are combining injectability with macroporosity to achieve macroporous, injectable matrices for cell delivery.</jats:p>
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spelling Tong, Xinming Yang, Fan 2192-2640 2192-2659 Wiley Pharmaceutical Science Biomedical Engineering Biomaterials http://dx.doi.org/10.1002/adhm.201701065 <jats:title>Abstract</jats:title><jats:p>Biomaterials are key factors in regenerative medicine. Matrices used for cell delivery are especially important, as they provide support to transplanted cells that is essential for promoting cell survival, retention, and desirable phenotypes. Injectable matrices have become promising and attractive due to their minimum invasiveness and ease of use. Conventional injectable matrices mostly use hydrogel precursor solutions that form solid, cell‐laden hydrogel scaffolds in situ. However, these materials are associated with challenges in biocompatibility, shear‐induced cell death, lack of control over cellular phenotype, lack of macroporosity and remodeling, and relatively weak mechanical strength. This Progress Report provides a brief overview of recent progress in developing injectable matrices to overcome the limitations of conventional in situ hydrogels. Biocompatible chemistry and shear‐thinning hydrogels have been introduced to promote cell survival and retention. Emerging investigations of the effects of matrix properties on cellular function in 3D provide important guidelines for promoting desirable cellular phenotypes. Moreover, several novel approaches are combining injectability with macroporosity to achieve macroporous, injectable matrices for cell delivery.</jats:p> Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration Advanced Healthcare Materials
spellingShingle Tong, Xinming, Yang, Fan, Advanced Healthcare Materials, Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration, Pharmaceutical Science, Biomedical Engineering, Biomaterials
title Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
title_full Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
title_fullStr Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
title_full_unstemmed Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
title_short Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
title_sort recent progress in developing injectable matrices for enhancing cell delivery and tissue regeneration
title_unstemmed Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration
topic Pharmaceutical Science, Biomedical Engineering, Biomaterials
url http://dx.doi.org/10.1002/adhm.201701065