Eintrag weiter verarbeiten
Buchumschlag von A longitudinal approach to biological psychiatric research: The PsyCourse study
Verfügbar über Online-Ressource

A longitudinal approach to biological psychiatric research: The PsyCourse study

Gespeichert in:

Bibliographische Detailangaben
Zeitschriftentitel: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Personen und Körperschaften: Budde, Monika, Anderson‐Schmidt, Heike, Gade, Katrin, Reich‐Erkelenz, Daniela, Adorjan, Kristina, Kalman, Janos L., Senner, Fanny, Papiol, Sergi, Andlauer, Till F. M., Comes, Ashley L., Schulte, Eva C., Klöhn‐Saghatolislam, Farah, Gryaznova, Anna, Hake, Maria, Bartholdi, Kim, Flatau, Laura, Reitt, Markus, Quast, Silke, Stegmaier, Sophia, Meyers, Milena, Emons, Barbara, Haußleiter, Ida Sybille, Juckel, Georg, Nieratschker, Vanessa, Dannlowski, Udo, Schaupp, Sabrina K., Schmauß, Max, Zimmermann, Jörg, Reimer, Jens, Schulz, Sybille, Wiltfang, Jens, Reininghaus, Eva, Anghelescu, Ion‐George, Arolt, Volker, Baune, Bernhard T., Konrad, Carsten, Thiel, Andreas, Fallgatter, Andreas J., Figge, Christian, von Hagen, Martin, Koller, Manfred, Lang, Fabian U., Wigand, Moritz E., Becker, Thomas, Jäger, Markus, Dietrich, Detlef E., Stierl, Sebastian, Scherk, Harald, Spitzer, Carsten, Folkerts, Here, Witt, Stephanie H., Degenhardt, Franziska, Forstner, Andreas J., Rietschel, Marcella, Nöthen, Markus M., Falkai, Peter, Schulze, Thomas G., Heilbronner, Urs
In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180, 2019, 2, S. 89-102
Medientyp: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
author_facet Budde, Monika
Anderson‐Schmidt, Heike
Gade, Katrin
Reich‐Erkelenz, Daniela
Adorjan, Kristina
Kalman, Janos L.
Senner, Fanny
Papiol, Sergi
Andlauer, Till F. M.
Comes, Ashley L.
Schulte, Eva C.
Klöhn‐Saghatolislam, Farah
Gryaznova, Anna
Hake, Maria
Bartholdi, Kim
Flatau, Laura
Reitt, Markus
Quast, Silke
Stegmaier, Sophia
Meyers, Milena
Emons, Barbara
Haußleiter, Ida Sybille
Juckel, Georg
Nieratschker, Vanessa
Dannlowski, Udo
Schaupp, Sabrina K.
Schmauß, Max
Zimmermann, Jörg
Reimer, Jens
Schulz, Sybille
Wiltfang, Jens
Reininghaus, Eva
Anghelescu, Ion‐George
Arolt, Volker
Baune, Bernhard T.
Konrad, Carsten
Thiel, Andreas
Fallgatter, Andreas J.
Figge, Christian
von Hagen, Martin
Koller, Manfred
Lang, Fabian U.
Wigand, Moritz E.
Becker, Thomas
Jäger, Markus
Dietrich, Detlef E.
Stierl, Sebastian
Scherk, Harald
Spitzer, Carsten
Folkerts, Here
Witt, Stephanie H.
Degenhardt, Franziska
Forstner, Andreas J.
Rietschel, Marcella
Nöthen, Markus M.
Falkai, Peter
Schulze, Thomas G.
Heilbronner, Urs
Budde, Monika
Anderson‐Schmidt, Heike
Gade, Katrin
Reich‐Erkelenz, Daniela
Adorjan, Kristina
Kalman, Janos L.
Senner, Fanny
Papiol, Sergi
Andlauer, Till F. M.
Comes, Ashley L.
Schulte, Eva C.
Klöhn‐Saghatolislam, Farah
Gryaznova, Anna
Hake, Maria
Bartholdi, Kim
Flatau, Laura
Reitt, Markus
Quast, Silke
Stegmaier, Sophia
Meyers, Milena
Emons, Barbara
Haußleiter, Ida Sybille
Juckel, Georg
Nieratschker, Vanessa
Dannlowski, Udo
Schaupp, Sabrina K.
Schmauß, Max
Zimmermann, Jörg
Reimer, Jens
Schulz, Sybille
Wiltfang, Jens
Reininghaus, Eva
Anghelescu, Ion‐George
Arolt, Volker
Baune, Bernhard T.
Konrad, Carsten
Thiel, Andreas
Fallgatter, Andreas J.
Figge, Christian
von Hagen, Martin
Koller, Manfred
Lang, Fabian U.
Wigand, Moritz E.
Becker, Thomas
Jäger, Markus
Dietrich, Detlef E.
Stierl, Sebastian
Scherk, Harald
Spitzer, Carsten
Folkerts, Here
Witt, Stephanie H.
Degenhardt, Franziska
Forstner, Andreas J.
Rietschel, Marcella
Nöthen, Markus M.
Falkai, Peter
Schulze, Thomas G.
Heilbronner, Urs
author Budde, Monika
Anderson‐Schmidt, Heike
Gade, Katrin
Reich‐Erkelenz, Daniela
Adorjan, Kristina
Kalman, Janos L.
Senner, Fanny
Papiol, Sergi
Andlauer, Till F. M.
Comes, Ashley L.
Schulte, Eva C.
Klöhn‐Saghatolislam, Farah
Gryaznova, Anna
Hake, Maria
Bartholdi, Kim
Flatau, Laura
Reitt, Markus
Quast, Silke
Stegmaier, Sophia
Meyers, Milena
Emons, Barbara
Haußleiter, Ida Sybille
Juckel, Georg
Nieratschker, Vanessa
Dannlowski, Udo
Schaupp, Sabrina K.
Schmauß, Max
Zimmermann, Jörg
Reimer, Jens
Schulz, Sybille
Wiltfang, Jens
Reininghaus, Eva
Anghelescu, Ion‐George
Arolt, Volker
Baune, Bernhard T.
Konrad, Carsten
Thiel, Andreas
Fallgatter, Andreas J.
Figge, Christian
von Hagen, Martin
Koller, Manfred
Lang, Fabian U.
Wigand, Moritz E.
Becker, Thomas
Jäger, Markus
Dietrich, Detlef E.
Stierl, Sebastian
Scherk, Harald
Spitzer, Carsten
Folkerts, Here
Witt, Stephanie H.
Degenhardt, Franziska
Forstner, Andreas J.
Rietschel, Marcella
Nöthen, Markus M.
Falkai, Peter
Schulze, Thomas G.
Heilbronner, Urs
spellingShingle Budde, Monika
Anderson‐Schmidt, Heike
Gade, Katrin
Reich‐Erkelenz, Daniela
Adorjan, Kristina
Kalman, Janos L.
Senner, Fanny
Papiol, Sergi
Andlauer, Till F. M.
Comes, Ashley L.
Schulte, Eva C.
Klöhn‐Saghatolislam, Farah
Gryaznova, Anna
Hake, Maria
Bartholdi, Kim
Flatau, Laura
Reitt, Markus
Quast, Silke
Stegmaier, Sophia
Meyers, Milena
Emons, Barbara
Haußleiter, Ida Sybille
Juckel, Georg
Nieratschker, Vanessa
Dannlowski, Udo
Schaupp, Sabrina K.
Schmauß, Max
Zimmermann, Jörg
Reimer, Jens
Schulz, Sybille
Wiltfang, Jens
Reininghaus, Eva
Anghelescu, Ion‐George
Arolt, Volker
Baune, Bernhard T.
Konrad, Carsten
Thiel, Andreas
Fallgatter, Andreas J.
Figge, Christian
von Hagen, Martin
Koller, Manfred
Lang, Fabian U.
Wigand, Moritz E.
Becker, Thomas
Jäger, Markus
Dietrich, Detlef E.
Stierl, Sebastian
Scherk, Harald
Spitzer, Carsten
Folkerts, Here
Witt, Stephanie H.
Degenhardt, Franziska
Forstner, Andreas J.
Rietschel, Marcella
Nöthen, Markus M.
Falkai, Peter
Schulze, Thomas G.
Heilbronner, Urs
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A longitudinal approach to biological psychiatric research: The PsyCourse study
Cellular and Molecular Neuroscience
Psychiatry and Mental health
Genetics (clinical)
author_sort budde, monika
spelling Budde, Monika Anderson‐Schmidt, Heike Gade, Katrin Reich‐Erkelenz, Daniela Adorjan, Kristina Kalman, Janos L. Senner, Fanny Papiol, Sergi Andlauer, Till F. M. Comes, Ashley L. Schulte, Eva C. Klöhn‐Saghatolislam, Farah Gryaznova, Anna Hake, Maria Bartholdi, Kim Flatau, Laura Reitt, Markus Quast, Silke Stegmaier, Sophia Meyers, Milena Emons, Barbara Haußleiter, Ida Sybille Juckel, Georg Nieratschker, Vanessa Dannlowski, Udo Schaupp, Sabrina K. Schmauß, Max Zimmermann, Jörg Reimer, Jens Schulz, Sybille Wiltfang, Jens Reininghaus, Eva Anghelescu, Ion‐George Arolt, Volker Baune, Bernhard T. Konrad, Carsten Thiel, Andreas Fallgatter, Andreas J. Figge, Christian von Hagen, Martin Koller, Manfred Lang, Fabian U. Wigand, Moritz E. Becker, Thomas Jäger, Markus Dietrich, Detlef E. Stierl, Sebastian Scherk, Harald Spitzer, Carsten Folkerts, Here Witt, Stephanie H. Degenhardt, Franziska Forstner, Andreas J. Rietschel, Marcella Nöthen, Markus M. Falkai, Peter Schulze, Thomas G. Heilbronner, Urs 1552-4841 1552-485X Wiley Cellular and Molecular Neuroscience Psychiatry and Mental health Genetics (clinical) http://dx.doi.org/10.1002/ajmg.b.32639 <jats:p>In current diagnostic systems, schizophrenia and bipolar disorder are still conceptualized as distinct categorical entities. Recently, both clinical and genomic evidence have challenged this Kraepelinian dichotomy. There are only few longitudinal studies addressing potential overlaps between these conditions. Here, we present design and first results of the PsyCourse study (<jats:italic>N</jats:italic> = 891 individuals at baseline), an ongoing transdiagnostic study of the affective‐to‐psychotic continuum that combines longitudinal deep phenotyping and dimensional assessment of psychopathology with an extensive collection of biomaterial. To provide an initial characterization of the PsyCourse study sample, we compare two broad diagnostic groups defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM‐IV) classification system, that is, predominantly affective (<jats:italic>n</jats:italic> = 367 individuals) versus predominantly psychotic disorders (<jats:italic>n</jats:italic> = 524 individuals). Depressive, manic, and psychotic symptoms as well as global functioning over time were contrasted using linear mixed models. Furthermore, we explored the effects of polygenic risk scores for schizophrenia on diagnostic group membership and addressed their effects on nonparticipation in follow‐up visits. While phenotypic results confirmed expected differences in current psychotic symptoms and global functioning, both manic and depressive symptoms did not vary between both groups after correction for multiple testing. Polygenic risk scores for schizophrenia significantly explained part of the variability of diagnostic group. The PsyCourse study presents a unique resource to research the complex relationships of psychopathology and biology in severe mental disorders not confined to traditional diagnostic boundaries and is open for collaborations.</jats:p> A longitudinal approach to biological psychiatric research: The PsyCourse study American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
doi_str_mv 10.1002/ajmg.b.32639
facet_avail Online
finc_class_facet Biologie
Psychologie
Medizin
format ElectronicArticle
fullrecord blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9ham1nLmIuMzI2Mzk
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9ham1nLmIuMzI2Mzk
institution DE-Gla1
DE-Zi4
DE-15
DE-Pl11
DE-Rs1
DE-105
DE-14
DE-Ch1
DE-L229
DE-D275
DE-Bn3
DE-Brt1
DE-D161
imprint Wiley, 2019
imprint_str_mv Wiley, 2019
issn 1552-4841
1552-485X
issn_str_mv 1552-4841
1552-485X
language English
mega_collection Wiley (CrossRef)
match_str budde2019alongitudinalapproachtobiologicalpsychiatricresearchthepsycoursestudy
publishDateSort 2019
publisher Wiley
recordtype ai
record_format ai
series American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
source_id 49
title A longitudinal approach to biological psychiatric research: The PsyCourse study
title_unstemmed A longitudinal approach to biological psychiatric research: The PsyCourse study
title_full A longitudinal approach to biological psychiatric research: The PsyCourse study
title_fullStr A longitudinal approach to biological psychiatric research: The PsyCourse study
title_full_unstemmed A longitudinal approach to biological psychiatric research: The PsyCourse study
title_short A longitudinal approach to biological psychiatric research: The PsyCourse study
title_sort a longitudinal approach to biological psychiatric research: the psycourse study
topic Cellular and Molecular Neuroscience
Psychiatry and Mental health
Genetics (clinical)
url http://dx.doi.org/10.1002/ajmg.b.32639
publishDate 2019
physical 89-102
description <jats:p>In current diagnostic systems, schizophrenia and bipolar disorder are still conceptualized as distinct categorical entities. Recently, both clinical and genomic evidence have challenged this Kraepelinian dichotomy. There are only few longitudinal studies addressing potential overlaps between these conditions. Here, we present design and first results of the PsyCourse study (<jats:italic>N</jats:italic> = 891 individuals at baseline), an ongoing transdiagnostic study of the affective‐to‐psychotic continuum that combines longitudinal deep phenotyping and dimensional assessment of psychopathology with an extensive collection of biomaterial. To provide an initial characterization of the PsyCourse study sample, we compare two broad diagnostic groups defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM‐IV) classification system, that is, predominantly affective (<jats:italic>n</jats:italic> = 367 individuals) versus predominantly psychotic disorders (<jats:italic>n</jats:italic> = 524 individuals). Depressive, manic, and psychotic symptoms as well as global functioning over time were contrasted using linear mixed models. Furthermore, we explored the effects of polygenic risk scores for schizophrenia on diagnostic group membership and addressed their effects on nonparticipation in follow‐up visits. While phenotypic results confirmed expected differences in current psychotic symptoms and global functioning, both manic and depressive symptoms did not vary between both groups after correction for multiple testing. Polygenic risk scores for schizophrenia significantly explained part of the variability of diagnostic group. The PsyCourse study presents a unique resource to research the complex relationships of psychopathology and biology in severe mental disorders not confined to traditional diagnostic boundaries and is open for collaborations.</jats:p>
container_issue 2
container_start_page 89
container_title American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
container_volume 180
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
_version_ 1792348105312567309
geogr_code not assigned
last_indexed 2024-03-01T18:05:05.552Z
geogr_code_person not assigned
openURL url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=A+longitudinal+approach+to+biological+psychiatric+research%3A+The+PsyCourse+study&rft.date=2019-03-01&genre=article&issn=1552-485X&volume=180&issue=2&spage=89&epage=102&pages=89-102&jtitle=American+Journal+of+Medical+Genetics+Part+B%3A+Neuropsychiatric+Genetics&atitle=A+longitudinal+approach+to+biological+psychiatric+research%3A+The+PsyCourse+study&aulast=Heilbronner&aufirst=Urs&rft_id=info%3Adoi%2F10.1002%2Fajmg.b.32639&rft.language%5B0%5D=eng
SOLR
_version_ 1792348105312567309
author Budde, Monika, Anderson‐Schmidt, Heike, Gade, Katrin, Reich‐Erkelenz, Daniela, Adorjan, Kristina, Kalman, Janos L., Senner, Fanny, Papiol, Sergi, Andlauer, Till F. M., Comes, Ashley L., Schulte, Eva C., Klöhn‐Saghatolislam, Farah, Gryaznova, Anna, Hake, Maria, Bartholdi, Kim, Flatau, Laura, Reitt, Markus, Quast, Silke, Stegmaier, Sophia, Meyers, Milena, Emons, Barbara, Haußleiter, Ida Sybille, Juckel, Georg, Nieratschker, Vanessa, Dannlowski, Udo, Schaupp, Sabrina K., Schmauß, Max, Zimmermann, Jörg, Reimer, Jens, Schulz, Sybille, Wiltfang, Jens, Reininghaus, Eva, Anghelescu, Ion‐George, Arolt, Volker, Baune, Bernhard T., Konrad, Carsten, Thiel, Andreas, Fallgatter, Andreas J., Figge, Christian, von Hagen, Martin, Koller, Manfred, Lang, Fabian U., Wigand, Moritz E., Becker, Thomas, Jäger, Markus, Dietrich, Detlef E., Stierl, Sebastian, Scherk, Harald, Spitzer, Carsten, Folkerts, Here, Witt, Stephanie H., Degenhardt, Franziska, Forstner, Andreas J., Rietschel, Marcella, Nöthen, Markus M., Falkai, Peter, Schulze, Thomas G., Heilbronner, Urs
author_facet Budde, Monika, Anderson‐Schmidt, Heike, Gade, Katrin, Reich‐Erkelenz, Daniela, Adorjan, Kristina, Kalman, Janos L., Senner, Fanny, Papiol, Sergi, Andlauer, Till F. M., Comes, Ashley L., Schulte, Eva C., Klöhn‐Saghatolislam, Farah, Gryaznova, Anna, Hake, Maria, Bartholdi, Kim, Flatau, Laura, Reitt, Markus, Quast, Silke, Stegmaier, Sophia, Meyers, Milena, Emons, Barbara, Haußleiter, Ida Sybille, Juckel, Georg, Nieratschker, Vanessa, Dannlowski, Udo, Schaupp, Sabrina K., Schmauß, Max, Zimmermann, Jörg, Reimer, Jens, Schulz, Sybille, Wiltfang, Jens, Reininghaus, Eva, Anghelescu, Ion‐George, Arolt, Volker, Baune, Bernhard T., Konrad, Carsten, Thiel, Andreas, Fallgatter, Andreas J., Figge, Christian, von Hagen, Martin, Koller, Manfred, Lang, Fabian U., Wigand, Moritz E., Becker, Thomas, Jäger, Markus, Dietrich, Detlef E., Stierl, Sebastian, Scherk, Harald, Spitzer, Carsten, Folkerts, Here, Witt, Stephanie H., Degenhardt, Franziska, Forstner, Andreas J., Rietschel, Marcella, Nöthen, Markus M., Falkai, Peter, Schulze, Thomas G., Heilbronner, Urs, Budde, Monika, Anderson‐Schmidt, Heike, Gade, Katrin, Reich‐Erkelenz, Daniela, Adorjan, Kristina, Kalman, Janos L., Senner, Fanny, Papiol, Sergi, Andlauer, Till F. M., Comes, Ashley L., Schulte, Eva C., Klöhn‐Saghatolislam, Farah, Gryaznova, Anna, Hake, Maria, Bartholdi, Kim, Flatau, Laura, Reitt, Markus, Quast, Silke, Stegmaier, Sophia, Meyers, Milena, Emons, Barbara, Haußleiter, Ida Sybille, Juckel, Georg, Nieratschker, Vanessa, Dannlowski, Udo, Schaupp, Sabrina K., Schmauß, Max, Zimmermann, Jörg, Reimer, Jens, Schulz, Sybille, Wiltfang, Jens, Reininghaus, Eva, Anghelescu, Ion‐George, Arolt, Volker, Baune, Bernhard T., Konrad, Carsten, Thiel, Andreas, Fallgatter, Andreas J., Figge, Christian, von Hagen, Martin, Koller, Manfred, Lang, Fabian U., Wigand, Moritz E., Becker, Thomas, Jäger, Markus, Dietrich, Detlef E., Stierl, Sebastian, Scherk, Harald, Spitzer, Carsten, Folkerts, Here, Witt, Stephanie H., Degenhardt, Franziska, Forstner, Andreas J., Rietschel, Marcella, Nöthen, Markus M., Falkai, Peter, Schulze, Thomas G., Heilbronner, Urs
author_sort budde, monika
container_issue 2
container_start_page 89
container_title American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
container_volume 180
description <jats:p>In current diagnostic systems, schizophrenia and bipolar disorder are still conceptualized as distinct categorical entities. Recently, both clinical and genomic evidence have challenged this Kraepelinian dichotomy. There are only few longitudinal studies addressing potential overlaps between these conditions. Here, we present design and first results of the PsyCourse study (<jats:italic>N</jats:italic> = 891 individuals at baseline), an ongoing transdiagnostic study of the affective‐to‐psychotic continuum that combines longitudinal deep phenotyping and dimensional assessment of psychopathology with an extensive collection of biomaterial. To provide an initial characterization of the PsyCourse study sample, we compare two broad diagnostic groups defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM‐IV) classification system, that is, predominantly affective (<jats:italic>n</jats:italic> = 367 individuals) versus predominantly psychotic disorders (<jats:italic>n</jats:italic> = 524 individuals). Depressive, manic, and psychotic symptoms as well as global functioning over time were contrasted using linear mixed models. Furthermore, we explored the effects of polygenic risk scores for schizophrenia on diagnostic group membership and addressed their effects on nonparticipation in follow‐up visits. While phenotypic results confirmed expected differences in current psychotic symptoms and global functioning, both manic and depressive symptoms did not vary between both groups after correction for multiple testing. Polygenic risk scores for schizophrenia significantly explained part of the variability of diagnostic group. The PsyCourse study presents a unique resource to research the complex relationships of psychopathology and biology in severe mental disorders not confined to traditional diagnostic boundaries and is open for collaborations.</jats:p>
doi_str_mv 10.1002/ajmg.b.32639
facet_avail Online
finc_class_facet Biologie, Psychologie, Medizin
format ElectronicArticle
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
geogr_code not assigned
geogr_code_person not assigned
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9ham1nLmIuMzI2Mzk
imprint Wiley, 2019
imprint_str_mv Wiley, 2019
institution DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161
issn 1552-4841, 1552-485X
issn_str_mv 1552-4841, 1552-485X
language English
last_indexed 2024-03-01T18:05:05.552Z
match_str budde2019alongitudinalapproachtobiologicalpsychiatricresearchthepsycoursestudy
mega_collection Wiley (CrossRef)
physical 89-102
publishDate 2019
publishDateSort 2019
publisher Wiley
record_format ai
recordtype ai
series American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
source_id 49
spelling Budde, Monika Anderson‐Schmidt, Heike Gade, Katrin Reich‐Erkelenz, Daniela Adorjan, Kristina Kalman, Janos L. Senner, Fanny Papiol, Sergi Andlauer, Till F. M. Comes, Ashley L. Schulte, Eva C. Klöhn‐Saghatolislam, Farah Gryaznova, Anna Hake, Maria Bartholdi, Kim Flatau, Laura Reitt, Markus Quast, Silke Stegmaier, Sophia Meyers, Milena Emons, Barbara Haußleiter, Ida Sybille Juckel, Georg Nieratschker, Vanessa Dannlowski, Udo Schaupp, Sabrina K. Schmauß, Max Zimmermann, Jörg Reimer, Jens Schulz, Sybille Wiltfang, Jens Reininghaus, Eva Anghelescu, Ion‐George Arolt, Volker Baune, Bernhard T. Konrad, Carsten Thiel, Andreas Fallgatter, Andreas J. Figge, Christian von Hagen, Martin Koller, Manfred Lang, Fabian U. Wigand, Moritz E. Becker, Thomas Jäger, Markus Dietrich, Detlef E. Stierl, Sebastian Scherk, Harald Spitzer, Carsten Folkerts, Here Witt, Stephanie H. Degenhardt, Franziska Forstner, Andreas J. Rietschel, Marcella Nöthen, Markus M. Falkai, Peter Schulze, Thomas G. Heilbronner, Urs 1552-4841 1552-485X Wiley Cellular and Molecular Neuroscience Psychiatry and Mental health Genetics (clinical) http://dx.doi.org/10.1002/ajmg.b.32639 <jats:p>In current diagnostic systems, schizophrenia and bipolar disorder are still conceptualized as distinct categorical entities. Recently, both clinical and genomic evidence have challenged this Kraepelinian dichotomy. There are only few longitudinal studies addressing potential overlaps between these conditions. Here, we present design and first results of the PsyCourse study (<jats:italic>N</jats:italic> = 891 individuals at baseline), an ongoing transdiagnostic study of the affective‐to‐psychotic continuum that combines longitudinal deep phenotyping and dimensional assessment of psychopathology with an extensive collection of biomaterial. To provide an initial characterization of the PsyCourse study sample, we compare two broad diagnostic groups defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM‐IV) classification system, that is, predominantly affective (<jats:italic>n</jats:italic> = 367 individuals) versus predominantly psychotic disorders (<jats:italic>n</jats:italic> = 524 individuals). Depressive, manic, and psychotic symptoms as well as global functioning over time were contrasted using linear mixed models. Furthermore, we explored the effects of polygenic risk scores for schizophrenia on diagnostic group membership and addressed their effects on nonparticipation in follow‐up visits. While phenotypic results confirmed expected differences in current psychotic symptoms and global functioning, both manic and depressive symptoms did not vary between both groups after correction for multiple testing. Polygenic risk scores for schizophrenia significantly explained part of the variability of diagnostic group. The PsyCourse study presents a unique resource to research the complex relationships of psychopathology and biology in severe mental disorders not confined to traditional diagnostic boundaries and is open for collaborations.</jats:p> A longitudinal approach to biological psychiatric research: The PsyCourse study American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
spellingShingle Budde, Monika, Anderson‐Schmidt, Heike, Gade, Katrin, Reich‐Erkelenz, Daniela, Adorjan, Kristina, Kalman, Janos L., Senner, Fanny, Papiol, Sergi, Andlauer, Till F. M., Comes, Ashley L., Schulte, Eva C., Klöhn‐Saghatolislam, Farah, Gryaznova, Anna, Hake, Maria, Bartholdi, Kim, Flatau, Laura, Reitt, Markus, Quast, Silke, Stegmaier, Sophia, Meyers, Milena, Emons, Barbara, Haußleiter, Ida Sybille, Juckel, Georg, Nieratschker, Vanessa, Dannlowski, Udo, Schaupp, Sabrina K., Schmauß, Max, Zimmermann, Jörg, Reimer, Jens, Schulz, Sybille, Wiltfang, Jens, Reininghaus, Eva, Anghelescu, Ion‐George, Arolt, Volker, Baune, Bernhard T., Konrad, Carsten, Thiel, Andreas, Fallgatter, Andreas J., Figge, Christian, von Hagen, Martin, Koller, Manfred, Lang, Fabian U., Wigand, Moritz E., Becker, Thomas, Jäger, Markus, Dietrich, Detlef E., Stierl, Sebastian, Scherk, Harald, Spitzer, Carsten, Folkerts, Here, Witt, Stephanie H., Degenhardt, Franziska, Forstner, Andreas J., Rietschel, Marcella, Nöthen, Markus M., Falkai, Peter, Schulze, Thomas G., Heilbronner, Urs, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, A longitudinal approach to biological psychiatric research: The PsyCourse study, Cellular and Molecular Neuroscience, Psychiatry and Mental health, Genetics (clinical)
title A longitudinal approach to biological psychiatric research: The PsyCourse study
title_full A longitudinal approach to biological psychiatric research: The PsyCourse study
title_fullStr A longitudinal approach to biological psychiatric research: The PsyCourse study
title_full_unstemmed A longitudinal approach to biological psychiatric research: The PsyCourse study
title_short A longitudinal approach to biological psychiatric research: The PsyCourse study
title_sort a longitudinal approach to biological psychiatric research: the psycourse study
title_unstemmed A longitudinal approach to biological psychiatric research: The PsyCourse study
topic Cellular and Molecular Neuroscience, Psychiatry and Mental health, Genetics (clinical)
url http://dx.doi.org/10.1002/ajmg.b.32639