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Enantioselective Palladium‐Catalyzed Insertion of α‐Aryl‐α‐diazoacetates into the OH Bonds of Phenols
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Zeitschriftentitel: | Angewandte Chemie International Edition |
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Personen und Körperschaften: | , , , , |
In: | Angewandte Chemie International Edition, 53, 2014, 11, S. 2978-2981 |
Medientyp: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Wiley
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Schlagwörter: |
Zusammenfassung: | <jats:title>Abstract</jats:title><jats:p>A palladium‐catalyzed asymmetric OH insertion reaction was developed. Palladium complexes with chiral spiro bisoxazoline ligands promoted the insertion of α‐aryl‐α‐diazoacetates into the OH bond of phenols with high yield and excellent enantioselectivity under mild reaction conditions. This palladium‐catalyzed asymmetric OH insertion reaction provided an efficient and highly enantioselective method for the preparation of synthetically useful optically active α‐aryl‐α‐aryloxyacetates.</jats:p> |
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Umfang: | 2978-2981 |
ISSN: |
1433-7851
1521-3773 |
DOI: | 10.1002/anie.201309820 |