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Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs

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Zeitschriftentitel: Journal of Biochemical and Molecular Toxicology
Personen und Körperschaften: Zhao, Yuhang, Su, Xin, Gao, Yanrong, Yin, Haijing, Wang, Li, Qiao, Rui, Wang, Suhua
In: Journal of Biochemical and Molecular Toxicology, 33, 2019, 7
Medientyp: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
author_facet Zhao, Yuhang
Su, Xin
Gao, Yanrong
Yin, Haijing
Wang, Li
Qiao, Rui
Wang, Suhua
Zhao, Yuhang
Su, Xin
Gao, Yanrong
Yin, Haijing
Wang, Li
Qiao, Rui
Wang, Suhua
author Zhao, Yuhang
Su, Xin
Gao, Yanrong
Yin, Haijing
Wang, Li
Qiao, Rui
Wang, Suhua
spellingShingle Zhao, Yuhang
Su, Xin
Gao, Yanrong
Yin, Haijing
Wang, Li
Qiao, Rui
Wang, Suhua
Journal of Biochemical and Molecular Toxicology
Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
Health, Toxicology and Mutagenesis
Toxicology
Molecular Biology
Molecular Medicine
Biochemistry
General Medicine
author_sort zhao, yuhang
spelling Zhao, Yuhang Su, Xin Gao, Yanrong Yin, Haijing Wang, Li Qiao, Rui Wang, Suhua 1095-6670 1099-0461 Wiley Health, Toxicology and Mutagenesis Toxicology Molecular Biology Molecular Medicine Biochemistry General Medicine http://dx.doi.org/10.1002/jbt.22334 <jats:title>Abstract</jats:title><jats:p>Chronic arsenic exposure through water intake is a worldwide issue, which has caused many diseases. Lungs are the first target organ of arsenic and lung inflammation, autophagy, and even the onset of tumors can be induced by arsenic exposure. Here, we tested the outcome of low‐concentration arsenic exposure in rat lungs. Tissue changes, inflammation, autophagy, and other physiological responses were observed in this study. Results showed that low‐concentration exposure of arsenite through water intake could initiate autophagy and inflammation in lungs but high concentration exposure produced a weak autophagy response and accentuated inflammation with the possibility of a chronic inflammation environment emerging followed by tumorigenesis.</jats:p> Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs Journal of Biochemical and Molecular Toxicology
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title Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
title_unstemmed Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
title_full Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
title_fullStr Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
title_full_unstemmed Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
title_short Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
title_sort exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
topic Health, Toxicology and Mutagenesis
Toxicology
Molecular Biology
Molecular Medicine
Biochemistry
General Medicine
url http://dx.doi.org/10.1002/jbt.22334
publishDate 2019
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description <jats:title>Abstract</jats:title><jats:p>Chronic arsenic exposure through water intake is a worldwide issue, which has caused many diseases. Lungs are the first target organ of arsenic and lung inflammation, autophagy, and even the onset of tumors can be induced by arsenic exposure. Here, we tested the outcome of low‐concentration arsenic exposure in rat lungs. Tissue changes, inflammation, autophagy, and other physiological responses were observed in this study. Results showed that low‐concentration exposure of arsenite through water intake could initiate autophagy and inflammation in lungs but high concentration exposure produced a weak autophagy response and accentuated inflammation with the possibility of a chronic inflammation environment emerging followed by tumorigenesis.</jats:p>
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author Zhao, Yuhang, Su, Xin, Gao, Yanrong, Yin, Haijing, Wang, Li, Qiao, Rui, Wang, Suhua
author_facet Zhao, Yuhang, Su, Xin, Gao, Yanrong, Yin, Haijing, Wang, Li, Qiao, Rui, Wang, Suhua, Zhao, Yuhang, Su, Xin, Gao, Yanrong, Yin, Haijing, Wang, Li, Qiao, Rui, Wang, Suhua
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description <jats:title>Abstract</jats:title><jats:p>Chronic arsenic exposure through water intake is a worldwide issue, which has caused many diseases. Lungs are the first target organ of arsenic and lung inflammation, autophagy, and even the onset of tumors can be induced by arsenic exposure. Here, we tested the outcome of low‐concentration arsenic exposure in rat lungs. Tissue changes, inflammation, autophagy, and other physiological responses were observed in this study. Results showed that low‐concentration exposure of arsenite through water intake could initiate autophagy and inflammation in lungs but high concentration exposure produced a weak autophagy response and accentuated inflammation with the possibility of a chronic inflammation environment emerging followed by tumorigenesis.</jats:p>
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spelling Zhao, Yuhang Su, Xin Gao, Yanrong Yin, Haijing Wang, Li Qiao, Rui Wang, Suhua 1095-6670 1099-0461 Wiley Health, Toxicology and Mutagenesis Toxicology Molecular Biology Molecular Medicine Biochemistry General Medicine http://dx.doi.org/10.1002/jbt.22334 <jats:title>Abstract</jats:title><jats:p>Chronic arsenic exposure through water intake is a worldwide issue, which has caused many diseases. Lungs are the first target organ of arsenic and lung inflammation, autophagy, and even the onset of tumors can be induced by arsenic exposure. Here, we tested the outcome of low‐concentration arsenic exposure in rat lungs. Tissue changes, inflammation, autophagy, and other physiological responses were observed in this study. Results showed that low‐concentration exposure of arsenite through water intake could initiate autophagy and inflammation in lungs but high concentration exposure produced a weak autophagy response and accentuated inflammation with the possibility of a chronic inflammation environment emerging followed by tumorigenesis.</jats:p> Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs Journal of Biochemical and Molecular Toxicology
spellingShingle Zhao, Yuhang, Su, Xin, Gao, Yanrong, Yin, Haijing, Wang, Li, Qiao, Rui, Wang, Suhua, Journal of Biochemical and Molecular Toxicology, Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs, Health, Toxicology and Mutagenesis, Toxicology, Molecular Biology, Molecular Medicine, Biochemistry, General Medicine
title Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
title_full Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
title_fullStr Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
title_full_unstemmed Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
title_short Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
title_sort exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
title_unstemmed Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs
topic Health, Toxicology and Mutagenesis, Toxicology, Molecular Biology, Molecular Medicine, Biochemistry, General Medicine
url http://dx.doi.org/10.1002/jbt.22334