%0 Electronic Article %A Zhao, Yuhang and Su, Xin and Gao, Yanrong and Yin, Haijing and Wang, Li and Qiao, Rui and Wang, Suhua %I Wiley %D 2019 %D 2019 %G English %@ 1095-6670 %@ 1099-0461 %~ Katalog UB TU-Chemnitz %T Exposure of low‐concentration arsenic‐initiated inflammation and autophagy in rat lungs %V 33 %J Journal of Biochemical and Molecular Toxicology %V 33 %N 7 %U http://dx.doi.org/10.1002/jbt.22334 %X AbstractChronic arsenic exposure through water intake is a worldwide issue, which has caused many diseases. Lungs are the first target organ of arsenic and lung inflammation, autophagy, and even the onset of tumors can be induced by arsenic exposure. Here, we tested the outcome of low‐concentration arsenic exposure in rat lungs. Tissue changes, inflammation, autophagy, and other physiological responses were observed in this study. Results showed that low‐concentration exposure of arsenite through water intake could initiate autophagy and inflammation in lungs but high concentration exposure produced a weak autophagy response and accentuated inflammation with the possibility of a chronic inflammation environment emerging followed by tumorigenesis. %Z https://katalog.bibliothek.tu-chemnitz.de/Record/ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9qYnQuMjIzMzQ %U https://katalog.bibliothek.tu-chemnitz.de/Record/ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9qYnQuMjIzMzQ