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Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer
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| Zeitschriftentitel: | JGH Open |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , |
| In: | JGH Open, 4, 2020, 2, S. 160-165 |
| Medientyp: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Fukuda, Hiromu Ishihara, Ryu Shimamoto, Yusaku Kono, Mitsuhiro Nakagawa, Kentaro Ohmori, Masayasu Matsuno, Kenshi Iwagami, Hiroyoshi Inoue, Shuntaro Iwatsubo, Taro Nakahira, Hiroko Matsuura, Noriko Shichijo, Satoki Maekawa, Akira Kanesaka, Takashi Takeuchi, Yoji Higashino, Koji Uedo, Noriya Kitamura, Masanori Nakatsuka, Shinichi Fukuda, Hiromu Ishihara, Ryu Shimamoto, Yusaku Kono, Mitsuhiro Nakagawa, Kentaro Ohmori, Masayasu Matsuno, Kenshi Iwagami, Hiroyoshi Inoue, Shuntaro Iwatsubo, Taro Nakahira, Hiroko Matsuura, Noriko Shichijo, Satoki Maekawa, Akira Kanesaka, Takashi Takeuchi, Yoji Higashino, Koji Uedo, Noriya Kitamura, Masanori Nakatsuka, Shinichi |
|---|---|
| author |
Fukuda, Hiromu Ishihara, Ryu Shimamoto, Yusaku Kono, Mitsuhiro Nakagawa, Kentaro Ohmori, Masayasu Matsuno, Kenshi Iwagami, Hiroyoshi Inoue, Shuntaro Iwatsubo, Taro Nakahira, Hiroko Matsuura, Noriko Shichijo, Satoki Maekawa, Akira Kanesaka, Takashi Takeuchi, Yoji Higashino, Koji Uedo, Noriya Kitamura, Masanori Nakatsuka, Shinichi |
| spellingShingle |
Fukuda, Hiromu Ishihara, Ryu Shimamoto, Yusaku Kono, Mitsuhiro Nakagawa, Kentaro Ohmori, Masayasu Matsuno, Kenshi Iwagami, Hiroyoshi Inoue, Shuntaro Iwatsubo, Taro Nakahira, Hiroko Matsuura, Noriko Shichijo, Satoki Maekawa, Akira Kanesaka, Takashi Takeuchi, Yoji Higashino, Koji Uedo, Noriya Kitamura, Masanori Nakatsuka, Shinichi JGH Open Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer Gastroenterology Hepatology |
| author_sort |
fukuda, hiromu |
| spelling |
Fukuda, Hiromu Ishihara, Ryu Shimamoto, Yusaku Kono, Mitsuhiro Nakagawa, Kentaro Ohmori, Masayasu Matsuno, Kenshi Iwagami, Hiroyoshi Inoue, Shuntaro Iwatsubo, Taro Nakahira, Hiroko Matsuura, Noriko Shichijo, Satoki Maekawa, Akira Kanesaka, Takashi Takeuchi, Yoji Higashino, Koji Uedo, Noriya Kitamura, Masanori Nakatsuka, Shinichi 2397-9070 2397-9070 Wiley Gastroenterology Hepatology http://dx.doi.org/10.1002/jgh3.12233 <jats:sec><jats:title>Background and Aim</jats:title><jats:p>Endoscopic submucosal dissection (ESD) sometimes results in <jats:italic>en</jats:italic> bloc resection with a positive or inconclusive horizontal margin (HM1 or HMX, respectively) on histological evaluation. The specific risk for such situations is unclear. We therefore investigated the outcome of ESD with HM1 or HMX.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This single‐center retrospective study was performed at Osaka International Cancer Institute. A total of 886 esophageal squamous cell carcinoma lesions in 749 patients treated from April 2005 to June 2015 were evaluated according to the following inclusion criteria: <jats:italic>en</jats:italic> bloc resection with no residual lesion, HM1 or HMX status, no prior treatment, and no additional treatment. We classified HM1 and HMX into type A, in which cancer was exposed on the HM, and type B, in which the HM status was unclear because of mechanical or thermal damage. We further classified type B according to the distance between the cancer and the edge of the specimen: type B1, <1 mm and type B2, ≥1 mm.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The resection margin was judged as HM1 or HMX in 5.0% (39/767; 95% confidence interval, 3.5–6.6%) of the <jats:italic>en</jats:italic> bloc resected specimens. Of 39 lesions, 30 fulfilled the inclusion criteria. Local recurrence developed in 8 of 30 lesions (26.7%). The local recurrence rates for types A, B1, and B2 were 40% (6/15 lesions), 28.5% (2/7 lesions), and 0.0% (0/8 lesions), respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Although a statistical analysis was not conducted because of the limited events, the pathological HM status may be a useful predictor of local recurrence.</jats:p></jats:sec> Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer JGH Open |
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| title |
Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| title_unstemmed |
Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| title_full |
Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| title_fullStr |
Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| title_full_unstemmed |
Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| title_short |
Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| title_sort |
effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| topic |
Gastroenterology Hepatology |
| url |
http://dx.doi.org/10.1002/jgh3.12233 |
| publishDate |
2020 |
| physical |
160-165 |
| description |
<jats:sec><jats:title>Background and Aim</jats:title><jats:p>Endoscopic submucosal dissection (ESD) sometimes results in <jats:italic>en</jats:italic> bloc resection with a positive or inconclusive horizontal margin (HM1 or HMX, respectively) on histological evaluation. The specific risk for such situations is unclear. We therefore investigated the outcome of ESD with HM1 or HMX.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This single‐center retrospective study was performed at Osaka International Cancer Institute. A total of 886 esophageal squamous cell carcinoma lesions in 749 patients treated from April 2005 to June 2015 were evaluated according to the following inclusion criteria: <jats:italic>en</jats:italic> bloc resection with no residual lesion, HM1 or HMX status, no prior treatment, and no additional treatment. We classified HM1 and HMX into type A, in which cancer was exposed on the HM, and type B, in which the HM status was unclear because of mechanical or thermal damage. We further classified type B according to the distance between the cancer and the edge of the specimen: type B1, <1 mm and type B2, ≥1 mm.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The resection margin was judged as HM1 or HMX in 5.0% (39/767; 95% confidence interval, 3.5–6.6%) of the <jats:italic>en</jats:italic> bloc resected specimens. Of 39 lesions, 30 fulfilled the inclusion criteria. Local recurrence developed in 8 of 30 lesions (26.7%). The local recurrence rates for types A, B1, and B2 were 40% (6/15 lesions), 28.5% (2/7 lesions), and 0.0% (0/8 lesions), respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Although a statistical analysis was not conducted because of the limited events, the pathological HM status may be a useful predictor of local recurrence.</jats:p></jats:sec> |
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| author | Fukuda, Hiromu, Ishihara, Ryu, Shimamoto, Yusaku, Kono, Mitsuhiro, Nakagawa, Kentaro, Ohmori, Masayasu, Matsuno, Kenshi, Iwagami, Hiroyoshi, Inoue, Shuntaro, Iwatsubo, Taro, Nakahira, Hiroko, Matsuura, Noriko, Shichijo, Satoki, Maekawa, Akira, Kanesaka, Takashi, Takeuchi, Yoji, Higashino, Koji, Uedo, Noriya, Kitamura, Masanori, Nakatsuka, Shinichi |
| author_facet | Fukuda, Hiromu, Ishihara, Ryu, Shimamoto, Yusaku, Kono, Mitsuhiro, Nakagawa, Kentaro, Ohmori, Masayasu, Matsuno, Kenshi, Iwagami, Hiroyoshi, Inoue, Shuntaro, Iwatsubo, Taro, Nakahira, Hiroko, Matsuura, Noriko, Shichijo, Satoki, Maekawa, Akira, Kanesaka, Takashi, Takeuchi, Yoji, Higashino, Koji, Uedo, Noriya, Kitamura, Masanori, Nakatsuka, Shinichi, Fukuda, Hiromu, Ishihara, Ryu, Shimamoto, Yusaku, Kono, Mitsuhiro, Nakagawa, Kentaro, Ohmori, Masayasu, Matsuno, Kenshi, Iwagami, Hiroyoshi, Inoue, Shuntaro, Iwatsubo, Taro, Nakahira, Hiroko, Matsuura, Noriko, Shichijo, Satoki, Maekawa, Akira, Kanesaka, Takashi, Takeuchi, Yoji, Higashino, Koji, Uedo, Noriya, Kitamura, Masanori, Nakatsuka, Shinichi |
| author_sort | fukuda, hiromu |
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| description | <jats:sec><jats:title>Background and Aim</jats:title><jats:p>Endoscopic submucosal dissection (ESD) sometimes results in <jats:italic>en</jats:italic> bloc resection with a positive or inconclusive horizontal margin (HM1 or HMX, respectively) on histological evaluation. The specific risk for such situations is unclear. We therefore investigated the outcome of ESD with HM1 or HMX.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This single‐center retrospective study was performed at Osaka International Cancer Institute. A total of 886 esophageal squamous cell carcinoma lesions in 749 patients treated from April 2005 to June 2015 were evaluated according to the following inclusion criteria: <jats:italic>en</jats:italic> bloc resection with no residual lesion, HM1 or HMX status, no prior treatment, and no additional treatment. We classified HM1 and HMX into type A, in which cancer was exposed on the HM, and type B, in which the HM status was unclear because of mechanical or thermal damage. We further classified type B according to the distance between the cancer and the edge of the specimen: type B1, <1 mm and type B2, ≥1 mm.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The resection margin was judged as HM1 or HMX in 5.0% (39/767; 95% confidence interval, 3.5–6.6%) of the <jats:italic>en</jats:italic> bloc resected specimens. Of 39 lesions, 30 fulfilled the inclusion criteria. Local recurrence developed in 8 of 30 lesions (26.7%). The local recurrence rates for types A, B1, and B2 were 40% (6/15 lesions), 28.5% (2/7 lesions), and 0.0% (0/8 lesions), respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Although a statistical analysis was not conducted because of the limited events, the pathological HM status may be a useful predictor of local recurrence.</jats:p></jats:sec> |
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| imprint | Wiley, 2020 |
| imprint_str_mv | Wiley, 2020 |
| institution | DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
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| spelling | Fukuda, Hiromu Ishihara, Ryu Shimamoto, Yusaku Kono, Mitsuhiro Nakagawa, Kentaro Ohmori, Masayasu Matsuno, Kenshi Iwagami, Hiroyoshi Inoue, Shuntaro Iwatsubo, Taro Nakahira, Hiroko Matsuura, Noriko Shichijo, Satoki Maekawa, Akira Kanesaka, Takashi Takeuchi, Yoji Higashino, Koji Uedo, Noriya Kitamura, Masanori Nakatsuka, Shinichi 2397-9070 2397-9070 Wiley Gastroenterology Hepatology http://dx.doi.org/10.1002/jgh3.12233 <jats:sec><jats:title>Background and Aim</jats:title><jats:p>Endoscopic submucosal dissection (ESD) sometimes results in <jats:italic>en</jats:italic> bloc resection with a positive or inconclusive horizontal margin (HM1 or HMX, respectively) on histological evaluation. The specific risk for such situations is unclear. We therefore investigated the outcome of ESD with HM1 or HMX.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This single‐center retrospective study was performed at Osaka International Cancer Institute. A total of 886 esophageal squamous cell carcinoma lesions in 749 patients treated from April 2005 to June 2015 were evaluated according to the following inclusion criteria: <jats:italic>en</jats:italic> bloc resection with no residual lesion, HM1 or HMX status, no prior treatment, and no additional treatment. We classified HM1 and HMX into type A, in which cancer was exposed on the HM, and type B, in which the HM status was unclear because of mechanical or thermal damage. We further classified type B according to the distance between the cancer and the edge of the specimen: type B1, <1 mm and type B2, ≥1 mm.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The resection margin was judged as HM1 or HMX in 5.0% (39/767; 95% confidence interval, 3.5–6.6%) of the <jats:italic>en</jats:italic> bloc resected specimens. Of 39 lesions, 30 fulfilled the inclusion criteria. Local recurrence developed in 8 of 30 lesions (26.7%). The local recurrence rates for types A, B1, and B2 were 40% (6/15 lesions), 28.5% (2/7 lesions), and 0.0% (0/8 lesions), respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Although a statistical analysis was not conducted because of the limited events, the pathological HM status may be a useful predictor of local recurrence.</jats:p></jats:sec> Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer JGH Open |
| spellingShingle | Fukuda, Hiromu, Ishihara, Ryu, Shimamoto, Yusaku, Kono, Mitsuhiro, Nakagawa, Kentaro, Ohmori, Masayasu, Matsuno, Kenshi, Iwagami, Hiroyoshi, Inoue, Shuntaro, Iwatsubo, Taro, Nakahira, Hiroko, Matsuura, Noriko, Shichijo, Satoki, Maekawa, Akira, Kanesaka, Takashi, Takeuchi, Yoji, Higashino, Koji, Uedo, Noriya, Kitamura, Masanori, Nakatsuka, Shinichi, JGH Open, Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer, Gastroenterology, Hepatology |
| title | Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| title_full | Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| title_fullStr | Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| title_full_unstemmed | Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| title_short | Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| title_sort | effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| title_unstemmed | Effect of horizontal margin status and risk of local recurrence after endoscopic submucosal dissection for superficial esophageal cancer |
| topic | Gastroenterology, Hepatology |
| url | http://dx.doi.org/10.1002/jgh3.12233 |