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mTOR: A double-edged sword for diabetes
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| Zeitschriftentitel: | Journal of Leukocyte Biology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Leukocyte Biology, 106, 2019, 2, S. 385-395 |
| Medientyp: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
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Tuo, Yali Xiang, Ming Tuo, Yali Xiang, Ming |
|---|---|
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Tuo, Yali Xiang, Ming |
| spellingShingle |
Tuo, Yali Xiang, Ming Journal of Leukocyte Biology mTOR: A double-edged sword for diabetes Cell Biology Immunology Immunology and Allergy |
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tuo, yali |
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Tuo, Yali Xiang, Ming 1938-3673 0741-5400 Oxford University Press (OUP) Cell Biology Immunology Immunology and Allergy http://dx.doi.org/10.1002/jlb.3mr0317-095rr <jats:title>Abstract</jats:title> <jats:p>Diabetes is both a metabolic and an immune disorder. One intriguing link between the two is the serine-threonine protein kinase mammalian target of rapamycin (mTOR). As a component of the PI3K/Akt pathway and other cellular signals, mTOR is a key regulator of fuel metabolism and function of both pancreatic islet β cells and immune cells. Consequently, it seems that mTOR has both anti- and prodiabetic effects. On the one hand, activation of mTOR in β cells can increase their growth and proliferation, opposing impairments of insulin secretion in diabetes. On the other, activation of mTOR signaling in specific immune cells alters their fuel metabolism, amplifying their contributions to β-cell dysfunction, contributing to the development of diabetes. In this review, we focus on roles of mTOR signaling in pancreatic β cells and immune cells and their implications in the pathogenesis and treatment of diabetes.</jats:p> mTOR: A double-edged sword for diabetes Journal of Leukocyte Biology |
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mTOR: A double-edged sword for diabetes |
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mTOR: A double-edged sword for diabetes |
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mTOR: A double-edged sword for diabetes |
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mTOR: A double-edged sword for diabetes |
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mTOR: A double-edged sword for diabetes |
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mTOR: A double-edged sword for diabetes |
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mtor: a double-edged sword for diabetes |
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Cell Biology Immunology Immunology and Allergy |
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http://dx.doi.org/10.1002/jlb.3mr0317-095rr |
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2019 |
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385-395 |
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<jats:title>Abstract</jats:title>
<jats:p>Diabetes is both a metabolic and an immune disorder. One intriguing link between the two is the serine-threonine protein kinase mammalian target of rapamycin (mTOR). As a component of the PI3K/Akt pathway and other cellular signals, mTOR is a key regulator of fuel metabolism and function of both pancreatic islet β cells and immune cells. Consequently, it seems that mTOR has both anti- and prodiabetic effects. On the one hand, activation of mTOR in β cells can increase their growth and proliferation, opposing impairments of insulin secretion in diabetes. On the other, activation of mTOR signaling in specific immune cells alters their fuel metabolism, amplifying their contributions to β-cell dysfunction, contributing to the development of diabetes. In this review, we focus on roles of mTOR signaling in pancreatic β cells and immune cells and their implications in the pathogenesis and treatment of diabetes.</jats:p> |
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| description | <jats:title>Abstract</jats:title> <jats:p>Diabetes is both a metabolic and an immune disorder. One intriguing link between the two is the serine-threonine protein kinase mammalian target of rapamycin (mTOR). As a component of the PI3K/Akt pathway and other cellular signals, mTOR is a key regulator of fuel metabolism and function of both pancreatic islet β cells and immune cells. Consequently, it seems that mTOR has both anti- and prodiabetic effects. On the one hand, activation of mTOR in β cells can increase their growth and proliferation, opposing impairments of insulin secretion in diabetes. On the other, activation of mTOR signaling in specific immune cells alters their fuel metabolism, amplifying their contributions to β-cell dysfunction, contributing to the development of diabetes. In this review, we focus on roles of mTOR signaling in pancreatic β cells and immune cells and their implications in the pathogenesis and treatment of diabetes.</jats:p> |
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| spelling | Tuo, Yali Xiang, Ming 1938-3673 0741-5400 Oxford University Press (OUP) Cell Biology Immunology Immunology and Allergy http://dx.doi.org/10.1002/jlb.3mr0317-095rr <jats:title>Abstract</jats:title> <jats:p>Diabetes is both a metabolic and an immune disorder. One intriguing link between the two is the serine-threonine protein kinase mammalian target of rapamycin (mTOR). As a component of the PI3K/Akt pathway and other cellular signals, mTOR is a key regulator of fuel metabolism and function of both pancreatic islet β cells and immune cells. Consequently, it seems that mTOR has both anti- and prodiabetic effects. On the one hand, activation of mTOR in β cells can increase their growth and proliferation, opposing impairments of insulin secretion in diabetes. On the other, activation of mTOR signaling in specific immune cells alters their fuel metabolism, amplifying their contributions to β-cell dysfunction, contributing to the development of diabetes. In this review, we focus on roles of mTOR signaling in pancreatic β cells and immune cells and their implications in the pathogenesis and treatment of diabetes.</jats:p> mTOR: A double-edged sword for diabetes Journal of Leukocyte Biology |
| spellingShingle | Tuo, Yali, Xiang, Ming, Journal of Leukocyte Biology, mTOR: A double-edged sword for diabetes, Cell Biology, Immunology, Immunology and Allergy |
| title | mTOR: A double-edged sword for diabetes |
| title_full | mTOR: A double-edged sword for diabetes |
| title_fullStr | mTOR: A double-edged sword for diabetes |
| title_full_unstemmed | mTOR: A double-edged sword for diabetes |
| title_short | mTOR: A double-edged sword for diabetes |
| title_sort | mtor: a double-edged sword for diabetes |
| title_unstemmed | mTOR: A double-edged sword for diabetes |
| topic | Cell Biology, Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1002/jlb.3mr0317-095rr |