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Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke
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| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | FEBS Letters, 512, 2002, 1-3, S. 218-222 |
| Medientyp: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Yamaguchi, Yu Kagota, Satomi Haginaka, Jun Kunitomo, Masaru Yamaguchi, Yu Kagota, Satomi Haginaka, Jun Kunitomo, Masaru |
|---|---|
| author |
Yamaguchi, Yu Kagota, Satomi Haginaka, Jun Kunitomo, Masaru |
| spellingShingle |
Yamaguchi, Yu Kagota, Satomi Haginaka, Jun Kunitomo, Masaru FEBS Letters Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| author_sort |
yamaguchi, yu |
| spelling |
Yamaguchi, Yu Kagota, Satomi Haginaka, Jun Kunitomo, Masaru 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/s0014-5793(02)02263-9 <jats:p>Aqueous extracts of cigarette smoke (CSE) can oxidatively modify plasma low‐density lipoprotein (LDL). The aim of the present study was to elucidate the participation of peroxynitrite in LDL oxidation. When LDL was incubated with CSE, its oxidative modification was dependent on time and concentration. It could be effectively prevented by vitamin E, partially by superoxide dismutase, but hardly by catalase, mannitol and metal chelators. CSE also increased the 3‐nitrotyrosine content in LDL. A similar increase of 3‐nitrotyrosine occurred after incubation of LDL with a peroxynitrite generating agent, 3‐morpholinosydnonimine, thus suggesting that prominent pro‐oxidants in CSE are peroxynitrite‐generating species.</jats:p> Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke FEBS Letters |
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Wiley, 2002 |
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Wiley, 2002 |
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| title |
Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke |
| title_unstemmed |
Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke |
| title_full |
Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke |
| title_fullStr |
Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke |
| title_full_unstemmed |
Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke |
| title_short |
Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke |
| title_sort |
participation of peroxynitrite in oxidative modification of ldl by aqueous extracts of cigarette smoke |
| topic |
Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
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http://dx.doi.org/10.1016/s0014-5793(02)02263-9 |
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2002 |
| physical |
218-222 |
| description |
<jats:p>Aqueous extracts of cigarette smoke (CSE) can oxidatively modify plasma low‐density lipoprotein (LDL). The aim of the present study was to elucidate the participation of peroxynitrite in LDL oxidation. When LDL was incubated with CSE, its oxidative modification was dependent on time and concentration. It could be effectively prevented by vitamin E, partially by superoxide dismutase, but hardly by catalase, mannitol and metal chelators. CSE also increased the 3‐nitrotyrosine content in LDL. A similar increase of 3‐nitrotyrosine occurred after incubation of LDL with a peroxynitrite generating agent, 3‐morpholinosydnonimine, thus suggesting that prominent pro‐oxidants in CSE are peroxynitrite‐generating species.</jats:p> |
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| author | Yamaguchi, Yu, Kagota, Satomi, Haginaka, Jun, Kunitomo, Masaru |
| author_facet | Yamaguchi, Yu, Kagota, Satomi, Haginaka, Jun, Kunitomo, Masaru, Yamaguchi, Yu, Kagota, Satomi, Haginaka, Jun, Kunitomo, Masaru |
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| description | <jats:p>Aqueous extracts of cigarette smoke (CSE) can oxidatively modify plasma low‐density lipoprotein (LDL). The aim of the present study was to elucidate the participation of peroxynitrite in LDL oxidation. When LDL was incubated with CSE, its oxidative modification was dependent on time and concentration. It could be effectively prevented by vitamin E, partially by superoxide dismutase, but hardly by catalase, mannitol and metal chelators. CSE also increased the 3‐nitrotyrosine content in LDL. A similar increase of 3‐nitrotyrosine occurred after incubation of LDL with a peroxynitrite generating agent, 3‐morpholinosydnonimine, thus suggesting that prominent pro‐oxidants in CSE are peroxynitrite‐generating species.</jats:p> |
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| imprint | Wiley, 2002 |
| imprint_str_mv | Wiley, 2002 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 218-222 |
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| series | FEBS Letters |
| source_id | 49 |
| spelling | Yamaguchi, Yu Kagota, Satomi Haginaka, Jun Kunitomo, Masaru 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/s0014-5793(02)02263-9 <jats:p>Aqueous extracts of cigarette smoke (CSE) can oxidatively modify plasma low‐density lipoprotein (LDL). The aim of the present study was to elucidate the participation of peroxynitrite in LDL oxidation. When LDL was incubated with CSE, its oxidative modification was dependent on time and concentration. It could be effectively prevented by vitamin E, partially by superoxide dismutase, but hardly by catalase, mannitol and metal chelators. CSE also increased the 3‐nitrotyrosine content in LDL. A similar increase of 3‐nitrotyrosine occurred after incubation of LDL with a peroxynitrite generating agent, 3‐morpholinosydnonimine, thus suggesting that prominent pro‐oxidants in CSE are peroxynitrite‐generating species.</jats:p> Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke FEBS Letters |
| spellingShingle | Yamaguchi, Yu, Kagota, Satomi, Haginaka, Jun, Kunitomo, Masaru, FEBS Letters, Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke, Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| title | Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke |
| title_full | Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke |
| title_fullStr | Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke |
| title_full_unstemmed | Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke |
| title_short | Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke |
| title_sort | participation of peroxynitrite in oxidative modification of ldl by aqueous extracts of cigarette smoke |
| title_unstemmed | Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke |
| topic | Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| url | http://dx.doi.org/10.1016/s0014-5793(02)02263-9 |