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Buchumschlag von Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

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Bibliographische Detailangaben
Zeitschriftentitel: Nature Communications
Personen und Körperschaften: Zillikens, M. Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M., Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, Jian’an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A. M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong-Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O’Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephen C. J., Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Räikkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Tan, Sian-Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichmann, H.-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J. F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, Kiel, Douglas P.
In: Nature Communications, 8, 2017, 1
Medientyp: E-Article
Sprache: Englisch
veröffentlicht:
Springer Science and Business Media LLC
Schlagwörter:
author_facet Zillikens, M. Carola
Demissie, Serkalem
Hsu, Yi-Hsiang
Yerges-Armstrong, Laura M.
Chou, Wen-Chi
Stolk, Lisette
Livshits, Gregory
Broer, Linda
Johnson, Toby
Koller, Daniel L.
Kutalik, Zoltán
Luan, Jian’an
Malkin, Ida
Ried, Janina S.
Smith, Albert V.
Thorleifsson, Gudmar
Vandenput, Liesbeth
Hua Zhao, Jing
Zhang, Weihua
Aghdassi, Ali
Åkesson, Kristina
Amin, Najaf
Baier, Leslie J.
Barroso, Inês
Bennett, David A.
Bertram, Lars
Biffar, Rainer
Bochud, Murielle
Boehnke, Michael
Borecki, Ingrid B.
Buchman, Aron S.
Byberg, Liisa
Campbell, Harry
Campos Obanda, Natalia
Cauley, Jane A.
Cawthon, Peggy M.
Cederberg, Henna
Chen, Zhao
Cho, Nam H.
Jin Choi, Hyung
Claussnitzer, Melina
Collins, Francis
Cummings, Steven R.
De Jager, Philip L.
Demuth, Ilja
Dhonukshe-Rutten, Rosalie A. M.
Diatchenko, Luda
Eiriksdottir, Gudny
Enneman, Anke W.
Erdos, Mike
Eriksson, Johan G.
Eriksson, Joel
Estrada, Karol
Evans, Daniel S.
Feitosa, Mary F.
Fu, Mao
Garcia, Melissa
Gieger, Christian
Girke, Thomas
Glazer, Nicole L.
Grallert, Harald
Grewal, Jagvir
Han, Bok-Ghee
Hanson, Robert L.
Hayward, Caroline
Hofman, Albert
Hoffman, Eric P.
Homuth, Georg
Hsueh, Wen-Chi
Hubal, Monica J.
Hubbard, Alan
Huffman, Kim M.
Husted, Lise B.
Illig, Thomas
Ingelsson, Erik
Ittermann, Till
Jansson, John-Olov
Jordan, Joanne M.
Jula, Antti
Karlsson, Magnus
Khaw, Kay-Tee
Kilpeläinen, Tuomas O.
Klopp, Norman
Kloth, Jacqueline S. L.
Koistinen, Heikki A.
Kraus, William E.
Kritchevsky, Stephen
Kuulasmaa, Teemu
Kuusisto, Johanna
Laakso, Markku
Lahti, Jari
Lang, Thomas
Langdahl, Bente L.
Launer, Lenore J.
Lee, Jong-Young
Lerch, Markus M.
Lewis, Joshua R.
Lind, Lars
Lindgren, Cecilia
Liu, Yongmei
Liu, Tian
Liu, Youfang
Ljunggren, Östen
Lorentzon, Mattias
Luben, Robert N.
Maixner, William
McGuigan, Fiona E.
Medina-Gomez, Carolina
Meitinger, Thomas
Melhus, Håkan
Mellström, Dan
Melov, Simon
Michaëlsson, Karl
Mitchell, Braxton D.
Morris, Andrew P.
Mosekilde, Leif
Newman, Anne
Nielson, Carrie M.
O’Connell, Jeffrey R.
Oostra, Ben A.
Orwoll, Eric S.
Palotie, Aarno
Parker, Stephen C. J.
Peacock, Munro
Perola, Markus
Peters, Annette
Polasek, Ozren
Prince, Richard L.
Räikkönen, Katri
Ralston, Stuart H.
Ripatti, Samuli
Robbins, John A.
Rotter, Jerome I.
Rudan, Igor
Salomaa, Veikko
Satterfield, Suzanne
Schadt, Eric E.
Schipf, Sabine
Scott, Laura
Sehmi, Joban
Shen, Jian
Soo Shin, Chan
Sigurdsson, Gunnar
Smith, Shad
Soranzo, Nicole
Stančáková, Alena
Steinhagen-Thiessen, Elisabeth
Streeten, Elizabeth A.
Styrkarsdottir, Unnur
Swart, Karin M. A.
Tan, Sian-Tsung
Tarnopolsky, Mark A.
Thompson, Patricia
Thomson, Cynthia A.
Thorsteinsdottir, Unnur
Tikkanen, Emmi
Tranah, Gregory J.
Tuomilehto, Jaakko
van Schoor, Natasja M.
Verma, Arjun
Vollenweider, Peter
Völzke, Henry
Wactawski-Wende, Jean
Walker, Mark
Weedon, Michael N.
Welch, Ryan
Wichmann, H.-Erich
Widen, Elisabeth
Williams, Frances M. K.
Wilson, James F.
Wright, Nicole C.
Xie, Weijia
Yu, Lei
Zhou, Yanhua
Chambers, John C.
Döring, Angela
van Duijn, Cornelia M.
Econs, Michael J.
Gudnason, Vilmundur
Kooner, Jaspal S.
Psaty, Bruce M.
Spector, Timothy D.
Stefansson, Kari
Rivadeneira, Fernando
Uitterlinden, André G.
Wareham, Nicholas J.
Ossowski, Vicky
Waterworth, Dawn
Loos, Ruth J. F.
Karasik, David
Harris, Tamara B.
Ohlsson, Claes
Kiel, Douglas P.
Zillikens, M. Carola
Demissie, Serkalem
Hsu, Yi-Hsiang
Yerges-Armstrong, Laura M.
Chou, Wen-Chi
Stolk, Lisette
Livshits, Gregory
Broer, Linda
Johnson, Toby
Koller, Daniel L.
Kutalik, Zoltán
Luan, Jian’an
Malkin, Ida
Ried, Janina S.
Smith, Albert V.
Thorleifsson, Gudmar
Vandenput, Liesbeth
Hua Zhao, Jing
Zhang, Weihua
Aghdassi, Ali
Åkesson, Kristina
Amin, Najaf
Baier, Leslie J.
Barroso, Inês
Bennett, David A.
Bertram, Lars
Biffar, Rainer
Bochud, Murielle
Boehnke, Michael
Borecki, Ingrid B.
Buchman, Aron S.
Byberg, Liisa
Campbell, Harry
Campos Obanda, Natalia
Cauley, Jane A.
Cawthon, Peggy M.
Cederberg, Henna
Chen, Zhao
Cho, Nam H.
Jin Choi, Hyung
Claussnitzer, Melina
Collins, Francis
Cummings, Steven R.
De Jager, Philip L.
Demuth, Ilja
Dhonukshe-Rutten, Rosalie A. M.
Diatchenko, Luda
Eiriksdottir, Gudny
Enneman, Anke W.
Erdos, Mike
Eriksson, Johan G.
Eriksson, Joel
Estrada, Karol
Evans, Daniel S.
Feitosa, Mary F.
Fu, Mao
Garcia, Melissa
Gieger, Christian
Girke, Thomas
Glazer, Nicole L.
Grallert, Harald
Grewal, Jagvir
Han, Bok-Ghee
Hanson, Robert L.
Hayward, Caroline
Hofman, Albert
Hoffman, Eric P.
Homuth, Georg
Hsueh, Wen-Chi
Hubal, Monica J.
Hubbard, Alan
Huffman, Kim M.
Husted, Lise B.
Illig, Thomas
Ingelsson, Erik
Ittermann, Till
Jansson, John-Olov
Jordan, Joanne M.
Jula, Antti
Karlsson, Magnus
Khaw, Kay-Tee
Kilpeläinen, Tuomas O.
Klopp, Norman
Kloth, Jacqueline S. L.
Koistinen, Heikki A.
Kraus, William E.
Kritchevsky, Stephen
Kuulasmaa, Teemu
Kuusisto, Johanna
Laakso, Markku
Lahti, Jari
Lang, Thomas
Langdahl, Bente L.
Launer, Lenore J.
Lee, Jong-Young
Lerch, Markus M.
Lewis, Joshua R.
Lind, Lars
Lindgren, Cecilia
Liu, Yongmei
Liu, Tian
Liu, Youfang
Ljunggren, Östen
Lorentzon, Mattias
Luben, Robert N.
Maixner, William
McGuigan, Fiona E.
Medina-Gomez, Carolina
Meitinger, Thomas
Melhus, Håkan
Mellström, Dan
Melov, Simon
Michaëlsson, Karl
Mitchell, Braxton D.
Morris, Andrew P.
Mosekilde, Leif
Newman, Anne
Nielson, Carrie M.
O’Connell, Jeffrey R.
Oostra, Ben A.
Orwoll, Eric S.
Palotie, Aarno
Parker, Stephen C. J.
Peacock, Munro
Perola, Markus
Peters, Annette
Polasek, Ozren
Prince, Richard L.
Räikkönen, Katri
Ralston, Stuart H.
Ripatti, Samuli
Robbins, John A.
Rotter, Jerome I.
Rudan, Igor
Salomaa, Veikko
Satterfield, Suzanne
Schadt, Eric E.
Schipf, Sabine
Scott, Laura
Sehmi, Joban
Shen, Jian
Soo Shin, Chan
Sigurdsson, Gunnar
Smith, Shad
Soranzo, Nicole
Stančáková, Alena
Steinhagen-Thiessen, Elisabeth
Streeten, Elizabeth A.
Styrkarsdottir, Unnur
Swart, Karin M. A.
Tan, Sian-Tsung
Tarnopolsky, Mark A.
Thompson, Patricia
Thomson, Cynthia A.
Thorsteinsdottir, Unnur
Tikkanen, Emmi
Tranah, Gregory J.
Tuomilehto, Jaakko
van Schoor, Natasja M.
Verma, Arjun
Vollenweider, Peter
Völzke, Henry
Wactawski-Wende, Jean
Walker, Mark
Weedon, Michael N.
Welch, Ryan
Wichmann, H.-Erich
Widen, Elisabeth
Williams, Frances M. K.
Wilson, James F.
Wright, Nicole C.
Xie, Weijia
Yu, Lei
Zhou, Yanhua
Chambers, John C.
Döring, Angela
van Duijn, Cornelia M.
Econs, Michael J.
Gudnason, Vilmundur
Kooner, Jaspal S.
Psaty, Bruce M.
Spector, Timothy D.
Stefansson, Kari
Rivadeneira, Fernando
Uitterlinden, André G.
Wareham, Nicholas J.
Ossowski, Vicky
Waterworth, Dawn
Loos, Ruth J. F.
Karasik, David
Harris, Tamara B.
Ohlsson, Claes
Kiel, Douglas P.
author Zillikens, M. Carola
Demissie, Serkalem
Hsu, Yi-Hsiang
Yerges-Armstrong, Laura M.
Chou, Wen-Chi
Stolk, Lisette
Livshits, Gregory
Broer, Linda
Johnson, Toby
Koller, Daniel L.
Kutalik, Zoltán
Luan, Jian’an
Malkin, Ida
Ried, Janina S.
Smith, Albert V.
Thorleifsson, Gudmar
Vandenput, Liesbeth
Hua Zhao, Jing
Zhang, Weihua
Aghdassi, Ali
Åkesson, Kristina
Amin, Najaf
Baier, Leslie J.
Barroso, Inês
Bennett, David A.
Bertram, Lars
Biffar, Rainer
Bochud, Murielle
Boehnke, Michael
Borecki, Ingrid B.
Buchman, Aron S.
Byberg, Liisa
Campbell, Harry
Campos Obanda, Natalia
Cauley, Jane A.
Cawthon, Peggy M.
Cederberg, Henna
Chen, Zhao
Cho, Nam H.
Jin Choi, Hyung
Claussnitzer, Melina
Collins, Francis
Cummings, Steven R.
De Jager, Philip L.
Demuth, Ilja
Dhonukshe-Rutten, Rosalie A. M.
Diatchenko, Luda
Eiriksdottir, Gudny
Enneman, Anke W.
Erdos, Mike
Eriksson, Johan G.
Eriksson, Joel
Estrada, Karol
Evans, Daniel S.
Feitosa, Mary F.
Fu, Mao
Garcia, Melissa
Gieger, Christian
Girke, Thomas
Glazer, Nicole L.
Grallert, Harald
Grewal, Jagvir
Han, Bok-Ghee
Hanson, Robert L.
Hayward, Caroline
Hofman, Albert
Hoffman, Eric P.
Homuth, Georg
Hsueh, Wen-Chi
Hubal, Monica J.
Hubbard, Alan
Huffman, Kim M.
Husted, Lise B.
Illig, Thomas
Ingelsson, Erik
Ittermann, Till
Jansson, John-Olov
Jordan, Joanne M.
Jula, Antti
Karlsson, Magnus
Khaw, Kay-Tee
Kilpeläinen, Tuomas O.
Klopp, Norman
Kloth, Jacqueline S. L.
Koistinen, Heikki A.
Kraus, William E.
Kritchevsky, Stephen
Kuulasmaa, Teemu
Kuusisto, Johanna
Laakso, Markku
Lahti, Jari
Lang, Thomas
Langdahl, Bente L.
Launer, Lenore J.
Lee, Jong-Young
Lerch, Markus M.
Lewis, Joshua R.
Lind, Lars
Lindgren, Cecilia
Liu, Yongmei
Liu, Tian
Liu, Youfang
Ljunggren, Östen
Lorentzon, Mattias
Luben, Robert N.
Maixner, William
McGuigan, Fiona E.
Medina-Gomez, Carolina
Meitinger, Thomas
Melhus, Håkan
Mellström, Dan
Melov, Simon
Michaëlsson, Karl
Mitchell, Braxton D.
Morris, Andrew P.
Mosekilde, Leif
Newman, Anne
Nielson, Carrie M.
O’Connell, Jeffrey R.
Oostra, Ben A.
Orwoll, Eric S.
Palotie, Aarno
Parker, Stephen C. J.
Peacock, Munro
Perola, Markus
Peters, Annette
Polasek, Ozren
Prince, Richard L.
Räikkönen, Katri
Ralston, Stuart H.
Ripatti, Samuli
Robbins, John A.
Rotter, Jerome I.
Rudan, Igor
Salomaa, Veikko
Satterfield, Suzanne
Schadt, Eric E.
Schipf, Sabine
Scott, Laura
Sehmi, Joban
Shen, Jian
Soo Shin, Chan
Sigurdsson, Gunnar
Smith, Shad
Soranzo, Nicole
Stančáková, Alena
Steinhagen-Thiessen, Elisabeth
Streeten, Elizabeth A.
Styrkarsdottir, Unnur
Swart, Karin M. A.
Tan, Sian-Tsung
Tarnopolsky, Mark A.
Thompson, Patricia
Thomson, Cynthia A.
Thorsteinsdottir, Unnur
Tikkanen, Emmi
Tranah, Gregory J.
Tuomilehto, Jaakko
van Schoor, Natasja M.
Verma, Arjun
Vollenweider, Peter
Völzke, Henry
Wactawski-Wende, Jean
Walker, Mark
Weedon, Michael N.
Welch, Ryan
Wichmann, H.-Erich
Widen, Elisabeth
Williams, Frances M. K.
Wilson, James F.
Wright, Nicole C.
Xie, Weijia
Yu, Lei
Zhou, Yanhua
Chambers, John C.
Döring, Angela
van Duijn, Cornelia M.
Econs, Michael J.
Gudnason, Vilmundur
Kooner, Jaspal S.
Psaty, Bruce M.
Spector, Timothy D.
Stefansson, Kari
Rivadeneira, Fernando
Uitterlinden, André G.
Wareham, Nicholas J.
Ossowski, Vicky
Waterworth, Dawn
Loos, Ruth J. F.
Karasik, David
Harris, Tamara B.
Ohlsson, Claes
Kiel, Douglas P.
spellingShingle Zillikens, M. Carola
Demissie, Serkalem
Hsu, Yi-Hsiang
Yerges-Armstrong, Laura M.
Chou, Wen-Chi
Stolk, Lisette
Livshits, Gregory
Broer, Linda
Johnson, Toby
Koller, Daniel L.
Kutalik, Zoltán
Luan, Jian’an
Malkin, Ida
Ried, Janina S.
Smith, Albert V.
Thorleifsson, Gudmar
Vandenput, Liesbeth
Hua Zhao, Jing
Zhang, Weihua
Aghdassi, Ali
Åkesson, Kristina
Amin, Najaf
Baier, Leslie J.
Barroso, Inês
Bennett, David A.
Bertram, Lars
Biffar, Rainer
Bochud, Murielle
Boehnke, Michael
Borecki, Ingrid B.
Buchman, Aron S.
Byberg, Liisa
Campbell, Harry
Campos Obanda, Natalia
Cauley, Jane A.
Cawthon, Peggy M.
Cederberg, Henna
Chen, Zhao
Cho, Nam H.
Jin Choi, Hyung
Claussnitzer, Melina
Collins, Francis
Cummings, Steven R.
De Jager, Philip L.
Demuth, Ilja
Dhonukshe-Rutten, Rosalie A. M.
Diatchenko, Luda
Eiriksdottir, Gudny
Enneman, Anke W.
Erdos, Mike
Eriksson, Johan G.
Eriksson, Joel
Estrada, Karol
Evans, Daniel S.
Feitosa, Mary F.
Fu, Mao
Garcia, Melissa
Gieger, Christian
Girke, Thomas
Glazer, Nicole L.
Grallert, Harald
Grewal, Jagvir
Han, Bok-Ghee
Hanson, Robert L.
Hayward, Caroline
Hofman, Albert
Hoffman, Eric P.
Homuth, Georg
Hsueh, Wen-Chi
Hubal, Monica J.
Hubbard, Alan
Huffman, Kim M.
Husted, Lise B.
Illig, Thomas
Ingelsson, Erik
Ittermann, Till
Jansson, John-Olov
Jordan, Joanne M.
Jula, Antti
Karlsson, Magnus
Khaw, Kay-Tee
Kilpeläinen, Tuomas O.
Klopp, Norman
Kloth, Jacqueline S. L.
Koistinen, Heikki A.
Kraus, William E.
Kritchevsky, Stephen
Kuulasmaa, Teemu
Kuusisto, Johanna
Laakso, Markku
Lahti, Jari
Lang, Thomas
Langdahl, Bente L.
Launer, Lenore J.
Lee, Jong-Young
Lerch, Markus M.
Lewis, Joshua R.
Lind, Lars
Lindgren, Cecilia
Liu, Yongmei
Liu, Tian
Liu, Youfang
Ljunggren, Östen
Lorentzon, Mattias
Luben, Robert N.
Maixner, William
McGuigan, Fiona E.
Medina-Gomez, Carolina
Meitinger, Thomas
Melhus, Håkan
Mellström, Dan
Melov, Simon
Michaëlsson, Karl
Mitchell, Braxton D.
Morris, Andrew P.
Mosekilde, Leif
Newman, Anne
Nielson, Carrie M.
O’Connell, Jeffrey R.
Oostra, Ben A.
Orwoll, Eric S.
Palotie, Aarno
Parker, Stephen C. J.
Peacock, Munro
Perola, Markus
Peters, Annette
Polasek, Ozren
Prince, Richard L.
Räikkönen, Katri
Ralston, Stuart H.
Ripatti, Samuli
Robbins, John A.
Rotter, Jerome I.
Rudan, Igor
Salomaa, Veikko
Satterfield, Suzanne
Schadt, Eric E.
Schipf, Sabine
Scott, Laura
Sehmi, Joban
Shen, Jian
Soo Shin, Chan
Sigurdsson, Gunnar
Smith, Shad
Soranzo, Nicole
Stančáková, Alena
Steinhagen-Thiessen, Elisabeth
Streeten, Elizabeth A.
Styrkarsdottir, Unnur
Swart, Karin M. A.
Tan, Sian-Tsung
Tarnopolsky, Mark A.
Thompson, Patricia
Thomson, Cynthia A.
Thorsteinsdottir, Unnur
Tikkanen, Emmi
Tranah, Gregory J.
Tuomilehto, Jaakko
van Schoor, Natasja M.
Verma, Arjun
Vollenweider, Peter
Völzke, Henry
Wactawski-Wende, Jean
Walker, Mark
Weedon, Michael N.
Welch, Ryan
Wichmann, H.-Erich
Widen, Elisabeth
Williams, Frances M. K.
Wilson, James F.
Wright, Nicole C.
Xie, Weijia
Yu, Lei
Zhou, Yanhua
Chambers, John C.
Döring, Angela
van Duijn, Cornelia M.
Econs, Michael J.
Gudnason, Vilmundur
Kooner, Jaspal S.
Psaty, Bruce M.
Spector, Timothy D.
Stefansson, Kari
Rivadeneira, Fernando
Uitterlinden, André G.
Wareham, Nicholas J.
Ossowski, Vicky
Waterworth, Dawn
Loos, Ruth J. F.
Karasik, David
Harris, Tamara B.
Ohlsson, Claes
Kiel, Douglas P.
Nature Communications
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
Multidisciplinary
author_sort zillikens, m. carola
spelling Zillikens, M. Carola Demissie, Serkalem Hsu, Yi-Hsiang Yerges-Armstrong, Laura M. Chou, Wen-Chi Stolk, Lisette Livshits, Gregory Broer, Linda Johnson, Toby Koller, Daniel L. Kutalik, Zoltán Luan, Jian’an Malkin, Ida Ried, Janina S. Smith, Albert V. Thorleifsson, Gudmar Vandenput, Liesbeth Hua Zhao, Jing Zhang, Weihua Aghdassi, Ali Åkesson, Kristina Amin, Najaf Baier, Leslie J. Barroso, Inês Bennett, David A. Bertram, Lars Biffar, Rainer Bochud, Murielle Boehnke, Michael Borecki, Ingrid B. Buchman, Aron S. Byberg, Liisa Campbell, Harry Campos Obanda, Natalia Cauley, Jane A. Cawthon, Peggy M. Cederberg, Henna Chen, Zhao Cho, Nam H. Jin Choi, Hyung Claussnitzer, Melina Collins, Francis Cummings, Steven R. De Jager, Philip L. Demuth, Ilja Dhonukshe-Rutten, Rosalie A. M. Diatchenko, Luda Eiriksdottir, Gudny Enneman, Anke W. Erdos, Mike Eriksson, Johan G. Eriksson, Joel Estrada, Karol Evans, Daniel S. Feitosa, Mary F. Fu, Mao Garcia, Melissa Gieger, Christian Girke, Thomas Glazer, Nicole L. Grallert, Harald Grewal, Jagvir Han, Bok-Ghee Hanson, Robert L. Hayward, Caroline Hofman, Albert Hoffman, Eric P. Homuth, Georg Hsueh, Wen-Chi Hubal, Monica J. Hubbard, Alan Huffman, Kim M. Husted, Lise B. Illig, Thomas Ingelsson, Erik Ittermann, Till Jansson, John-Olov Jordan, Joanne M. Jula, Antti Karlsson, Magnus Khaw, Kay-Tee Kilpeläinen, Tuomas O. Klopp, Norman Kloth, Jacqueline S. L. Koistinen, Heikki A. Kraus, William E. Kritchevsky, Stephen Kuulasmaa, Teemu Kuusisto, Johanna Laakso, Markku Lahti, Jari Lang, Thomas Langdahl, Bente L. Launer, Lenore J. Lee, Jong-Young Lerch, Markus M. Lewis, Joshua R. Lind, Lars Lindgren, Cecilia Liu, Yongmei Liu, Tian Liu, Youfang Ljunggren, Östen Lorentzon, Mattias Luben, Robert N. Maixner, William McGuigan, Fiona E. Medina-Gomez, Carolina Meitinger, Thomas Melhus, Håkan Mellström, Dan Melov, Simon Michaëlsson, Karl Mitchell, Braxton D. Morris, Andrew P. Mosekilde, Leif Newman, Anne Nielson, Carrie M. O’Connell, Jeffrey R. Oostra, Ben A. Orwoll, Eric S. Palotie, Aarno Parker, Stephen C. J. Peacock, Munro Perola, Markus Peters, Annette Polasek, Ozren Prince, Richard L. Räikkönen, Katri Ralston, Stuart H. Ripatti, Samuli Robbins, John A. Rotter, Jerome I. Rudan, Igor Salomaa, Veikko Satterfield, Suzanne Schadt, Eric E. Schipf, Sabine Scott, Laura Sehmi, Joban Shen, Jian Soo Shin, Chan Sigurdsson, Gunnar Smith, Shad Soranzo, Nicole Stančáková, Alena Steinhagen-Thiessen, Elisabeth Streeten, Elizabeth A. Styrkarsdottir, Unnur Swart, Karin M. A. Tan, Sian-Tsung Tarnopolsky, Mark A. Thompson, Patricia Thomson, Cynthia A. Thorsteinsdottir, Unnur Tikkanen, Emmi Tranah, Gregory J. Tuomilehto, Jaakko van Schoor, Natasja M. Verma, Arjun Vollenweider, Peter Völzke, Henry Wactawski-Wende, Jean Walker, Mark Weedon, Michael N. Welch, Ryan Wichmann, H.-Erich Widen, Elisabeth Williams, Frances M. K. Wilson, James F. Wright, Nicole C. Xie, Weijia Yu, Lei Zhou, Yanhua Chambers, John C. Döring, Angela van Duijn, Cornelia M. Econs, Michael J. Gudnason, Vilmundur Kooner, Jaspal S. Psaty, Bruce M. Spector, Timothy D. Stefansson, Kari Rivadeneira, Fernando Uitterlinden, André G. Wareham, Nicholas J. Ossowski, Vicky Waterworth, Dawn Loos, Ruth J. F. Karasik, David Harris, Tamara B. Ohlsson, Claes Kiel, Douglas P. 2041-1723 Springer Science and Business Media LLC General Physics and Astronomy General Biochemistry, Genetics and Molecular Biology General Chemistry Multidisciplinary http://dx.doi.org/10.1038/s41467-017-00031-7 <jats:title>Abstract</jats:title><jats:p>Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with <jats:italic>n</jats:italic> = 38,292) and appendicular (arms and legs) lean body mass (<jats:italic>n</jats:italic> = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (<jats:italic>p</jats:italic> &lt; 5 × 10<jats:sup>−8</jats:sup>) or suggestively genome wide (<jats:italic>p</jats:italic> &lt; 2.3 × 10<jats:sup>−6</jats:sup>). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near <jats:italic>HSD17B11, VCAN, ADAMTSL3</jats:italic>, <jats:italic>IRS1</jats:italic>, and <jats:italic>FTO</jats:italic> for total lean body mass and for three single-nucleotide polymorphisms in/near <jats:italic>VCAN</jats:italic>, <jats:italic>ADAMTSL3</jats:italic>, and <jats:italic>IRS1</jats:italic> for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.</jats:p> Large meta-analysis of genome-wide association studies identifies five loci for lean body mass Nature Communications
doi_str_mv 10.1038/s41467-017-00031-7
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recordtype ai
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series Nature Communications
source_id 49
title Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
title_unstemmed Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
title_full Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
title_fullStr Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
title_full_unstemmed Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
title_short Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
title_sort large meta-analysis of genome-wide association studies identifies five loci for lean body mass
topic General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
Multidisciplinary
url http://dx.doi.org/10.1038/s41467-017-00031-7
publishDate 2017
physical
description <jats:title>Abstract</jats:title><jats:p>Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with <jats:italic>n</jats:italic> = 38,292) and appendicular (arms and legs) lean body mass (<jats:italic>n</jats:italic> = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (<jats:italic>p</jats:italic> &lt; 5 × 10<jats:sup>−8</jats:sup>) or suggestively genome wide (<jats:italic>p</jats:italic> &lt; 2.3 × 10<jats:sup>−6</jats:sup>). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near <jats:italic>HSD17B11, VCAN, ADAMTSL3</jats:italic>, <jats:italic>IRS1</jats:italic>, and <jats:italic>FTO</jats:italic> for total lean body mass and for three single-nucleotide polymorphisms in/near <jats:italic>VCAN</jats:italic>, <jats:italic>ADAMTSL3</jats:italic>, and <jats:italic>IRS1</jats:italic> for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.</jats:p>
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author Zillikens, M. Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M., Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, Jian’an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A. M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong-Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O’Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephen C. J., Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Räikkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Tan, Sian-Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichmann, H.-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J. F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, Kiel, Douglas P.
author_facet Zillikens, M. Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M., Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, Jian’an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A. M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong-Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O’Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephen C. J., Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Räikkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Tan, Sian-Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichmann, H.-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J. F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, Kiel, Douglas P., Zillikens, M. Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M., Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, Jian’an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A. M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong-Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O’Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephen C. J., Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Räikkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Tan, Sian-Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichmann, H.-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J. F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, Kiel, Douglas P.
author_sort zillikens, m. carola
container_issue 1
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description <jats:title>Abstract</jats:title><jats:p>Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with <jats:italic>n</jats:italic> = 38,292) and appendicular (arms and legs) lean body mass (<jats:italic>n</jats:italic> = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (<jats:italic>p</jats:italic> &lt; 5 × 10<jats:sup>−8</jats:sup>) or suggestively genome wide (<jats:italic>p</jats:italic> &lt; 2.3 × 10<jats:sup>−6</jats:sup>). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near <jats:italic>HSD17B11, VCAN, ADAMTSL3</jats:italic>, <jats:italic>IRS1</jats:italic>, and <jats:italic>FTO</jats:italic> for total lean body mass and for three single-nucleotide polymorphisms in/near <jats:italic>VCAN</jats:italic>, <jats:italic>ADAMTSL3</jats:italic>, and <jats:italic>IRS1</jats:italic> for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.</jats:p>
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publishDateSort 2017
publisher Springer Science and Business Media LLC
record_format ai
recordtype ai
series Nature Communications
source_id 49
spelling Zillikens, M. Carola Demissie, Serkalem Hsu, Yi-Hsiang Yerges-Armstrong, Laura M. Chou, Wen-Chi Stolk, Lisette Livshits, Gregory Broer, Linda Johnson, Toby Koller, Daniel L. Kutalik, Zoltán Luan, Jian’an Malkin, Ida Ried, Janina S. Smith, Albert V. Thorleifsson, Gudmar Vandenput, Liesbeth Hua Zhao, Jing Zhang, Weihua Aghdassi, Ali Åkesson, Kristina Amin, Najaf Baier, Leslie J. Barroso, Inês Bennett, David A. Bertram, Lars Biffar, Rainer Bochud, Murielle Boehnke, Michael Borecki, Ingrid B. Buchman, Aron S. Byberg, Liisa Campbell, Harry Campos Obanda, Natalia Cauley, Jane A. Cawthon, Peggy M. Cederberg, Henna Chen, Zhao Cho, Nam H. Jin Choi, Hyung Claussnitzer, Melina Collins, Francis Cummings, Steven R. De Jager, Philip L. Demuth, Ilja Dhonukshe-Rutten, Rosalie A. M. Diatchenko, Luda Eiriksdottir, Gudny Enneman, Anke W. Erdos, Mike Eriksson, Johan G. Eriksson, Joel Estrada, Karol Evans, Daniel S. Feitosa, Mary F. Fu, Mao Garcia, Melissa Gieger, Christian Girke, Thomas Glazer, Nicole L. Grallert, Harald Grewal, Jagvir Han, Bok-Ghee Hanson, Robert L. Hayward, Caroline Hofman, Albert Hoffman, Eric P. Homuth, Georg Hsueh, Wen-Chi Hubal, Monica J. Hubbard, Alan Huffman, Kim M. Husted, Lise B. Illig, Thomas Ingelsson, Erik Ittermann, Till Jansson, John-Olov Jordan, Joanne M. Jula, Antti Karlsson, Magnus Khaw, Kay-Tee Kilpeläinen, Tuomas O. Klopp, Norman Kloth, Jacqueline S. L. Koistinen, Heikki A. Kraus, William E. Kritchevsky, Stephen Kuulasmaa, Teemu Kuusisto, Johanna Laakso, Markku Lahti, Jari Lang, Thomas Langdahl, Bente L. Launer, Lenore J. Lee, Jong-Young Lerch, Markus M. Lewis, Joshua R. Lind, Lars Lindgren, Cecilia Liu, Yongmei Liu, Tian Liu, Youfang Ljunggren, Östen Lorentzon, Mattias Luben, Robert N. Maixner, William McGuigan, Fiona E. Medina-Gomez, Carolina Meitinger, Thomas Melhus, Håkan Mellström, Dan Melov, Simon Michaëlsson, Karl Mitchell, Braxton D. Morris, Andrew P. Mosekilde, Leif Newman, Anne Nielson, Carrie M. O’Connell, Jeffrey R. Oostra, Ben A. Orwoll, Eric S. Palotie, Aarno Parker, Stephen C. J. Peacock, Munro Perola, Markus Peters, Annette Polasek, Ozren Prince, Richard L. Räikkönen, Katri Ralston, Stuart H. Ripatti, Samuli Robbins, John A. Rotter, Jerome I. Rudan, Igor Salomaa, Veikko Satterfield, Suzanne Schadt, Eric E. Schipf, Sabine Scott, Laura Sehmi, Joban Shen, Jian Soo Shin, Chan Sigurdsson, Gunnar Smith, Shad Soranzo, Nicole Stančáková, Alena Steinhagen-Thiessen, Elisabeth Streeten, Elizabeth A. Styrkarsdottir, Unnur Swart, Karin M. A. Tan, Sian-Tsung Tarnopolsky, Mark A. Thompson, Patricia Thomson, Cynthia A. Thorsteinsdottir, Unnur Tikkanen, Emmi Tranah, Gregory J. Tuomilehto, Jaakko van Schoor, Natasja M. Verma, Arjun Vollenweider, Peter Völzke, Henry Wactawski-Wende, Jean Walker, Mark Weedon, Michael N. Welch, Ryan Wichmann, H.-Erich Widen, Elisabeth Williams, Frances M. K. Wilson, James F. Wright, Nicole C. Xie, Weijia Yu, Lei Zhou, Yanhua Chambers, John C. Döring, Angela van Duijn, Cornelia M. Econs, Michael J. Gudnason, Vilmundur Kooner, Jaspal S. Psaty, Bruce M. Spector, Timothy D. Stefansson, Kari Rivadeneira, Fernando Uitterlinden, André G. Wareham, Nicholas J. Ossowski, Vicky Waterworth, Dawn Loos, Ruth J. F. Karasik, David Harris, Tamara B. Ohlsson, Claes Kiel, Douglas P. 2041-1723 Springer Science and Business Media LLC General Physics and Astronomy General Biochemistry, Genetics and Molecular Biology General Chemistry Multidisciplinary http://dx.doi.org/10.1038/s41467-017-00031-7 <jats:title>Abstract</jats:title><jats:p>Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with <jats:italic>n</jats:italic> = 38,292) and appendicular (arms and legs) lean body mass (<jats:italic>n</jats:italic> = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (<jats:italic>p</jats:italic> &lt; 5 × 10<jats:sup>−8</jats:sup>) or suggestively genome wide (<jats:italic>p</jats:italic> &lt; 2.3 × 10<jats:sup>−6</jats:sup>). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near <jats:italic>HSD17B11, VCAN, ADAMTSL3</jats:italic>, <jats:italic>IRS1</jats:italic>, and <jats:italic>FTO</jats:italic> for total lean body mass and for three single-nucleotide polymorphisms in/near <jats:italic>VCAN</jats:italic>, <jats:italic>ADAMTSL3</jats:italic>, and <jats:italic>IRS1</jats:italic> for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.</jats:p> Large meta-analysis of genome-wide association studies identifies five loci for lean body mass Nature Communications
spellingShingle Zillikens, M. Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M., Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, Jian’an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A. M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong-Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O’Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephen C. J., Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Räikkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Tan, Sian-Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichmann, H.-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J. F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, Kiel, Douglas P., Nature Communications, Large meta-analysis of genome-wide association studies identifies five loci for lean body mass, General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary
title Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
title_full Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
title_fullStr Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
title_full_unstemmed Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
title_short Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
title_sort large meta-analysis of genome-wide association studies identifies five loci for lean body mass
title_unstemmed Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
topic General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary
url http://dx.doi.org/10.1038/s41467-017-00031-7