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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
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Zeitschriftentitel: | Nature Communications |
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In: | Nature Communications, 8, 2017, 1 |
Medientyp: | E-Article |
Sprache: | Englisch |
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Springer Science and Business Media LLC
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author_facet |
Zillikens, M. Carola Demissie, Serkalem Hsu, Yi-Hsiang Yerges-Armstrong, Laura M. Chou, Wen-Chi Stolk, Lisette Livshits, Gregory Broer, Linda Johnson, Toby Koller, Daniel L. Kutalik, Zoltán Luan, Jian’an Malkin, Ida Ried, Janina S. Smith, Albert V. Thorleifsson, Gudmar Vandenput, Liesbeth Hua Zhao, Jing Zhang, Weihua Aghdassi, Ali Åkesson, Kristina Amin, Najaf Baier, Leslie J. Barroso, Inês Bennett, David A. Bertram, Lars Biffar, Rainer Bochud, Murielle Boehnke, Michael Borecki, Ingrid B. Buchman, Aron S. Byberg, Liisa Campbell, Harry Campos Obanda, Natalia Cauley, Jane A. Cawthon, Peggy M. Cederberg, Henna Chen, Zhao Cho, Nam H. Jin Choi, Hyung Claussnitzer, Melina Collins, Francis Cummings, Steven R. De Jager, Philip L. Demuth, Ilja Dhonukshe-Rutten, Rosalie A. M. Diatchenko, Luda Eiriksdottir, Gudny Enneman, Anke W. Erdos, Mike Eriksson, Johan G. Eriksson, Joel Estrada, Karol Evans, Daniel S. Feitosa, Mary F. Fu, Mao Garcia, Melissa Gieger, Christian Girke, Thomas Glazer, Nicole L. Grallert, Harald Grewal, Jagvir Han, Bok-Ghee Hanson, Robert L. Hayward, Caroline Hofman, Albert Hoffman, Eric P. Homuth, Georg Hsueh, Wen-Chi Hubal, Monica J. Hubbard, Alan Huffman, Kim M. Husted, Lise B. Illig, Thomas Ingelsson, Erik Ittermann, Till Jansson, John-Olov Jordan, Joanne M. Jula, Antti Karlsson, Magnus Khaw, Kay-Tee Kilpeläinen, Tuomas O. Klopp, Norman Kloth, Jacqueline S. L. Koistinen, Heikki A. Kraus, William E. Kritchevsky, Stephen Kuulasmaa, Teemu Kuusisto, Johanna Laakso, Markku Lahti, Jari Lang, Thomas Langdahl, Bente L. Launer, Lenore J. Lee, Jong-Young Lerch, Markus M. Lewis, Joshua R. Lind, Lars Lindgren, Cecilia Liu, Yongmei Liu, Tian Liu, Youfang Ljunggren, Östen Lorentzon, Mattias Luben, Robert N. Maixner, William McGuigan, Fiona E. Medina-Gomez, Carolina Meitinger, Thomas Melhus, Håkan Mellström, Dan Melov, Simon Michaëlsson, Karl Mitchell, Braxton D. Morris, Andrew P. Mosekilde, Leif Newman, Anne Nielson, Carrie M. O’Connell, Jeffrey R. Oostra, Ben A. Orwoll, Eric S. Palotie, Aarno Parker, Stephen C. J. Peacock, Munro Perola, Markus Peters, Annette Polasek, Ozren Prince, Richard L. Räikkönen, Katri Ralston, Stuart H. Ripatti, Samuli Robbins, John A. Rotter, Jerome I. Rudan, Igor Salomaa, Veikko Satterfield, Suzanne Schadt, Eric E. Schipf, Sabine Scott, Laura Sehmi, Joban Shen, Jian Soo Shin, Chan Sigurdsson, Gunnar Smith, Shad Soranzo, Nicole Stančáková, Alena Steinhagen-Thiessen, Elisabeth Streeten, Elizabeth A. Styrkarsdottir, Unnur Swart, Karin M. A. Tan, Sian-Tsung Tarnopolsky, Mark A. Thompson, Patricia Thomson, Cynthia A. Thorsteinsdottir, Unnur Tikkanen, Emmi Tranah, Gregory J. Tuomilehto, Jaakko van Schoor, Natasja M. Verma, Arjun Vollenweider, Peter Völzke, Henry Wactawski-Wende, Jean Walker, Mark Weedon, Michael N. Welch, Ryan Wichmann, H.-Erich Widen, Elisabeth Williams, Frances M. K. Wilson, James F. Wright, Nicole C. Xie, Weijia Yu, Lei Zhou, Yanhua Chambers, John C. Döring, Angela van Duijn, Cornelia M. Econs, Michael J. Gudnason, Vilmundur Kooner, Jaspal S. Psaty, Bruce M. Spector, Timothy D. Stefansson, Kari Rivadeneira, Fernando Uitterlinden, André G. Wareham, Nicholas J. Ossowski, Vicky Waterworth, Dawn Loos, Ruth J. F. Karasik, David Harris, Tamara B. Ohlsson, Claes Kiel, Douglas P. Zillikens, M. Carola Demissie, Serkalem Hsu, Yi-Hsiang Yerges-Armstrong, Laura M. Chou, Wen-Chi Stolk, Lisette Livshits, Gregory Broer, Linda Johnson, Toby Koller, Daniel L. Kutalik, Zoltán Luan, Jian’an Malkin, Ida Ried, Janina S. Smith, Albert V. Thorleifsson, Gudmar Vandenput, Liesbeth Hua Zhao, Jing Zhang, Weihua Aghdassi, Ali Åkesson, Kristina Amin, Najaf Baier, Leslie J. Barroso, Inês Bennett, David A. Bertram, Lars Biffar, Rainer Bochud, Murielle Boehnke, Michael Borecki, Ingrid B. Buchman, Aron S. Byberg, Liisa Campbell, Harry Campos Obanda, Natalia Cauley, Jane A. Cawthon, Peggy M. Cederberg, Henna Chen, Zhao Cho, Nam H. Jin Choi, Hyung Claussnitzer, Melina Collins, Francis Cummings, Steven R. De Jager, Philip L. Demuth, Ilja Dhonukshe-Rutten, Rosalie A. M. Diatchenko, Luda Eiriksdottir, Gudny Enneman, Anke W. Erdos, Mike Eriksson, Johan G. Eriksson, Joel Estrada, Karol Evans, Daniel S. Feitosa, Mary F. Fu, Mao Garcia, Melissa Gieger, Christian Girke, Thomas Glazer, Nicole L. Grallert, Harald Grewal, Jagvir Han, Bok-Ghee Hanson, Robert L. Hayward, Caroline Hofman, Albert Hoffman, Eric P. Homuth, Georg Hsueh, Wen-Chi Hubal, Monica J. Hubbard, Alan Huffman, Kim M. Husted, Lise B. Illig, Thomas Ingelsson, Erik Ittermann, Till Jansson, John-Olov Jordan, Joanne M. Jula, Antti Karlsson, Magnus Khaw, Kay-Tee Kilpeläinen, Tuomas O. Klopp, Norman Kloth, Jacqueline S. L. Koistinen, Heikki A. Kraus, William E. Kritchevsky, Stephen Kuulasmaa, Teemu Kuusisto, Johanna Laakso, Markku Lahti, Jari Lang, Thomas Langdahl, Bente L. Launer, Lenore J. Lee, Jong-Young Lerch, Markus M. Lewis, Joshua R. Lind, Lars Lindgren, Cecilia Liu, Yongmei Liu, Tian Liu, Youfang Ljunggren, Östen Lorentzon, Mattias Luben, Robert N. Maixner, William McGuigan, Fiona E. Medina-Gomez, Carolina Meitinger, Thomas Melhus, Håkan Mellström, Dan Melov, Simon Michaëlsson, Karl Mitchell, Braxton D. Morris, Andrew P. Mosekilde, Leif Newman, Anne Nielson, Carrie M. O’Connell, Jeffrey R. Oostra, Ben A. Orwoll, Eric S. Palotie, Aarno Parker, Stephen C. J. Peacock, Munro Perola, Markus Peters, Annette Polasek, Ozren Prince, Richard L. Räikkönen, Katri Ralston, Stuart H. Ripatti, Samuli Robbins, John A. Rotter, Jerome I. Rudan, Igor Salomaa, Veikko Satterfield, Suzanne Schadt, Eric E. Schipf, Sabine Scott, Laura Sehmi, Joban Shen, Jian Soo Shin, Chan Sigurdsson, Gunnar Smith, Shad Soranzo, Nicole Stančáková, Alena Steinhagen-Thiessen, Elisabeth Streeten, Elizabeth A. Styrkarsdottir, Unnur Swart, Karin M. A. Tan, Sian-Tsung Tarnopolsky, Mark A. Thompson, Patricia Thomson, Cynthia A. Thorsteinsdottir, Unnur Tikkanen, Emmi Tranah, Gregory J. Tuomilehto, Jaakko van Schoor, Natasja M. Verma, Arjun Vollenweider, Peter Völzke, Henry Wactawski-Wende, Jean Walker, Mark Weedon, Michael N. Welch, Ryan Wichmann, H.-Erich Widen, Elisabeth Williams, Frances M. K. Wilson, James F. Wright, Nicole C. Xie, Weijia Yu, Lei Zhou, Yanhua Chambers, John C. Döring, Angela van Duijn, Cornelia M. Econs, Michael J. Gudnason, Vilmundur Kooner, Jaspal S. Psaty, Bruce M. Spector, Timothy D. Stefansson, Kari Rivadeneira, Fernando Uitterlinden, André G. Wareham, Nicholas J. Ossowski, Vicky Waterworth, Dawn Loos, Ruth J. F. Karasik, David Harris, Tamara B. Ohlsson, Claes Kiel, Douglas P. |
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author |
Zillikens, M. Carola Demissie, Serkalem Hsu, Yi-Hsiang Yerges-Armstrong, Laura M. Chou, Wen-Chi Stolk, Lisette Livshits, Gregory Broer, Linda Johnson, Toby Koller, Daniel L. Kutalik, Zoltán Luan, Jian’an Malkin, Ida Ried, Janina S. Smith, Albert V. Thorleifsson, Gudmar Vandenput, Liesbeth Hua Zhao, Jing Zhang, Weihua Aghdassi, Ali Åkesson, Kristina Amin, Najaf Baier, Leslie J. Barroso, Inês Bennett, David A. Bertram, Lars Biffar, Rainer Bochud, Murielle Boehnke, Michael Borecki, Ingrid B. Buchman, Aron S. Byberg, Liisa Campbell, Harry Campos Obanda, Natalia Cauley, Jane A. Cawthon, Peggy M. Cederberg, Henna Chen, Zhao Cho, Nam H. Jin Choi, Hyung Claussnitzer, Melina Collins, Francis Cummings, Steven R. De Jager, Philip L. Demuth, Ilja Dhonukshe-Rutten, Rosalie A. M. Diatchenko, Luda Eiriksdottir, Gudny Enneman, Anke W. Erdos, Mike Eriksson, Johan G. Eriksson, Joel Estrada, Karol Evans, Daniel S. Feitosa, Mary F. Fu, Mao Garcia, Melissa Gieger, Christian Girke, Thomas Glazer, Nicole L. Grallert, Harald Grewal, Jagvir Han, Bok-Ghee Hanson, Robert L. Hayward, Caroline Hofman, Albert Hoffman, Eric P. Homuth, Georg Hsueh, Wen-Chi Hubal, Monica J. Hubbard, Alan Huffman, Kim M. Husted, Lise B. Illig, Thomas Ingelsson, Erik Ittermann, Till Jansson, John-Olov Jordan, Joanne M. Jula, Antti Karlsson, Magnus Khaw, Kay-Tee Kilpeläinen, Tuomas O. Klopp, Norman Kloth, Jacqueline S. L. Koistinen, Heikki A. Kraus, William E. Kritchevsky, Stephen Kuulasmaa, Teemu Kuusisto, Johanna Laakso, Markku Lahti, Jari Lang, Thomas Langdahl, Bente L. Launer, Lenore J. Lee, Jong-Young Lerch, Markus M. Lewis, Joshua R. Lind, Lars Lindgren, Cecilia Liu, Yongmei Liu, Tian Liu, Youfang Ljunggren, Östen Lorentzon, Mattias Luben, Robert N. Maixner, William McGuigan, Fiona E. Medina-Gomez, Carolina Meitinger, Thomas Melhus, Håkan Mellström, Dan Melov, Simon Michaëlsson, Karl Mitchell, Braxton D. Morris, Andrew P. Mosekilde, Leif Newman, Anne Nielson, Carrie M. O’Connell, Jeffrey R. Oostra, Ben A. Orwoll, Eric S. Palotie, Aarno Parker, Stephen C. J. Peacock, Munro Perola, Markus Peters, Annette Polasek, Ozren Prince, Richard L. Räikkönen, Katri Ralston, Stuart H. Ripatti, Samuli Robbins, John A. Rotter, Jerome I. Rudan, Igor Salomaa, Veikko Satterfield, Suzanne Schadt, Eric E. Schipf, Sabine Scott, Laura Sehmi, Joban Shen, Jian Soo Shin, Chan Sigurdsson, Gunnar Smith, Shad Soranzo, Nicole Stančáková, Alena Steinhagen-Thiessen, Elisabeth Streeten, Elizabeth A. Styrkarsdottir, Unnur Swart, Karin M. A. Tan, Sian-Tsung Tarnopolsky, Mark A. Thompson, Patricia Thomson, Cynthia A. Thorsteinsdottir, Unnur Tikkanen, Emmi Tranah, Gregory J. Tuomilehto, Jaakko van Schoor, Natasja M. Verma, Arjun Vollenweider, Peter Völzke, Henry Wactawski-Wende, Jean Walker, Mark Weedon, Michael N. Welch, Ryan Wichmann, H.-Erich Widen, Elisabeth Williams, Frances M. K. Wilson, James F. Wright, Nicole C. Xie, Weijia Yu, Lei Zhou, Yanhua Chambers, John C. Döring, Angela van Duijn, Cornelia M. Econs, Michael J. Gudnason, Vilmundur Kooner, Jaspal S. Psaty, Bruce M. Spector, Timothy D. Stefansson, Kari Rivadeneira, Fernando Uitterlinden, André G. Wareham, Nicholas J. Ossowski, Vicky Waterworth, Dawn Loos, Ruth J. F. Karasik, David Harris, Tamara B. Ohlsson, Claes Kiel, Douglas P. |
spellingShingle |
Zillikens, M. Carola Demissie, Serkalem Hsu, Yi-Hsiang Yerges-Armstrong, Laura M. Chou, Wen-Chi Stolk, Lisette Livshits, Gregory Broer, Linda Johnson, Toby Koller, Daniel L. Kutalik, Zoltán Luan, Jian’an Malkin, Ida Ried, Janina S. Smith, Albert V. Thorleifsson, Gudmar Vandenput, Liesbeth Hua Zhao, Jing Zhang, Weihua Aghdassi, Ali Åkesson, Kristina Amin, Najaf Baier, Leslie J. Barroso, Inês Bennett, David A. Bertram, Lars Biffar, Rainer Bochud, Murielle Boehnke, Michael Borecki, Ingrid B. Buchman, Aron S. Byberg, Liisa Campbell, Harry Campos Obanda, Natalia Cauley, Jane A. Cawthon, Peggy M. Cederberg, Henna Chen, Zhao Cho, Nam H. Jin Choi, Hyung Claussnitzer, Melina Collins, Francis Cummings, Steven R. De Jager, Philip L. Demuth, Ilja Dhonukshe-Rutten, Rosalie A. M. Diatchenko, Luda Eiriksdottir, Gudny Enneman, Anke W. Erdos, Mike Eriksson, Johan G. Eriksson, Joel Estrada, Karol Evans, Daniel S. Feitosa, Mary F. Fu, Mao Garcia, Melissa Gieger, Christian Girke, Thomas Glazer, Nicole L. Grallert, Harald Grewal, Jagvir Han, Bok-Ghee Hanson, Robert L. Hayward, Caroline Hofman, Albert Hoffman, Eric P. Homuth, Georg Hsueh, Wen-Chi Hubal, Monica J. Hubbard, Alan Huffman, Kim M. Husted, Lise B. Illig, Thomas Ingelsson, Erik Ittermann, Till Jansson, John-Olov Jordan, Joanne M. Jula, Antti Karlsson, Magnus Khaw, Kay-Tee Kilpeläinen, Tuomas O. Klopp, Norman Kloth, Jacqueline S. L. Koistinen, Heikki A. Kraus, William E. Kritchevsky, Stephen Kuulasmaa, Teemu Kuusisto, Johanna Laakso, Markku Lahti, Jari Lang, Thomas Langdahl, Bente L. Launer, Lenore J. Lee, Jong-Young Lerch, Markus M. Lewis, Joshua R. Lind, Lars Lindgren, Cecilia Liu, Yongmei Liu, Tian Liu, Youfang Ljunggren, Östen Lorentzon, Mattias Luben, Robert N. Maixner, William McGuigan, Fiona E. Medina-Gomez, Carolina Meitinger, Thomas Melhus, Håkan Mellström, Dan Melov, Simon Michaëlsson, Karl Mitchell, Braxton D. Morris, Andrew P. Mosekilde, Leif Newman, Anne Nielson, Carrie M. O’Connell, Jeffrey R. Oostra, Ben A. Orwoll, Eric S. Palotie, Aarno Parker, Stephen C. J. Peacock, Munro Perola, Markus Peters, Annette Polasek, Ozren Prince, Richard L. Räikkönen, Katri Ralston, Stuart H. Ripatti, Samuli Robbins, John A. Rotter, Jerome I. Rudan, Igor Salomaa, Veikko Satterfield, Suzanne Schadt, Eric E. Schipf, Sabine Scott, Laura Sehmi, Joban Shen, Jian Soo Shin, Chan Sigurdsson, Gunnar Smith, Shad Soranzo, Nicole Stančáková, Alena Steinhagen-Thiessen, Elisabeth Streeten, Elizabeth A. Styrkarsdottir, Unnur Swart, Karin M. A. Tan, Sian-Tsung Tarnopolsky, Mark A. Thompson, Patricia Thomson, Cynthia A. Thorsteinsdottir, Unnur Tikkanen, Emmi Tranah, Gregory J. Tuomilehto, Jaakko van Schoor, Natasja M. Verma, Arjun Vollenweider, Peter Völzke, Henry Wactawski-Wende, Jean Walker, Mark Weedon, Michael N. Welch, Ryan Wichmann, H.-Erich Widen, Elisabeth Williams, Frances M. K. Wilson, James F. Wright, Nicole C. Xie, Weijia Yu, Lei Zhou, Yanhua Chambers, John C. Döring, Angela van Duijn, Cornelia M. Econs, Michael J. Gudnason, Vilmundur Kooner, Jaspal S. Psaty, Bruce M. Spector, Timothy D. Stefansson, Kari Rivadeneira, Fernando Uitterlinden, André G. Wareham, Nicholas J. Ossowski, Vicky Waterworth, Dawn Loos, Ruth J. F. Karasik, David Harris, Tamara B. Ohlsson, Claes Kiel, Douglas P. Nature Communications Large meta-analysis of genome-wide association studies identifies five loci for lean body mass General Physics and Astronomy General Biochemistry, Genetics and Molecular Biology General Chemistry Multidisciplinary |
author_sort |
zillikens, m. carola |
spelling |
Zillikens, M. Carola Demissie, Serkalem Hsu, Yi-Hsiang Yerges-Armstrong, Laura M. Chou, Wen-Chi Stolk, Lisette Livshits, Gregory Broer, Linda Johnson, Toby Koller, Daniel L. Kutalik, Zoltán Luan, Jian’an Malkin, Ida Ried, Janina S. Smith, Albert V. Thorleifsson, Gudmar Vandenput, Liesbeth Hua Zhao, Jing Zhang, Weihua Aghdassi, Ali Åkesson, Kristina Amin, Najaf Baier, Leslie J. Barroso, Inês Bennett, David A. Bertram, Lars Biffar, Rainer Bochud, Murielle Boehnke, Michael Borecki, Ingrid B. Buchman, Aron S. Byberg, Liisa Campbell, Harry Campos Obanda, Natalia Cauley, Jane A. Cawthon, Peggy M. Cederberg, Henna Chen, Zhao Cho, Nam H. Jin Choi, Hyung Claussnitzer, Melina Collins, Francis Cummings, Steven R. De Jager, Philip L. Demuth, Ilja Dhonukshe-Rutten, Rosalie A. M. Diatchenko, Luda Eiriksdottir, Gudny Enneman, Anke W. Erdos, Mike Eriksson, Johan G. Eriksson, Joel Estrada, Karol Evans, Daniel S. Feitosa, Mary F. Fu, Mao Garcia, Melissa Gieger, Christian Girke, Thomas Glazer, Nicole L. Grallert, Harald Grewal, Jagvir Han, Bok-Ghee Hanson, Robert L. Hayward, Caroline Hofman, Albert Hoffman, Eric P. Homuth, Georg Hsueh, Wen-Chi Hubal, Monica J. Hubbard, Alan Huffman, Kim M. Husted, Lise B. Illig, Thomas Ingelsson, Erik Ittermann, Till Jansson, John-Olov Jordan, Joanne M. Jula, Antti Karlsson, Magnus Khaw, Kay-Tee Kilpeläinen, Tuomas O. Klopp, Norman Kloth, Jacqueline S. L. Koistinen, Heikki A. Kraus, William E. Kritchevsky, Stephen Kuulasmaa, Teemu Kuusisto, Johanna Laakso, Markku Lahti, Jari Lang, Thomas Langdahl, Bente L. Launer, Lenore J. Lee, Jong-Young Lerch, Markus M. Lewis, Joshua R. Lind, Lars Lindgren, Cecilia Liu, Yongmei Liu, Tian Liu, Youfang Ljunggren, Östen Lorentzon, Mattias Luben, Robert N. Maixner, William McGuigan, Fiona E. Medina-Gomez, Carolina Meitinger, Thomas Melhus, Håkan Mellström, Dan Melov, Simon Michaëlsson, Karl Mitchell, Braxton D. Morris, Andrew P. Mosekilde, Leif Newman, Anne Nielson, Carrie M. O’Connell, Jeffrey R. Oostra, Ben A. Orwoll, Eric S. Palotie, Aarno Parker, Stephen C. J. Peacock, Munro Perola, Markus Peters, Annette Polasek, Ozren Prince, Richard L. Räikkönen, Katri Ralston, Stuart H. Ripatti, Samuli Robbins, John A. Rotter, Jerome I. Rudan, Igor Salomaa, Veikko Satterfield, Suzanne Schadt, Eric E. Schipf, Sabine Scott, Laura Sehmi, Joban Shen, Jian Soo Shin, Chan Sigurdsson, Gunnar Smith, Shad Soranzo, Nicole Stančáková, Alena Steinhagen-Thiessen, Elisabeth Streeten, Elizabeth A. Styrkarsdottir, Unnur Swart, Karin M. A. Tan, Sian-Tsung Tarnopolsky, Mark A. Thompson, Patricia Thomson, Cynthia A. Thorsteinsdottir, Unnur Tikkanen, Emmi Tranah, Gregory J. Tuomilehto, Jaakko van Schoor, Natasja M. Verma, Arjun Vollenweider, Peter Völzke, Henry Wactawski-Wende, Jean Walker, Mark Weedon, Michael N. Welch, Ryan Wichmann, H.-Erich Widen, Elisabeth Williams, Frances M. K. Wilson, James F. Wright, Nicole C. Xie, Weijia Yu, Lei Zhou, Yanhua Chambers, John C. Döring, Angela van Duijn, Cornelia M. Econs, Michael J. Gudnason, Vilmundur Kooner, Jaspal S. Psaty, Bruce M. Spector, Timothy D. Stefansson, Kari Rivadeneira, Fernando Uitterlinden, André G. Wareham, Nicholas J. Ossowski, Vicky Waterworth, Dawn Loos, Ruth J. F. Karasik, David Harris, Tamara B. Ohlsson, Claes Kiel, Douglas P. 2041-1723 Springer Science and Business Media LLC General Physics and Astronomy General Biochemistry, Genetics and Molecular Biology General Chemistry Multidisciplinary http://dx.doi.org/10.1038/s41467-017-00031-7 <jats:title>Abstract</jats:title><jats:p>Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with <jats:italic>n</jats:italic> = 38,292) and appendicular (arms and legs) lean body mass (<jats:italic>n</jats:italic> = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (<jats:italic>p</jats:italic> < 5 × 10<jats:sup>−8</jats:sup>) or suggestively genome wide (<jats:italic>p</jats:italic> < 2.3 × 10<jats:sup>−6</jats:sup>). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near <jats:italic>HSD17B11, VCAN, ADAMTSL3</jats:italic>, <jats:italic>IRS1</jats:italic>, and <jats:italic>FTO</jats:italic> for total lean body mass and for three single-nucleotide polymorphisms in/near <jats:italic>VCAN</jats:italic>, <jats:italic>ADAMTSL3</jats:italic>, and <jats:italic>IRS1</jats:italic> for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.</jats:p> Large meta-analysis of genome-wide association studies identifies five loci for lean body mass Nature Communications |
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10.1038/s41467-017-00031-7 |
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2017 |
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Springer Science and Business Media LLC |
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Nature Communications |
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49 |
title |
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
title_unstemmed |
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
title_full |
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
title_fullStr |
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
title_full_unstemmed |
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
title_short |
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
title_sort |
large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
topic |
General Physics and Astronomy General Biochemistry, Genetics and Molecular Biology General Chemistry Multidisciplinary |
url |
http://dx.doi.org/10.1038/s41467-017-00031-7 |
publishDate |
2017 |
physical |
|
description |
<jats:title>Abstract</jats:title><jats:p>Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with <jats:italic>n</jats:italic> = 38,292) and appendicular (arms and legs) lean body mass (<jats:italic>n</jats:italic> = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (<jats:italic>p</jats:italic> < 5 × 10<jats:sup>−8</jats:sup>) or suggestively genome wide (<jats:italic>p</jats:italic> < 2.3 × 10<jats:sup>−6</jats:sup>). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near <jats:italic>HSD17B11, VCAN, ADAMTSL3</jats:italic>, <jats:italic>IRS1</jats:italic>, and <jats:italic>FTO</jats:italic> for total lean body mass and for three single-nucleotide polymorphisms in/near <jats:italic>VCAN</jats:italic>, <jats:italic>ADAMTSL3</jats:italic>, and <jats:italic>IRS1</jats:italic> for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.</jats:p> |
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author | Zillikens, M. Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M., Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, Jian’an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A. M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong-Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O’Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephen C. J., Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Räikkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Tan, Sian-Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichmann, H.-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J. F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, Kiel, Douglas P. |
author_facet | Zillikens, M. Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M., Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, Jian’an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A. M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong-Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O’Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephen C. J., Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Räikkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Tan, Sian-Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichmann, H.-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J. F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, Kiel, Douglas P., Zillikens, M. Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M., Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, Jian’an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J., Barroso, Inês, Bennett, David A., Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B., Buchman, Aron S., Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A., Cawthon, Peggy M., Cederberg, Henna, Chen, Zhao, Cho, Nam H., Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R., De Jager, Philip L., Demuth, Ilja, Dhonukshe-Rutten, Rosalie A. M., Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W., Erdos, Mike, Eriksson, Johan G., Eriksson, Joel, Estrada, Karol, Evans, Daniel S., Feitosa, Mary F., Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L., Hayward, Caroline, Hofman, Albert, Hoffman, Eric P., Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J., Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M., Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O., Klopp, Norman, Kloth, Jacqueline S. L., Koistinen, Heikki A., Kraus, William E., Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Launer, Lenore J., Lee, Jong-Young, Lerch, Markus M., Lewis, Joshua R., Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Liu, Tian, Liu, Youfang, Ljunggren, Östen, Lorentzon, Mattias, Luben, Robert N., Maixner, William, McGuigan, Fiona E., Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Melov, Simon, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, Nielson, Carrie M., O’Connell, Jeffrey R., Oostra, Ben A., Orwoll, Eric S., Palotie, Aarno, Parker, Stephen C. J., Peacock, Munro, Perola, Markus, Peters, Annette, Polasek, Ozren, Prince, Richard L., Räikkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Robbins, John A., Rotter, Jerome I., Rudan, Igor, Salomaa, Veikko, Satterfield, Suzanne, Schadt, Eric E., Schipf, Sabine, Scott, Laura, Sehmi, Joban, Shen, Jian, Soo Shin, Chan, Sigurdsson, Gunnar, Smith, Shad, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Streeten, Elizabeth A., Styrkarsdottir, Unnur, Swart, Karin M. A., Tan, Sian-Tsung, Tarnopolsky, Mark A., Thompson, Patricia, Thomson, Cynthia A., Thorsteinsdottir, Unnur, Tikkanen, Emmi, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Verma, Arjun, Vollenweider, Peter, Völzke, Henry, Wactawski-Wende, Jean, Walker, Mark, Weedon, Michael N., Welch, Ryan, Wichmann, H.-Erich, Widen, Elisabeth, Williams, Frances M. K., Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Zhou, Yanhua, Chambers, John C., Döring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Kooner, Jaspal S., Psaty, Bruce M., Spector, Timothy D., Stefansson, Kari, Rivadeneira, Fernando, Uitterlinden, André G., Wareham, Nicholas J., Ossowski, Vicky, Waterworth, Dawn, Loos, Ruth J. F., Karasik, David, Harris, Tamara B., Ohlsson, Claes, Kiel, Douglas P. |
author_sort | zillikens, m. carola |
container_issue | 1 |
container_start_page | 0 |
container_title | Nature Communications |
container_volume | 8 |
description | <jats:title>Abstract</jats:title><jats:p>Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with <jats:italic>n</jats:italic> = 38,292) and appendicular (arms and legs) lean body mass (<jats:italic>n</jats:italic> = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (<jats:italic>p</jats:italic> < 5 × 10<jats:sup>−8</jats:sup>) or suggestively genome wide (<jats:italic>p</jats:italic> < 2.3 × 10<jats:sup>−6</jats:sup>). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near <jats:italic>HSD17B11, VCAN, ADAMTSL3</jats:italic>, <jats:italic>IRS1</jats:italic>, and <jats:italic>FTO</jats:italic> for total lean body mass and for three single-nucleotide polymorphisms in/near <jats:italic>VCAN</jats:italic>, <jats:italic>ADAMTSL3</jats:italic>, and <jats:italic>IRS1</jats:italic> for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.</jats:p> |
doi_str_mv | 10.1038/s41467-017-00031-7 |
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format_nrw | Article, E-Article |
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geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAzOC9zNDE0NjctMDE3LTAwMDMxLTc |
imprint | Springer Science and Business Media LLC, 2017 |
imprint_str_mv | Springer Science and Business Media LLC, 2017 |
institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
issn | 2041-1723 |
issn_str_mv | 2041-1723 |
language | English |
last_indexed | 2024-03-01T17:38:09.123Z |
match_str | zillikens2017largemetaanalysisofgenomewideassociationstudiesidentifiesfivelociforleanbodymass |
mega_collection | Springer Science and Business Media LLC (CrossRef) |
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publishDate | 2017 |
publishDateSort | 2017 |
publisher | Springer Science and Business Media LLC |
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recordtype | ai |
series | Nature Communications |
source_id | 49 |
spelling | Zillikens, M. Carola Demissie, Serkalem Hsu, Yi-Hsiang Yerges-Armstrong, Laura M. Chou, Wen-Chi Stolk, Lisette Livshits, Gregory Broer, Linda Johnson, Toby Koller, Daniel L. Kutalik, Zoltán Luan, Jian’an Malkin, Ida Ried, Janina S. Smith, Albert V. Thorleifsson, Gudmar Vandenput, Liesbeth Hua Zhao, Jing Zhang, Weihua Aghdassi, Ali Åkesson, Kristina Amin, Najaf Baier, Leslie J. Barroso, Inês Bennett, David A. Bertram, Lars Biffar, Rainer Bochud, Murielle Boehnke, Michael Borecki, Ingrid B. Buchman, Aron S. Byberg, Liisa Campbell, Harry Campos Obanda, Natalia Cauley, Jane A. Cawthon, Peggy M. Cederberg, Henna Chen, Zhao Cho, Nam H. Jin Choi, Hyung Claussnitzer, Melina Collins, Francis Cummings, Steven R. De Jager, Philip L. Demuth, Ilja Dhonukshe-Rutten, Rosalie A. M. Diatchenko, Luda Eiriksdottir, Gudny Enneman, Anke W. Erdos, Mike Eriksson, Johan G. Eriksson, Joel Estrada, Karol Evans, Daniel S. Feitosa, Mary F. Fu, Mao Garcia, Melissa Gieger, Christian Girke, Thomas Glazer, Nicole L. Grallert, Harald Grewal, Jagvir Han, Bok-Ghee Hanson, Robert L. Hayward, Caroline Hofman, Albert Hoffman, Eric P. Homuth, Georg Hsueh, Wen-Chi Hubal, Monica J. Hubbard, Alan Huffman, Kim M. Husted, Lise B. Illig, Thomas Ingelsson, Erik Ittermann, Till Jansson, John-Olov Jordan, Joanne M. Jula, Antti Karlsson, Magnus Khaw, Kay-Tee Kilpeläinen, Tuomas O. Klopp, Norman Kloth, Jacqueline S. L. Koistinen, Heikki A. Kraus, William E. Kritchevsky, Stephen Kuulasmaa, Teemu Kuusisto, Johanna Laakso, Markku Lahti, Jari Lang, Thomas Langdahl, Bente L. Launer, Lenore J. Lee, Jong-Young Lerch, Markus M. Lewis, Joshua R. Lind, Lars Lindgren, Cecilia Liu, Yongmei Liu, Tian Liu, Youfang Ljunggren, Östen Lorentzon, Mattias Luben, Robert N. Maixner, William McGuigan, Fiona E. Medina-Gomez, Carolina Meitinger, Thomas Melhus, Håkan Mellström, Dan Melov, Simon Michaëlsson, Karl Mitchell, Braxton D. Morris, Andrew P. Mosekilde, Leif Newman, Anne Nielson, Carrie M. O’Connell, Jeffrey R. Oostra, Ben A. Orwoll, Eric S. Palotie, Aarno Parker, Stephen C. J. Peacock, Munro Perola, Markus Peters, Annette Polasek, Ozren Prince, Richard L. Räikkönen, Katri Ralston, Stuart H. Ripatti, Samuli Robbins, John A. Rotter, Jerome I. Rudan, Igor Salomaa, Veikko Satterfield, Suzanne Schadt, Eric E. Schipf, Sabine Scott, Laura Sehmi, Joban Shen, Jian Soo Shin, Chan Sigurdsson, Gunnar Smith, Shad Soranzo, Nicole Stančáková, Alena Steinhagen-Thiessen, Elisabeth Streeten, Elizabeth A. Styrkarsdottir, Unnur Swart, Karin M. A. Tan, Sian-Tsung Tarnopolsky, Mark A. Thompson, Patricia Thomson, Cynthia A. Thorsteinsdottir, Unnur Tikkanen, Emmi Tranah, Gregory J. Tuomilehto, Jaakko van Schoor, Natasja M. Verma, Arjun Vollenweider, Peter Völzke, Henry Wactawski-Wende, Jean Walker, Mark Weedon, Michael N. Welch, Ryan Wichmann, H.-Erich Widen, Elisabeth Williams, Frances M. K. Wilson, James F. Wright, Nicole C. Xie, Weijia Yu, Lei Zhou, Yanhua Chambers, John C. Döring, Angela van Duijn, Cornelia M. Econs, Michael J. Gudnason, Vilmundur Kooner, Jaspal S. Psaty, Bruce M. Spector, Timothy D. Stefansson, Kari Rivadeneira, Fernando Uitterlinden, André G. Wareham, Nicholas J. Ossowski, Vicky Waterworth, Dawn Loos, Ruth J. F. Karasik, David Harris, Tamara B. Ohlsson, Claes Kiel, Douglas P. 2041-1723 Springer Science and Business Media LLC General Physics and Astronomy General Biochemistry, Genetics and Molecular Biology General Chemistry Multidisciplinary http://dx.doi.org/10.1038/s41467-017-00031-7 <jats:title>Abstract</jats:title><jats:p>Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with <jats:italic>n</jats:italic> = 38,292) and appendicular (arms and legs) lean body mass (<jats:italic>n</jats:italic> = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (<jats:italic>p</jats:italic> < 5 × 10<jats:sup>−8</jats:sup>) or suggestively genome wide (<jats:italic>p</jats:italic> < 2.3 × 10<jats:sup>−6</jats:sup>). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near <jats:italic>HSD17B11, VCAN, ADAMTSL3</jats:italic>, <jats:italic>IRS1</jats:italic>, and <jats:italic>FTO</jats:italic> for total lean body mass and for three single-nucleotide polymorphisms in/near <jats:italic>VCAN</jats:italic>, <jats:italic>ADAMTSL3</jats:italic>, and <jats:italic>IRS1</jats:italic> for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.</jats:p> Large meta-analysis of genome-wide association studies identifies five loci for lean body mass Nature Communications |
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title | Large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
title_full | Large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
title_fullStr | Large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
title_full_unstemmed | Large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
title_short | Large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
title_sort | large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
title_unstemmed | Large meta-analysis of genome-wide association studies identifies five loci for lean body mass |
topic | General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary |
url | http://dx.doi.org/10.1038/s41467-017-00031-7 |