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A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive

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Bibliographische Detailangaben
Zeitschriftentitel: Journal of Neurophysiology
Personen und Körperschaften: Zhou, Yi, Colburn, H. Steven
In: Journal of Neurophysiology, 103, 2010, 5, S. 2355-2371
Medientyp: E-Article
Sprache: Englisch
veröffentlicht:
American Physiological Society
Schlagwörter:
author_facet Zhou, Yi
Colburn, H. Steven
Zhou, Yi
Colburn, H. Steven
author Zhou, Yi
Colburn, H. Steven
spellingShingle Zhou, Yi
Colburn, H. Steven
Journal of Neurophysiology
A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
Physiology
General Neuroscience
author_sort zhou, yi
spelling Zhou, Yi Colburn, H. Steven 0022-3077 1522-1598 American Physiological Society Physiology General Neuroscience http://dx.doi.org/10.1152/jn.00385.2009 <jats:p> The lateral superior olive (LSO) is the first nucleus in the ascending auditory pathway that encodes acoustic level information from both ears, the interaural level difference (ILD). This sensitivity is believed to result from the relative strengths of ipsilateral excitation and contralateral inhibition. The study reported here simulated sound-evoked responses of LSO chopper units with a focus on the role of the heterogeneity in membrane afterhyperpolarization (AHP) channels on spike interval statistics and on ILD encoding. A relatively simplified cell model was used so that the effects of interest could be isolated. Specifically, the amplitude and time constant of the AHP conductance within a leaky integrate-and-fire (LIF) cell model were studied. This extends the work of others who used a more physiologically detailed model. Results show that differences in these two parameters lead to both the distinctive chopper response patterns and to the level-dependent interval statistics as observed in vivo. In general, diverse AHP characteristics enable an enhanced contrast across population responses with respect to rate gain and temporal correlations. This membrane heterogeneity provides an internal, cell-specific dimension for the neural representation of stimulus information, allowing sensitivity to ILDs of dynamic stimuli. </jats:p> A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive Journal of Neurophysiology
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title A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
title_unstemmed A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
title_full A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
title_fullStr A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
title_full_unstemmed A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
title_short A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
title_sort a modeling study of the effects of membrane afterhyperpolarization on spike interval statistics and on ild encoding in the lateral superior olive
topic Physiology
General Neuroscience
url http://dx.doi.org/10.1152/jn.00385.2009
publishDate 2010
physical 2355-2371
description <jats:p> The lateral superior olive (LSO) is the first nucleus in the ascending auditory pathway that encodes acoustic level information from both ears, the interaural level difference (ILD). This sensitivity is believed to result from the relative strengths of ipsilateral excitation and contralateral inhibition. The study reported here simulated sound-evoked responses of LSO chopper units with a focus on the role of the heterogeneity in membrane afterhyperpolarization (AHP) channels on spike interval statistics and on ILD encoding. A relatively simplified cell model was used so that the effects of interest could be isolated. Specifically, the amplitude and time constant of the AHP conductance within a leaky integrate-and-fire (LIF) cell model were studied. This extends the work of others who used a more physiologically detailed model. Results show that differences in these two parameters lead to both the distinctive chopper response patterns and to the level-dependent interval statistics as observed in vivo. In general, diverse AHP characteristics enable an enhanced contrast across population responses with respect to rate gain and temporal correlations. This membrane heterogeneity provides an internal, cell-specific dimension for the neural representation of stimulus information, allowing sensitivity to ILDs of dynamic stimuli. </jats:p>
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author Zhou, Yi, Colburn, H. Steven
author_facet Zhou, Yi, Colburn, H. Steven, Zhou, Yi, Colburn, H. Steven
author_sort zhou, yi
container_issue 5
container_start_page 2355
container_title Journal of Neurophysiology
container_volume 103
description <jats:p> The lateral superior olive (LSO) is the first nucleus in the ascending auditory pathway that encodes acoustic level information from both ears, the interaural level difference (ILD). This sensitivity is believed to result from the relative strengths of ipsilateral excitation and contralateral inhibition. The study reported here simulated sound-evoked responses of LSO chopper units with a focus on the role of the heterogeneity in membrane afterhyperpolarization (AHP) channels on spike interval statistics and on ILD encoding. A relatively simplified cell model was used so that the effects of interest could be isolated. Specifically, the amplitude and time constant of the AHP conductance within a leaky integrate-and-fire (LIF) cell model were studied. This extends the work of others who used a more physiologically detailed model. Results show that differences in these two parameters lead to both the distinctive chopper response patterns and to the level-dependent interval statistics as observed in vivo. In general, diverse AHP characteristics enable an enhanced contrast across population responses with respect to rate gain and temporal correlations. This membrane heterogeneity provides an internal, cell-specific dimension for the neural representation of stimulus information, allowing sensitivity to ILDs of dynamic stimuli. </jats:p>
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spelling Zhou, Yi Colburn, H. Steven 0022-3077 1522-1598 American Physiological Society Physiology General Neuroscience http://dx.doi.org/10.1152/jn.00385.2009 <jats:p> The lateral superior olive (LSO) is the first nucleus in the ascending auditory pathway that encodes acoustic level information from both ears, the interaural level difference (ILD). This sensitivity is believed to result from the relative strengths of ipsilateral excitation and contralateral inhibition. The study reported here simulated sound-evoked responses of LSO chopper units with a focus on the role of the heterogeneity in membrane afterhyperpolarization (AHP) channels on spike interval statistics and on ILD encoding. A relatively simplified cell model was used so that the effects of interest could be isolated. Specifically, the amplitude and time constant of the AHP conductance within a leaky integrate-and-fire (LIF) cell model were studied. This extends the work of others who used a more physiologically detailed model. Results show that differences in these two parameters lead to both the distinctive chopper response patterns and to the level-dependent interval statistics as observed in vivo. In general, diverse AHP characteristics enable an enhanced contrast across population responses with respect to rate gain and temporal correlations. This membrane heterogeneity provides an internal, cell-specific dimension for the neural representation of stimulus information, allowing sensitivity to ILDs of dynamic stimuli. </jats:p> A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive Journal of Neurophysiology
spellingShingle Zhou, Yi, Colburn, H. Steven, Journal of Neurophysiology, A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive, Physiology, General Neuroscience
title A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
title_full A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
title_fullStr A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
title_full_unstemmed A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
title_short A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
title_sort a modeling study of the effects of membrane afterhyperpolarization on spike interval statistics and on ild encoding in the lateral superior olive
title_unstemmed A Modeling Study of the Effects of Membrane Afterhyperpolarization on Spike Interval Statistics and on ILD Encoding in the Lateral Superior Olive
topic Physiology, General Neuroscience
url http://dx.doi.org/10.1152/jn.00385.2009