Eintrag weiter verarbeiten
Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases
Gespeichert in:
Zeitschriftentitel: | Cancer Research |
---|---|
Personen und Körperschaften: | , , |
In: | Cancer Research, 70, 2010, 2, S. 646-654 |
Medientyp: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
American Association for Cancer Research (AACR)
|
Schlagwörter: |
author_facet |
Li, Yongming Li, Xia Guo, Bin Li, Yongming Li, Xia Guo, Bin |
---|---|
author |
Li, Yongming Li, Xia Guo, Bin |
spellingShingle |
Li, Yongming Li, Xia Guo, Bin Cancer Research Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases Cancer Research Oncology |
author_sort |
li, yongming |
spelling |
Li, Yongming Li, Xia Guo, Bin 0008-5472 1538-7445 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/0008-5472.can-09-1924 <jats:title>Abstract</jats:title> <jats:p>3,3′-Diindolylmethane (DIM) is an anticancer agent that induces cell cycle arrest and apoptosis through unknown mechanisms. Here, we report that DIM can selectively induce proteasome-mediated degradation of class I histone deacetylases (HDAC1, HDAC2, HDAC3, and HDAC8) without affecting the class II HDAC proteins. DIM induced downregulation of class I HDACs in human colon cancer cells in vitro and in vivo in tumor xenografts. HDAC depletion relieved HDAC-mediated transcriptional inhibition of the cyclin-dependent kinase inhibitors p21WAF1 and p27KIP2, significantly increasing their expression and triggering cell cycle arrest in the G2 phase of the cell cycle. Additionally, HDAC depletion was associated with an induction of DNA damage that triggered apoptosis. Our findings indicate that DIM acts to selectively target the degradation of class I HDACs. Cancer Res; 70(2); 646–54</jats:p> Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases Cancer Research |
doi_str_mv |
10.1158/0008-5472.can-09-1924 |
facet_avail |
Online Free |
finc_class_facet |
Medizin |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8wMDA4LTU0NzIuY2FuLTA5LTE5MjQ |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8wMDA4LTU0NzIuY2FuLTA5LTE5MjQ |
institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
imprint |
American Association for Cancer Research (AACR), 2010 |
imprint_str_mv |
American Association for Cancer Research (AACR), 2010 |
issn |
0008-5472 1538-7445 |
issn_str_mv |
0008-5472 1538-7445 |
language |
English |
mega_collection |
American Association for Cancer Research (AACR) (CrossRef) |
match_str |
li2010chemopreventiveagent33diindolylmethaneselectivelyinducesproteasomaldegradationofclassihistonedeacetylases |
publishDateSort |
2010 |
publisher |
American Association for Cancer Research (AACR) |
recordtype |
ai |
record_format |
ai |
series |
Cancer Research |
source_id |
49 |
title |
Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases |
title_unstemmed |
Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases |
title_full |
Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases |
title_fullStr |
Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases |
title_full_unstemmed |
Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases |
title_short |
Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases |
title_sort |
chemopreventive agent 3,3′-diindolylmethane selectively induces proteasomal degradation of class i histone deacetylases |
topic |
Cancer Research Oncology |
url |
http://dx.doi.org/10.1158/0008-5472.can-09-1924 |
publishDate |
2010 |
physical |
646-654 |
description |
<jats:title>Abstract</jats:title>
<jats:p>3,3′-Diindolylmethane (DIM) is an anticancer agent that induces cell cycle arrest and apoptosis through unknown mechanisms. Here, we report that DIM can selectively induce proteasome-mediated degradation of class I histone deacetylases (HDAC1, HDAC2, HDAC3, and HDAC8) without affecting the class II HDAC proteins. DIM induced downregulation of class I HDACs in human colon cancer cells in vitro and in vivo in tumor xenografts. HDAC depletion relieved HDAC-mediated transcriptional inhibition of the cyclin-dependent kinase inhibitors p21WAF1 and p27KIP2, significantly increasing their expression and triggering cell cycle arrest in the G2 phase of the cell cycle. Additionally, HDAC depletion was associated with an induction of DNA damage that triggered apoptosis. Our findings indicate that DIM acts to selectively target the degradation of class I HDACs. Cancer Res; 70(2); 646–54</jats:p> |
container_issue |
2 |
container_start_page |
646 |
container_title |
Cancer Research |
container_volume |
70 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792347730525290498 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T17:59:55.944Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Chemopreventive+Agent+3%2C3%E2%80%B2-Diindolylmethane+Selectively+Induces+Proteasomal+Degradation+of+Class+I+Histone+Deacetylases&rft.date=2010-01-15&genre=article&issn=1538-7445&volume=70&issue=2&spage=646&epage=654&pages=646-654&jtitle=Cancer+Research&atitle=Chemopreventive+Agent+3%2C3%E2%80%B2-Diindolylmethane+Selectively+Induces+Proteasomal+Degradation+of+Class+I+Histone+Deacetylases&aulast=Guo&aufirst=Bin&rft_id=info%3Adoi%2F10.1158%2F0008-5472.can-09-1924&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792347730525290498 |
author | Li, Yongming, Li, Xia, Guo, Bin |
author_facet | Li, Yongming, Li, Xia, Guo, Bin, Li, Yongming, Li, Xia, Guo, Bin |
author_sort | li, yongming |
container_issue | 2 |
container_start_page | 646 |
container_title | Cancer Research |
container_volume | 70 |
description | <jats:title>Abstract</jats:title> <jats:p>3,3′-Diindolylmethane (DIM) is an anticancer agent that induces cell cycle arrest and apoptosis through unknown mechanisms. Here, we report that DIM can selectively induce proteasome-mediated degradation of class I histone deacetylases (HDAC1, HDAC2, HDAC3, and HDAC8) without affecting the class II HDAC proteins. DIM induced downregulation of class I HDACs in human colon cancer cells in vitro and in vivo in tumor xenografts. HDAC depletion relieved HDAC-mediated transcriptional inhibition of the cyclin-dependent kinase inhibitors p21WAF1 and p27KIP2, significantly increasing their expression and triggering cell cycle arrest in the G2 phase of the cell cycle. Additionally, HDAC depletion was associated with an induction of DNA damage that triggered apoptosis. Our findings indicate that DIM acts to selectively target the degradation of class I HDACs. Cancer Res; 70(2); 646–54</jats:p> |
doi_str_mv | 10.1158/0008-5472.can-09-1924 |
facet_avail | Online, Free |
finc_class_facet | Medizin |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE1OC8wMDA4LTU0NzIuY2FuLTA5LTE5MjQ |
imprint | American Association for Cancer Research (AACR), 2010 |
imprint_str_mv | American Association for Cancer Research (AACR), 2010 |
institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
issn | 0008-5472, 1538-7445 |
issn_str_mv | 0008-5472, 1538-7445 |
language | English |
last_indexed | 2024-03-01T17:59:55.944Z |
match_str | li2010chemopreventiveagent33diindolylmethaneselectivelyinducesproteasomaldegradationofclassihistonedeacetylases |
mega_collection | American Association for Cancer Research (AACR) (CrossRef) |
physical | 646-654 |
publishDate | 2010 |
publishDateSort | 2010 |
publisher | American Association for Cancer Research (AACR) |
record_format | ai |
recordtype | ai |
series | Cancer Research |
source_id | 49 |
spelling | Li, Yongming Li, Xia Guo, Bin 0008-5472 1538-7445 American Association for Cancer Research (AACR) Cancer Research Oncology http://dx.doi.org/10.1158/0008-5472.can-09-1924 <jats:title>Abstract</jats:title> <jats:p>3,3′-Diindolylmethane (DIM) is an anticancer agent that induces cell cycle arrest and apoptosis through unknown mechanisms. Here, we report that DIM can selectively induce proteasome-mediated degradation of class I histone deacetylases (HDAC1, HDAC2, HDAC3, and HDAC8) without affecting the class II HDAC proteins. DIM induced downregulation of class I HDACs in human colon cancer cells in vitro and in vivo in tumor xenografts. HDAC depletion relieved HDAC-mediated transcriptional inhibition of the cyclin-dependent kinase inhibitors p21WAF1 and p27KIP2, significantly increasing their expression and triggering cell cycle arrest in the G2 phase of the cell cycle. Additionally, HDAC depletion was associated with an induction of DNA damage that triggered apoptosis. Our findings indicate that DIM acts to selectively target the degradation of class I HDACs. Cancer Res; 70(2); 646–54</jats:p> Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases Cancer Research |
spellingShingle | Li, Yongming, Li, Xia, Guo, Bin, Cancer Research, Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases, Cancer Research, Oncology |
title | Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases |
title_full | Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases |
title_fullStr | Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases |
title_full_unstemmed | Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases |
title_short | Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases |
title_sort | chemopreventive agent 3,3′-diindolylmethane selectively induces proteasomal degradation of class i histone deacetylases |
title_unstemmed | Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases |
topic | Cancer Research, Oncology |
url | http://dx.doi.org/10.1158/0008-5472.can-09-1924 |