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Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial

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Zeitschriftentitel: Psychotherapy and Psychosomatics
Personen und Körperschaften: Klein, Jan Philipp, Berger, Thomas, Schröder, Johanna, Späth, Christina, Meyer, Björn, Caspar, Franz, Lutz, Wolfgang, Arndt, Alice, Greiner, Wolfgang, Gräfe, Viola, Hautzinger, Martin, Fuhr, Kristina, Rose, Matthias, Nolte, Sandra, Löwe, Bernd, Andersson, Gerhard, Vettorazzi, Eik, Moritz, Steffen, Hohagen, Fritz
In: Psychotherapy and Psychosomatics, 85, 2016, 4, S. 218-228
Medientyp: E-Article
Sprache: Englisch
veröffentlicht:
S. Karger AG
Schlagwörter:
author_facet Klein, Jan Philipp
Berger, Thomas
Schröder, Johanna
Späth, Christina
Meyer, Björn
Caspar, Franz
Lutz, Wolfgang
Arndt, Alice
Greiner, Wolfgang
Gräfe, Viola
Hautzinger, Martin
Fuhr, Kristina
Rose, Matthias
Nolte, Sandra
Löwe, Bernd
Andersson, Gerhard
Vettorazzi, Eik
Moritz, Steffen
Hohagen, Fritz
Klein, Jan Philipp
Berger, Thomas
Schröder, Johanna
Späth, Christina
Meyer, Björn
Caspar, Franz
Lutz, Wolfgang
Arndt, Alice
Greiner, Wolfgang
Gräfe, Viola
Hautzinger, Martin
Fuhr, Kristina
Rose, Matthias
Nolte, Sandra
Löwe, Bernd
Andersson, Gerhard
Vettorazzi, Eik
Moritz, Steffen
Hohagen, Fritz
author Klein, Jan Philipp
Berger, Thomas
Schröder, Johanna
Späth, Christina
Meyer, Björn
Caspar, Franz
Lutz, Wolfgang
Arndt, Alice
Greiner, Wolfgang
Gräfe, Viola
Hautzinger, Martin
Fuhr, Kristina
Rose, Matthias
Nolte, Sandra
Löwe, Bernd
Andersson, Gerhard
Vettorazzi, Eik
Moritz, Steffen
Hohagen, Fritz
spellingShingle Klein, Jan Philipp
Berger, Thomas
Schröder, Johanna
Späth, Christina
Meyer, Björn
Caspar, Franz
Lutz, Wolfgang
Arndt, Alice
Greiner, Wolfgang
Gräfe, Viola
Hautzinger, Martin
Fuhr, Kristina
Rose, Matthias
Nolte, Sandra
Löwe, Bernd
Andersson, Gerhard
Vettorazzi, Eik
Moritz, Steffen
Hohagen, Fritz
Psychotherapy and Psychosomatics
Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
Psychiatry and Mental health
Applied Psychology
Clinical Psychology
General Medicine
author_sort klein, jan philipp
spelling Klein, Jan Philipp Berger, Thomas Schröder, Johanna Späth, Christina Meyer, Björn Caspar, Franz Lutz, Wolfgang Arndt, Alice Greiner, Wolfgang Gräfe, Viola Hautzinger, Martin Fuhr, Kristina Rose, Matthias Nolte, Sandra Löwe, Bernd Andersson, Gerhard Vettorazzi, Eik Moritz, Steffen Hohagen, Fritz 0033-3190 1423-0348 S. Karger AG Psychiatry and Mental health Applied Psychology Clinical Psychology General Medicine http://dx.doi.org/10.1159/000445355 <jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Mild to moderate depressive symptoms are common but often remain unrecognized and treated inadequately. We hypothesized that an Internet intervention in addition to usual care is superior to care as usual alone (CAU) in the treatment of mild to moderate depressive symptoms in adults. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; This trial was controlled, randomized and assessor-blinded. Participants with mild to moderate depressive symptoms (Patient Health Questionnaire, PHQ-9, score 5-14) were recruited from clinical and non-clinical settings and randomized to either CAU or a 12-week Internet intervention (Deprexis) adjunctive to usual care. Outcomes were assessed at baseline, 3 months (post-assessment) and 6 months (follow-up). The primary outcome measure was self-rated depression severity (PHQ-9). The main analysis was based on the intention-to-treat principle and used linear mixed models. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; A total of 1,013 participants were randomized. Changes in PHQ-9 from baseline differed signi&amp;#xFB01;cantly between groups (t&lt;sub&gt;825&lt;/sub&gt; = 6.12, p &lt; 0.001 for the main effect of group). The post-assessment between-group effect size in favour of the intervention was &lt;i&gt;d&lt;/i&gt; = 0.39 (95% CI: 0.13-0.64). It was stable at follow-up, with &lt;i&gt;d&lt;/i&gt; = 0.32 (95% CI: 0.06-0.69). The rate of participants experiencing at least minimally clinically important PHQ-9 change at the post-assessment was higher in the intervention group (35.6 vs. 20.2%) with a number needed to treat of 7 (95% CI: 5-10). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; The Internet intervention examined in this trial was superior to CAU alone in reducing mild to moderate depressive symptoms. The magnitude of the effect is clinically important and has public health implications.</jats:p> Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial Psychotherapy and Psychosomatics
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title Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
title_unstemmed Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
title_full Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
title_fullStr Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
title_full_unstemmed Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
title_short Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
title_sort effects of a psychological internet intervention in the treatment of mild to moderate depressive symptoms: results of the evident study, a randomized controlled trial
topic Psychiatry and Mental health
Applied Psychology
Clinical Psychology
General Medicine
url http://dx.doi.org/10.1159/000445355
publishDate 2016
physical 218-228
description <jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Mild to moderate depressive symptoms are common but often remain unrecognized and treated inadequately. We hypothesized that an Internet intervention in addition to usual care is superior to care as usual alone (CAU) in the treatment of mild to moderate depressive symptoms in adults. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; This trial was controlled, randomized and assessor-blinded. Participants with mild to moderate depressive symptoms (Patient Health Questionnaire, PHQ-9, score 5-14) were recruited from clinical and non-clinical settings and randomized to either CAU or a 12-week Internet intervention (Deprexis) adjunctive to usual care. Outcomes were assessed at baseline, 3 months (post-assessment) and 6 months (follow-up). The primary outcome measure was self-rated depression severity (PHQ-9). The main analysis was based on the intention-to-treat principle and used linear mixed models. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; A total of 1,013 participants were randomized. Changes in PHQ-9 from baseline differed signi&amp;#xFB01;cantly between groups (t&lt;sub&gt;825&lt;/sub&gt; = 6.12, p &lt; 0.001 for the main effect of group). The post-assessment between-group effect size in favour of the intervention was &lt;i&gt;d&lt;/i&gt; = 0.39 (95% CI: 0.13-0.64). It was stable at follow-up, with &lt;i&gt;d&lt;/i&gt; = 0.32 (95% CI: 0.06-0.69). The rate of participants experiencing at least minimally clinically important PHQ-9 change at the post-assessment was higher in the intervention group (35.6 vs. 20.2%) with a number needed to treat of 7 (95% CI: 5-10). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; The Internet intervention examined in this trial was superior to CAU alone in reducing mild to moderate depressive symptoms. The magnitude of the effect is clinically important and has public health implications.</jats:p>
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author Klein, Jan Philipp, Berger, Thomas, Schröder, Johanna, Späth, Christina, Meyer, Björn, Caspar, Franz, Lutz, Wolfgang, Arndt, Alice, Greiner, Wolfgang, Gräfe, Viola, Hautzinger, Martin, Fuhr, Kristina, Rose, Matthias, Nolte, Sandra, Löwe, Bernd, Andersson, Gerhard, Vettorazzi, Eik, Moritz, Steffen, Hohagen, Fritz
author_facet Klein, Jan Philipp, Berger, Thomas, Schröder, Johanna, Späth, Christina, Meyer, Björn, Caspar, Franz, Lutz, Wolfgang, Arndt, Alice, Greiner, Wolfgang, Gräfe, Viola, Hautzinger, Martin, Fuhr, Kristina, Rose, Matthias, Nolte, Sandra, Löwe, Bernd, Andersson, Gerhard, Vettorazzi, Eik, Moritz, Steffen, Hohagen, Fritz, Klein, Jan Philipp, Berger, Thomas, Schröder, Johanna, Späth, Christina, Meyer, Björn, Caspar, Franz, Lutz, Wolfgang, Arndt, Alice, Greiner, Wolfgang, Gräfe, Viola, Hautzinger, Martin, Fuhr, Kristina, Rose, Matthias, Nolte, Sandra, Löwe, Bernd, Andersson, Gerhard, Vettorazzi, Eik, Moritz, Steffen, Hohagen, Fritz
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description <jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Mild to moderate depressive symptoms are common but often remain unrecognized and treated inadequately. We hypothesized that an Internet intervention in addition to usual care is superior to care as usual alone (CAU) in the treatment of mild to moderate depressive symptoms in adults. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; This trial was controlled, randomized and assessor-blinded. Participants with mild to moderate depressive symptoms (Patient Health Questionnaire, PHQ-9, score 5-14) were recruited from clinical and non-clinical settings and randomized to either CAU or a 12-week Internet intervention (Deprexis) adjunctive to usual care. Outcomes were assessed at baseline, 3 months (post-assessment) and 6 months (follow-up). The primary outcome measure was self-rated depression severity (PHQ-9). The main analysis was based on the intention-to-treat principle and used linear mixed models. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; A total of 1,013 participants were randomized. Changes in PHQ-9 from baseline differed signi&amp;#xFB01;cantly between groups (t&lt;sub&gt;825&lt;/sub&gt; = 6.12, p &lt; 0.001 for the main effect of group). The post-assessment between-group effect size in favour of the intervention was &lt;i&gt;d&lt;/i&gt; = 0.39 (95% CI: 0.13-0.64). It was stable at follow-up, with &lt;i&gt;d&lt;/i&gt; = 0.32 (95% CI: 0.06-0.69). The rate of participants experiencing at least minimally clinically important PHQ-9 change at the post-assessment was higher in the intervention group (35.6 vs. 20.2%) with a number needed to treat of 7 (95% CI: 5-10). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; The Internet intervention examined in this trial was superior to CAU alone in reducing mild to moderate depressive symptoms. The magnitude of the effect is clinically important and has public health implications.</jats:p>
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spelling Klein, Jan Philipp Berger, Thomas Schröder, Johanna Späth, Christina Meyer, Björn Caspar, Franz Lutz, Wolfgang Arndt, Alice Greiner, Wolfgang Gräfe, Viola Hautzinger, Martin Fuhr, Kristina Rose, Matthias Nolte, Sandra Löwe, Bernd Andersson, Gerhard Vettorazzi, Eik Moritz, Steffen Hohagen, Fritz 0033-3190 1423-0348 S. Karger AG Psychiatry and Mental health Applied Psychology Clinical Psychology General Medicine http://dx.doi.org/10.1159/000445355 <jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Mild to moderate depressive symptoms are common but often remain unrecognized and treated inadequately. We hypothesized that an Internet intervention in addition to usual care is superior to care as usual alone (CAU) in the treatment of mild to moderate depressive symptoms in adults. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; This trial was controlled, randomized and assessor-blinded. Participants with mild to moderate depressive symptoms (Patient Health Questionnaire, PHQ-9, score 5-14) were recruited from clinical and non-clinical settings and randomized to either CAU or a 12-week Internet intervention (Deprexis) adjunctive to usual care. Outcomes were assessed at baseline, 3 months (post-assessment) and 6 months (follow-up). The primary outcome measure was self-rated depression severity (PHQ-9). The main analysis was based on the intention-to-treat principle and used linear mixed models. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; A total of 1,013 participants were randomized. Changes in PHQ-9 from baseline differed signi&amp;#xFB01;cantly between groups (t&lt;sub&gt;825&lt;/sub&gt; = 6.12, p &lt; 0.001 for the main effect of group). The post-assessment between-group effect size in favour of the intervention was &lt;i&gt;d&lt;/i&gt; = 0.39 (95% CI: 0.13-0.64). It was stable at follow-up, with &lt;i&gt;d&lt;/i&gt; = 0.32 (95% CI: 0.06-0.69). The rate of participants experiencing at least minimally clinically important PHQ-9 change at the post-assessment was higher in the intervention group (35.6 vs. 20.2%) with a number needed to treat of 7 (95% CI: 5-10). &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; The Internet intervention examined in this trial was superior to CAU alone in reducing mild to moderate depressive symptoms. The magnitude of the effect is clinically important and has public health implications.</jats:p> Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial Psychotherapy and Psychosomatics
spellingShingle Klein, Jan Philipp, Berger, Thomas, Schröder, Johanna, Späth, Christina, Meyer, Björn, Caspar, Franz, Lutz, Wolfgang, Arndt, Alice, Greiner, Wolfgang, Gräfe, Viola, Hautzinger, Martin, Fuhr, Kristina, Rose, Matthias, Nolte, Sandra, Löwe, Bernd, Andersson, Gerhard, Vettorazzi, Eik, Moritz, Steffen, Hohagen, Fritz, Psychotherapy and Psychosomatics, Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial, Psychiatry and Mental health, Applied Psychology, Clinical Psychology, General Medicine
title Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
title_full Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
title_fullStr Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
title_full_unstemmed Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
title_short Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
title_sort effects of a psychological internet intervention in the treatment of mild to moderate depressive symptoms: results of the evident study, a randomized controlled trial
title_unstemmed Effects of a Psychological Internet Intervention in the Treatment of Mild to Moderate Depressive Symptoms: Results of the EVIDENT Study, a Randomized Controlled Trial
topic Psychiatry and Mental health, Applied Psychology, Clinical Psychology, General Medicine
url http://dx.doi.org/10.1159/000445355