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Chemotherapy in Elderly Patients with Gynecological Cancer

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Bibliographische Detailangaben
Zeitschriftentitel: Oncology
Personen und Körperschaften: Palaia, Innocenza, Loprete, Elisa, Musella, Angela, Marchetti, Claudia, Di Donato, Violante, Bellati, Filippo, Benedetti Panici, Pierluigi
In: Oncology, 85, 2013, 3, S. 168-172
Medientyp: E-Article
Sprache: Englisch
veröffentlicht:
S. Karger AG
Schlagwörter:
author_facet Palaia, Innocenza
Loprete, Elisa
Musella, Angela
Marchetti, Claudia
Di Donato, Violante
Bellati, Filippo
Benedetti Panici, Pierluigi
Palaia, Innocenza
Loprete, Elisa
Musella, Angela
Marchetti, Claudia
Di Donato, Violante
Bellati, Filippo
Benedetti Panici, Pierluigi
author Palaia, Innocenza
Loprete, Elisa
Musella, Angela
Marchetti, Claudia
Di Donato, Violante
Bellati, Filippo
Benedetti Panici, Pierluigi
spellingShingle Palaia, Innocenza
Loprete, Elisa
Musella, Angela
Marchetti, Claudia
Di Donato, Violante
Bellati, Filippo
Benedetti Panici, Pierluigi
Oncology
Chemotherapy in Elderly Patients with Gynecological Cancer
Cancer Research
Oncology
General Medicine
author_sort palaia, innocenza
spelling Palaia, Innocenza Loprete, Elisa Musella, Angela Marchetti, Claudia Di Donato, Violante Bellati, Filippo Benedetti Panici, Pierluigi 0030-2414 1423-0232 S. Karger AG Cancer Research Oncology General Medicine http://dx.doi.org/10.1159/000350859 <jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; The aim of this study was to determine the tolerability, safety and feasibility of chemotherapy in very elderly patients with gynecological cancers. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We included all patients ≥75 years of age affected by endometrial, ovarian or cervical cancer treated with neoadjuvant, adjuvant or palliative chemotherapy. Data regarding age, stage of the disease, comorbidities, performance status (PS), chemotherapy regimen and dosing, toxicity, treatment delay and dose adjustments were recorded. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Forty-nine patients were included in the study. Their median age was 77.5 years. The vast majority of patients (89.8%) presented with advanced neoplastic disease. Twenty-nine of the 49 patients were treated with full-dose chemotherapy; 41% were subjected to the weekly dose. One toxic death was recorded; grade 2 anemia was reported in 8 patients, and grade 2 and 3 neutropenia was recorded in 2 and 3 patients, respectively. Sixty-one percent of the patients completed the planned treatment. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Chemotherapy in very elderly patients is feasible with an acceptable toxicity profile. Careful evaluation of PS and assessment of physical and psychological health are necessary to predict tolerability of chemotherapy. A weekly schedule is better tolerated in this setting.</jats:p> Chemotherapy in Elderly Patients with Gynecological Cancer Oncology
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title Chemotherapy in Elderly Patients with Gynecological Cancer
title_unstemmed Chemotherapy in Elderly Patients with Gynecological Cancer
title_full Chemotherapy in Elderly Patients with Gynecological Cancer
title_fullStr Chemotherapy in Elderly Patients with Gynecological Cancer
title_full_unstemmed Chemotherapy in Elderly Patients with Gynecological Cancer
title_short Chemotherapy in Elderly Patients with Gynecological Cancer
title_sort chemotherapy in elderly patients with gynecological cancer
topic Cancer Research
Oncology
General Medicine
url http://dx.doi.org/10.1159/000350859
publishDate 2013
physical 168-172
description <jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; The aim of this study was to determine the tolerability, safety and feasibility of chemotherapy in very elderly patients with gynecological cancers. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We included all patients ≥75 years of age affected by endometrial, ovarian or cervical cancer treated with neoadjuvant, adjuvant or palliative chemotherapy. Data regarding age, stage of the disease, comorbidities, performance status (PS), chemotherapy regimen and dosing, toxicity, treatment delay and dose adjustments were recorded. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Forty-nine patients were included in the study. Their median age was 77.5 years. The vast majority of patients (89.8%) presented with advanced neoplastic disease. Twenty-nine of the 49 patients were treated with full-dose chemotherapy; 41% were subjected to the weekly dose. One toxic death was recorded; grade 2 anemia was reported in 8 patients, and grade 2 and 3 neutropenia was recorded in 2 and 3 patients, respectively. Sixty-one percent of the patients completed the planned treatment. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Chemotherapy in very elderly patients is feasible with an acceptable toxicity profile. Careful evaluation of PS and assessment of physical and psychological health are necessary to predict tolerability of chemotherapy. A weekly schedule is better tolerated in this setting.</jats:p>
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author Palaia, Innocenza, Loprete, Elisa, Musella, Angela, Marchetti, Claudia, Di Donato, Violante, Bellati, Filippo, Benedetti Panici, Pierluigi
author_facet Palaia, Innocenza, Loprete, Elisa, Musella, Angela, Marchetti, Claudia, Di Donato, Violante, Bellati, Filippo, Benedetti Panici, Pierluigi, Palaia, Innocenza, Loprete, Elisa, Musella, Angela, Marchetti, Claudia, Di Donato, Violante, Bellati, Filippo, Benedetti Panici, Pierluigi
author_sort palaia, innocenza
container_issue 3
container_start_page 168
container_title Oncology
container_volume 85
description <jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; The aim of this study was to determine the tolerability, safety and feasibility of chemotherapy in very elderly patients with gynecological cancers. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We included all patients ≥75 years of age affected by endometrial, ovarian or cervical cancer treated with neoadjuvant, adjuvant or palliative chemotherapy. Data regarding age, stage of the disease, comorbidities, performance status (PS), chemotherapy regimen and dosing, toxicity, treatment delay and dose adjustments were recorded. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Forty-nine patients were included in the study. Their median age was 77.5 years. The vast majority of patients (89.8%) presented with advanced neoplastic disease. Twenty-nine of the 49 patients were treated with full-dose chemotherapy; 41% were subjected to the weekly dose. One toxic death was recorded; grade 2 anemia was reported in 8 patients, and grade 2 and 3 neutropenia was recorded in 2 and 3 patients, respectively. Sixty-one percent of the patients completed the planned treatment. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Chemotherapy in very elderly patients is feasible with an acceptable toxicity profile. Careful evaluation of PS and assessment of physical and psychological health are necessary to predict tolerability of chemotherapy. A weekly schedule is better tolerated in this setting.</jats:p>
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spelling Palaia, Innocenza Loprete, Elisa Musella, Angela Marchetti, Claudia Di Donato, Violante Bellati, Filippo Benedetti Panici, Pierluigi 0030-2414 1423-0232 S. Karger AG Cancer Research Oncology General Medicine http://dx.doi.org/10.1159/000350859 <jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; The aim of this study was to determine the tolerability, safety and feasibility of chemotherapy in very elderly patients with gynecological cancers. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We included all patients ≥75 years of age affected by endometrial, ovarian or cervical cancer treated with neoadjuvant, adjuvant or palliative chemotherapy. Data regarding age, stage of the disease, comorbidities, performance status (PS), chemotherapy regimen and dosing, toxicity, treatment delay and dose adjustments were recorded. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Forty-nine patients were included in the study. Their median age was 77.5 years. The vast majority of patients (89.8%) presented with advanced neoplastic disease. Twenty-nine of the 49 patients were treated with full-dose chemotherapy; 41% were subjected to the weekly dose. One toxic death was recorded; grade 2 anemia was reported in 8 patients, and grade 2 and 3 neutropenia was recorded in 2 and 3 patients, respectively. Sixty-one percent of the patients completed the planned treatment. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Chemotherapy in very elderly patients is feasible with an acceptable toxicity profile. Careful evaluation of PS and assessment of physical and psychological health are necessary to predict tolerability of chemotherapy. A weekly schedule is better tolerated in this setting.</jats:p> Chemotherapy in Elderly Patients with Gynecological Cancer Oncology
spellingShingle Palaia, Innocenza, Loprete, Elisa, Musella, Angela, Marchetti, Claudia, Di Donato, Violante, Bellati, Filippo, Benedetti Panici, Pierluigi, Oncology, Chemotherapy in Elderly Patients with Gynecological Cancer, Cancer Research, Oncology, General Medicine
title Chemotherapy in Elderly Patients with Gynecological Cancer
title_full Chemotherapy in Elderly Patients with Gynecological Cancer
title_fullStr Chemotherapy in Elderly Patients with Gynecological Cancer
title_full_unstemmed Chemotherapy in Elderly Patients with Gynecological Cancer
title_short Chemotherapy in Elderly Patients with Gynecological Cancer
title_sort chemotherapy in elderly patients with gynecological cancer
title_unstemmed Chemotherapy in Elderly Patients with Gynecological Cancer
topic Cancer Research, Oncology, General Medicine
url http://dx.doi.org/10.1159/000350859