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Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity

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Bibliographische Detailangaben
Zeitschriftentitel: Chemical Biology & Drug Design
Personen und Körperschaften: Lopes, Nicolas S., Ciscato, Luiz Francisco M. L.
In: Chemical Biology & Drug Design, 91, 2018, 1, S. 328-331
Medientyp: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
author_facet Lopes, Nicolas S.
Ciscato, Luiz Francisco M. L.
Lopes, Nicolas S.
Ciscato, Luiz Francisco M. L.
author Lopes, Nicolas S.
Ciscato, Luiz Francisco M. L.
spellingShingle Lopes, Nicolas S.
Ciscato, Luiz Francisco M. L.
Chemical Biology & Drug Design
Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
Molecular Medicine
Biochemistry
Drug Discovery
Pharmacology
Organic Chemistry
author_sort lopes, nicolas s.
spelling Lopes, Nicolas S. Ciscato, Luiz Francisco M. L. 1747-0277 1747-0285 Wiley Molecular Medicine Biochemistry Drug Discovery Pharmacology Organic Chemistry http://dx.doi.org/10.1111/cbdd.13056 <jats:p>The Fenton‐like reductive cleavage of antimalarial peroxides like artemisinin by iron(II) species is a chemical reaction whose mechanistic pathway has not been yet fully understood; it is, however, known that there is considerable production of radical species centered at both the oxygen and carbon, which are important to the therapeutical effects of those compounds. This article reports kinetic data for the reaction of artemisinin and two model 1,2,4‐trioxolanes with iron(II) species and also a mechanistic interpretation of this reductive cleavage from transition state thermodynamics. The suggestion of the presence of an enhancing specific factor inside the <jats:italic>plasmodium</jats:italic> is made.</jats:p> Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity Chemical Biology & Drug Design
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title Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
title_unstemmed Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
title_full Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
title_fullStr Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
title_full_unstemmed Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
title_short Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
title_sort kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(ii): new evidence for the source of antimalarial activity
topic Molecular Medicine
Biochemistry
Drug Discovery
Pharmacology
Organic Chemistry
url http://dx.doi.org/10.1111/cbdd.13056
publishDate 2018
physical 328-331
description <jats:p>The Fenton‐like reductive cleavage of antimalarial peroxides like artemisinin by iron(II) species is a chemical reaction whose mechanistic pathway has not been yet fully understood; it is, however, known that there is considerable production of radical species centered at both the oxygen and carbon, which are important to the therapeutical effects of those compounds. This article reports kinetic data for the reaction of artemisinin and two model 1,2,4‐trioxolanes with iron(II) species and also a mechanistic interpretation of this reductive cleavage from transition state thermodynamics. The suggestion of the presence of an enhancing specific factor inside the <jats:italic>plasmodium</jats:italic> is made.</jats:p>
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author Lopes, Nicolas S., Ciscato, Luiz Francisco M. L.
author_facet Lopes, Nicolas S., Ciscato, Luiz Francisco M. L., Lopes, Nicolas S., Ciscato, Luiz Francisco M. L.
author_sort lopes, nicolas s.
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container_title Chemical Biology & Drug Design
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description <jats:p>The Fenton‐like reductive cleavage of antimalarial peroxides like artemisinin by iron(II) species is a chemical reaction whose mechanistic pathway has not been yet fully understood; it is, however, known that there is considerable production of radical species centered at both the oxygen and carbon, which are important to the therapeutical effects of those compounds. This article reports kinetic data for the reaction of artemisinin and two model 1,2,4‐trioxolanes with iron(II) species and also a mechanistic interpretation of this reductive cleavage from transition state thermodynamics. The suggestion of the presence of an enhancing specific factor inside the <jats:italic>plasmodium</jats:italic> is made.</jats:p>
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spelling Lopes, Nicolas S. Ciscato, Luiz Francisco M. L. 1747-0277 1747-0285 Wiley Molecular Medicine Biochemistry Drug Discovery Pharmacology Organic Chemistry http://dx.doi.org/10.1111/cbdd.13056 <jats:p>The Fenton‐like reductive cleavage of antimalarial peroxides like artemisinin by iron(II) species is a chemical reaction whose mechanistic pathway has not been yet fully understood; it is, however, known that there is considerable production of radical species centered at both the oxygen and carbon, which are important to the therapeutical effects of those compounds. This article reports kinetic data for the reaction of artemisinin and two model 1,2,4‐trioxolanes with iron(II) species and also a mechanistic interpretation of this reductive cleavage from transition state thermodynamics. The suggestion of the presence of an enhancing specific factor inside the <jats:italic>plasmodium</jats:italic> is made.</jats:p> Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity Chemical Biology & Drug Design
spellingShingle Lopes, Nicolas S., Ciscato, Luiz Francisco M. L., Chemical Biology & Drug Design, Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity, Molecular Medicine, Biochemistry, Drug Discovery, Pharmacology, Organic Chemistry
title Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
title_full Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
title_fullStr Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
title_full_unstemmed Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
title_short Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
title_sort kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(ii): new evidence for the source of antimalarial activity
title_unstemmed Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
topic Molecular Medicine, Biochemistry, Drug Discovery, Pharmacology, Organic Chemistry
url http://dx.doi.org/10.1111/cbdd.13056