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Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity
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Zeitschriftentitel: | Chemical Biology & Drug Design |
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Personen und Körperschaften: | , |
In: | Chemical Biology & Drug Design, 91, 2018, 1, S. 328-331 |
Medientyp: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Wiley
|
Schlagwörter: |
author_facet |
Lopes, Nicolas S. Ciscato, Luiz Francisco M. L. Lopes, Nicolas S. Ciscato, Luiz Francisco M. L. |
---|---|
author |
Lopes, Nicolas S. Ciscato, Luiz Francisco M. L. |
spellingShingle |
Lopes, Nicolas S. Ciscato, Luiz Francisco M. L. Chemical Biology & Drug Design Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity Molecular Medicine Biochemistry Drug Discovery Pharmacology Organic Chemistry |
author_sort |
lopes, nicolas s. |
spelling |
Lopes, Nicolas S. Ciscato, Luiz Francisco M. L. 1747-0277 1747-0285 Wiley Molecular Medicine Biochemistry Drug Discovery Pharmacology Organic Chemistry http://dx.doi.org/10.1111/cbdd.13056 <jats:p>The Fenton‐like reductive cleavage of antimalarial peroxides like artemisinin by iron(II) species is a chemical reaction whose mechanistic pathway has not been yet fully understood; it is, however, known that there is considerable production of radical species centered at both the oxygen and carbon, which are important to the therapeutical effects of those compounds. This article reports kinetic data for the reaction of artemisinin and two model 1,2,4‐trioxolanes with iron(II) species and also a mechanistic interpretation of this reductive cleavage from transition state thermodynamics. The suggestion of the presence of an enhancing specific factor inside the <jats:italic>plasmodium</jats:italic> is made.</jats:p> Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity Chemical Biology & Drug Design |
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10.1111/cbdd.13056 |
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title |
Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity |
title_unstemmed |
Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity |
title_full |
Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity |
title_fullStr |
Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity |
title_full_unstemmed |
Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity |
title_short |
Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity |
title_sort |
kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(ii): new evidence for the source of antimalarial activity |
topic |
Molecular Medicine Biochemistry Drug Discovery Pharmacology Organic Chemistry |
url |
http://dx.doi.org/10.1111/cbdd.13056 |
publishDate |
2018 |
physical |
328-331 |
description |
<jats:p>The Fenton‐like reductive cleavage of antimalarial peroxides like artemisinin by iron(II) species is a chemical reaction whose mechanistic pathway has not been yet fully understood; it is, however, known that there is considerable production of radical species centered at both the oxygen and carbon, which are important to the therapeutical effects of those compounds. This article reports kinetic data for the reaction of artemisinin and two model 1,2,4‐trioxolanes with iron(II) species and also a mechanistic interpretation of this reductive cleavage from transition state thermodynamics. The suggestion of the presence of an enhancing specific factor inside the <jats:italic>plasmodium</jats:italic> is made.</jats:p> |
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author | Lopes, Nicolas S., Ciscato, Luiz Francisco M. L. |
author_facet | Lopes, Nicolas S., Ciscato, Luiz Francisco M. L., Lopes, Nicolas S., Ciscato, Luiz Francisco M. L. |
author_sort | lopes, nicolas s. |
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container_title | Chemical Biology & Drug Design |
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description | <jats:p>The Fenton‐like reductive cleavage of antimalarial peroxides like artemisinin by iron(II) species is a chemical reaction whose mechanistic pathway has not been yet fully understood; it is, however, known that there is considerable production of radical species centered at both the oxygen and carbon, which are important to the therapeutical effects of those compounds. This article reports kinetic data for the reaction of artemisinin and two model 1,2,4‐trioxolanes with iron(II) species and also a mechanistic interpretation of this reductive cleavage from transition state thermodynamics. The suggestion of the presence of an enhancing specific factor inside the <jats:italic>plasmodium</jats:italic> is made.</jats:p> |
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imprint | Wiley, 2018 |
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source_id | 49 |
spelling | Lopes, Nicolas S. Ciscato, Luiz Francisco M. L. 1747-0277 1747-0285 Wiley Molecular Medicine Biochemistry Drug Discovery Pharmacology Organic Chemistry http://dx.doi.org/10.1111/cbdd.13056 <jats:p>The Fenton‐like reductive cleavage of antimalarial peroxides like artemisinin by iron(II) species is a chemical reaction whose mechanistic pathway has not been yet fully understood; it is, however, known that there is considerable production of radical species centered at both the oxygen and carbon, which are important to the therapeutical effects of those compounds. This article reports kinetic data for the reaction of artemisinin and two model 1,2,4‐trioxolanes with iron(II) species and also a mechanistic interpretation of this reductive cleavage from transition state thermodynamics. The suggestion of the presence of an enhancing specific factor inside the <jats:italic>plasmodium</jats:italic> is made.</jats:p> Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity Chemical Biology & Drug Design |
spellingShingle | Lopes, Nicolas S., Ciscato, Luiz Francisco M. L., Chemical Biology & Drug Design, Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity, Molecular Medicine, Biochemistry, Drug Discovery, Pharmacology, Organic Chemistry |
title | Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity |
title_full | Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity |
title_fullStr | Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity |
title_full_unstemmed | Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity |
title_short | Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity |
title_sort | kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(ii): new evidence for the source of antimalarial activity |
title_unstemmed | Kinetic parameters for the reaction of 1,2,4‐trioxolanes and artemisinin with iron(II): New evidence for the source of antimalarial activity |
topic | Molecular Medicine, Biochemistry, Drug Discovery, Pharmacology, Organic Chemistry |
url | http://dx.doi.org/10.1111/cbdd.13056 |