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Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice

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Zeitschriftentitel: CNS Neuroscience & Therapeutics
Personen und Körperschaften: Liu, Yan, Xu, Yan‐Feng, Zhang, Ling, Huang, Lan, Yu, Pin, Zhu, Hua, Deng, Wei, Qin, Chuan
In: CNS Neuroscience & Therapeutics, 23, 2017, 7, S. 590-604
Medientyp: E-Article
Sprache: Englisch
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Wiley
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author_facet Liu, Yan
Xu, Yan‐Feng
Zhang, Ling
Huang, Lan
Yu, Pin
Zhu, Hua
Deng, Wei
Qin, Chuan
Liu, Yan
Xu, Yan‐Feng
Zhang, Ling
Huang, Lan
Yu, Pin
Zhu, Hua
Deng, Wei
Qin, Chuan
author Liu, Yan
Xu, Yan‐Feng
Zhang, Ling
Huang, Lan
Yu, Pin
Zhu, Hua
Deng, Wei
Qin, Chuan
spellingShingle Liu, Yan
Xu, Yan‐Feng
Zhang, Ling
Huang, Lan
Yu, Pin
Zhu, Hua
Deng, Wei
Qin, Chuan
CNS Neuroscience & Therapeutics
Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
Pharmacology (medical)
Physiology (medical)
Psychiatry and Mental health
Pharmacology
author_sort liu, yan
spelling Liu, Yan Xu, Yan‐Feng Zhang, Ling Huang, Lan Yu, Pin Zhu, Hua Deng, Wei Qin, Chuan 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/cns.12706 <jats:title> <jats:bold>Summary</jats:bold> </jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Alzheimer's disease (<jats:styled-content style="fixed-case">AD</jats:styled-content>), a progressive development dementia, is increasingly impacting patients’ living conditions worldwide. Despite medical care and funding support, there are still no highly individualized drugs and practical strategies for clinical prevention and treatment. Developmentally regulated brain protein (abbreviated as Drebrin or Dbn, also known as Dbn1 in mouse) exists in neurons, especially in dendrites, and is an actin‐binding protein that modulates synaptic morphology and long‐term memory. However, the majority of previous studies have focused on its upstream proteins and neglected the impact Drebrin has on behavior and <jats:styled-content style="fixed-case">AD</jats:styled-content> in vivo.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Here, we tracked the behavioral performances of 4‐, 8‐, 12‐, and 16‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice and investigated the expression level of Drebrin in their hippocampi. A Pearson correlation analysis between Drebrin levels and behavioral data was performed. Subsequently, 2‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐zsGreen‐Dbn1 vector, composing the <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 group, and sex‐ and age‐matched <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐tdTomato vector to serve as the control group. All mice were conducted behavioral tests and molecular detection 6 months later.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>(i) The expression of Drebrin is decreased in the hippocampus of aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice compared with that of age‐matched <jats:styled-content style="fixed-case">WT</jats:styled-content> and young adult <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (ii) cognitive ability of <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1 mice decreases with age; (iii) Drebrin protein expression in the hippocampus correlates with behavioral performance in different aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (iv) cognitive ability improved significantly in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (v) the expression level of Drebrin in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mouse hippocampus was significantly increased; (vi) the pathological lesion of <jats:styled-content style="fixed-case">AD</jats:styled-content> was alleviated in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (vii) the filamentous actin (F‐actin) and microtubule‐associated protein 2(<jats:styled-content style="fixed-case">MAP</jats:styled-content>‐2) in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice were notably more than control mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In this study, an effective expression of Drebrin improves cognitive abilities and alleviates lesions in an <jats:styled-content style="fixed-case">AD</jats:styled-content> mouse model. These results may provide some valid resources for therapy and research of <jats:styled-content style="fixed-case">AD</jats:styled-content>.</jats:p></jats:sec> Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in <scp>APP</scp> (swe)/<scp>PS</scp>1 (ΔE9) mice CNS Neuroscience & Therapeutics
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recordtype ai
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series CNS Neuroscience & Therapeutics
source_id 49
title Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
title_unstemmed Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
title_full Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
title_fullStr Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
title_full_unstemmed Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
title_short Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
title_sort effective expression of drebrin in hippocampus improves cognitive function and alleviates lesions of alzheimer's disease in <scp>app</scp> (swe)/<scp>ps</scp>1 (δe9) mice
topic Pharmacology (medical)
Physiology (medical)
Psychiatry and Mental health
Pharmacology
url http://dx.doi.org/10.1111/cns.12706
publishDate 2017
physical 590-604
description <jats:title> <jats:bold>Summary</jats:bold> </jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Alzheimer's disease (<jats:styled-content style="fixed-case">AD</jats:styled-content>), a progressive development dementia, is increasingly impacting patients’ living conditions worldwide. Despite medical care and funding support, there are still no highly individualized drugs and practical strategies for clinical prevention and treatment. Developmentally regulated brain protein (abbreviated as Drebrin or Dbn, also known as Dbn1 in mouse) exists in neurons, especially in dendrites, and is an actin‐binding protein that modulates synaptic morphology and long‐term memory. However, the majority of previous studies have focused on its upstream proteins and neglected the impact Drebrin has on behavior and <jats:styled-content style="fixed-case">AD</jats:styled-content> in vivo.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Here, we tracked the behavioral performances of 4‐, 8‐, 12‐, and 16‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice and investigated the expression level of Drebrin in their hippocampi. A Pearson correlation analysis between Drebrin levels and behavioral data was performed. Subsequently, 2‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐zsGreen‐Dbn1 vector, composing the <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 group, and sex‐ and age‐matched <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐tdTomato vector to serve as the control group. All mice were conducted behavioral tests and molecular detection 6 months later.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>(i) The expression of Drebrin is decreased in the hippocampus of aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice compared with that of age‐matched <jats:styled-content style="fixed-case">WT</jats:styled-content> and young adult <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (ii) cognitive ability of <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1 mice decreases with age; (iii) Drebrin protein expression in the hippocampus correlates with behavioral performance in different aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (iv) cognitive ability improved significantly in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (v) the expression level of Drebrin in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mouse hippocampus was significantly increased; (vi) the pathological lesion of <jats:styled-content style="fixed-case">AD</jats:styled-content> was alleviated in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (vii) the filamentous actin (F‐actin) and microtubule‐associated protein 2(<jats:styled-content style="fixed-case">MAP</jats:styled-content>‐2) in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice were notably more than control mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In this study, an effective expression of Drebrin improves cognitive abilities and alleviates lesions in an <jats:styled-content style="fixed-case">AD</jats:styled-content> mouse model. These results may provide some valid resources for therapy and research of <jats:styled-content style="fixed-case">AD</jats:styled-content>.</jats:p></jats:sec>
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author Liu, Yan, Xu, Yan‐Feng, Zhang, Ling, Huang, Lan, Yu, Pin, Zhu, Hua, Deng, Wei, Qin, Chuan
author_facet Liu, Yan, Xu, Yan‐Feng, Zhang, Ling, Huang, Lan, Yu, Pin, Zhu, Hua, Deng, Wei, Qin, Chuan, Liu, Yan, Xu, Yan‐Feng, Zhang, Ling, Huang, Lan, Yu, Pin, Zhu, Hua, Deng, Wei, Qin, Chuan
author_sort liu, yan
container_issue 7
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container_title CNS Neuroscience & Therapeutics
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description <jats:title> <jats:bold>Summary</jats:bold> </jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Alzheimer's disease (<jats:styled-content style="fixed-case">AD</jats:styled-content>), a progressive development dementia, is increasingly impacting patients’ living conditions worldwide. Despite medical care and funding support, there are still no highly individualized drugs and practical strategies for clinical prevention and treatment. Developmentally regulated brain protein (abbreviated as Drebrin or Dbn, also known as Dbn1 in mouse) exists in neurons, especially in dendrites, and is an actin‐binding protein that modulates synaptic morphology and long‐term memory. However, the majority of previous studies have focused on its upstream proteins and neglected the impact Drebrin has on behavior and <jats:styled-content style="fixed-case">AD</jats:styled-content> in vivo.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Here, we tracked the behavioral performances of 4‐, 8‐, 12‐, and 16‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice and investigated the expression level of Drebrin in their hippocampi. A Pearson correlation analysis between Drebrin levels and behavioral data was performed. Subsequently, 2‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐zsGreen‐Dbn1 vector, composing the <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 group, and sex‐ and age‐matched <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐tdTomato vector to serve as the control group. All mice were conducted behavioral tests and molecular detection 6 months later.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>(i) The expression of Drebrin is decreased in the hippocampus of aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice compared with that of age‐matched <jats:styled-content style="fixed-case">WT</jats:styled-content> and young adult <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (ii) cognitive ability of <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1 mice decreases with age; (iii) Drebrin protein expression in the hippocampus correlates with behavioral performance in different aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (iv) cognitive ability improved significantly in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (v) the expression level of Drebrin in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mouse hippocampus was significantly increased; (vi) the pathological lesion of <jats:styled-content style="fixed-case">AD</jats:styled-content> was alleviated in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (vii) the filamentous actin (F‐actin) and microtubule‐associated protein 2(<jats:styled-content style="fixed-case">MAP</jats:styled-content>‐2) in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice were notably more than control mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In this study, an effective expression of Drebrin improves cognitive abilities and alleviates lesions in an <jats:styled-content style="fixed-case">AD</jats:styled-content> mouse model. These results may provide some valid resources for therapy and research of <jats:styled-content style="fixed-case">AD</jats:styled-content>.</jats:p></jats:sec>
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spelling Liu, Yan Xu, Yan‐Feng Zhang, Ling Huang, Lan Yu, Pin Zhu, Hua Deng, Wei Qin, Chuan 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/cns.12706 <jats:title> <jats:bold>Summary</jats:bold> </jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Alzheimer's disease (<jats:styled-content style="fixed-case">AD</jats:styled-content>), a progressive development dementia, is increasingly impacting patients’ living conditions worldwide. Despite medical care and funding support, there are still no highly individualized drugs and practical strategies for clinical prevention and treatment. Developmentally regulated brain protein (abbreviated as Drebrin or Dbn, also known as Dbn1 in mouse) exists in neurons, especially in dendrites, and is an actin‐binding protein that modulates synaptic morphology and long‐term memory. However, the majority of previous studies have focused on its upstream proteins and neglected the impact Drebrin has on behavior and <jats:styled-content style="fixed-case">AD</jats:styled-content> in vivo.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Here, we tracked the behavioral performances of 4‐, 8‐, 12‐, and 16‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice and investigated the expression level of Drebrin in their hippocampi. A Pearson correlation analysis between Drebrin levels and behavioral data was performed. Subsequently, 2‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐zsGreen‐Dbn1 vector, composing the <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 group, and sex‐ and age‐matched <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐tdTomato vector to serve as the control group. All mice were conducted behavioral tests and molecular detection 6 months later.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>(i) The expression of Drebrin is decreased in the hippocampus of aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice compared with that of age‐matched <jats:styled-content style="fixed-case">WT</jats:styled-content> and young adult <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (ii) cognitive ability of <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1 mice decreases with age; (iii) Drebrin protein expression in the hippocampus correlates with behavioral performance in different aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (iv) cognitive ability improved significantly in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (v) the expression level of Drebrin in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mouse hippocampus was significantly increased; (vi) the pathological lesion of <jats:styled-content style="fixed-case">AD</jats:styled-content> was alleviated in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (vii) the filamentous actin (F‐actin) and microtubule‐associated protein 2(<jats:styled-content style="fixed-case">MAP</jats:styled-content>‐2) in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice were notably more than control mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In this study, an effective expression of Drebrin improves cognitive abilities and alleviates lesions in an <jats:styled-content style="fixed-case">AD</jats:styled-content> mouse model. These results may provide some valid resources for therapy and research of <jats:styled-content style="fixed-case">AD</jats:styled-content>.</jats:p></jats:sec> Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in <scp>APP</scp> (swe)/<scp>PS</scp>1 (ΔE9) mice CNS Neuroscience & Therapeutics
spellingShingle Liu, Yan, Xu, Yan‐Feng, Zhang, Ling, Huang, Lan, Yu, Pin, Zhu, Hua, Deng, Wei, Qin, Chuan, CNS Neuroscience & Therapeutics, Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice, Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology
title Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
title_full Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
title_fullStr Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
title_full_unstemmed Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
title_short Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
title_sort effective expression of drebrin in hippocampus improves cognitive function and alleviates lesions of alzheimer's disease in <scp>app</scp> (swe)/<scp>ps</scp>1 (δe9) mice
title_unstemmed Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
topic Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology
url http://dx.doi.org/10.1111/cns.12706