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Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice
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Zeitschriftentitel: | CNS Neuroscience & Therapeutics |
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Personen und Körperschaften: | , , , , , , , |
In: | CNS Neuroscience & Therapeutics, 23, 2017, 7, S. 590-604 |
Medientyp: | E-Article |
Sprache: | Englisch |
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author_facet |
Liu, Yan Xu, Yan‐Feng Zhang, Ling Huang, Lan Yu, Pin Zhu, Hua Deng, Wei Qin, Chuan Liu, Yan Xu, Yan‐Feng Zhang, Ling Huang, Lan Yu, Pin Zhu, Hua Deng, Wei Qin, Chuan |
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author |
Liu, Yan Xu, Yan‐Feng Zhang, Ling Huang, Lan Yu, Pin Zhu, Hua Deng, Wei Qin, Chuan |
spellingShingle |
Liu, Yan Xu, Yan‐Feng Zhang, Ling Huang, Lan Yu, Pin Zhu, Hua Deng, Wei Qin, Chuan CNS Neuroscience & Therapeutics Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
author_sort |
liu, yan |
spelling |
Liu, Yan Xu, Yan‐Feng Zhang, Ling Huang, Lan Yu, Pin Zhu, Hua Deng, Wei Qin, Chuan 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/cns.12706 <jats:title> <jats:bold>Summary</jats:bold> </jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Alzheimer's disease (<jats:styled-content style="fixed-case">AD</jats:styled-content>), a progressive development dementia, is increasingly impacting patients’ living conditions worldwide. Despite medical care and funding support, there are still no highly individualized drugs and practical strategies for clinical prevention and treatment. Developmentally regulated brain protein (abbreviated as Drebrin or Dbn, also known as Dbn1 in mouse) exists in neurons, especially in dendrites, and is an actin‐binding protein that modulates synaptic morphology and long‐term memory. However, the majority of previous studies have focused on its upstream proteins and neglected the impact Drebrin has on behavior and <jats:styled-content style="fixed-case">AD</jats:styled-content> in vivo.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Here, we tracked the behavioral performances of 4‐, 8‐, 12‐, and 16‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice and investigated the expression level of Drebrin in their hippocampi. A Pearson correlation analysis between Drebrin levels and behavioral data was performed. Subsequently, 2‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐zsGreen‐Dbn1 vector, composing the <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 group, and sex‐ and age‐matched <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐tdTomato vector to serve as the control group. All mice were conducted behavioral tests and molecular detection 6 months later.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>(i) The expression of Drebrin is decreased in the hippocampus of aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice compared with that of age‐matched <jats:styled-content style="fixed-case">WT</jats:styled-content> and young adult <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (ii) cognitive ability of <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1 mice decreases with age; (iii) Drebrin protein expression in the hippocampus correlates with behavioral performance in different aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (iv) cognitive ability improved significantly in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (v) the expression level of Drebrin in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mouse hippocampus was significantly increased; (vi) the pathological lesion of <jats:styled-content style="fixed-case">AD</jats:styled-content> was alleviated in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (vii) the filamentous actin (F‐actin) and microtubule‐associated protein 2(<jats:styled-content style="fixed-case">MAP</jats:styled-content>‐2) in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice were notably more than control mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In this study, an effective expression of Drebrin improves cognitive abilities and alleviates lesions in an <jats:styled-content style="fixed-case">AD</jats:styled-content> mouse model. These results may provide some valid resources for therapy and research of <jats:styled-content style="fixed-case">AD</jats:styled-content>.</jats:p></jats:sec> Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in <scp>APP</scp> (swe)/<scp>PS</scp>1 (ΔE9) mice CNS Neuroscience & Therapeutics |
doi_str_mv |
10.1111/cns.12706 |
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Chemie und Pharmazie Biologie Medizin Psychologie |
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2017 |
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Wiley |
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CNS Neuroscience & Therapeutics |
source_id |
49 |
title |
Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice |
title_unstemmed |
Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice |
title_full |
Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice |
title_fullStr |
Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice |
title_full_unstemmed |
Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice |
title_short |
Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice |
title_sort |
effective expression of drebrin in hippocampus improves cognitive function and alleviates lesions of alzheimer's disease in <scp>app</scp> (swe)/<scp>ps</scp>1 (δe9) mice |
topic |
Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology |
url |
http://dx.doi.org/10.1111/cns.12706 |
publishDate |
2017 |
physical |
590-604 |
description |
<jats:title>
<jats:bold>Summary</jats:bold>
</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Alzheimer's disease (<jats:styled-content style="fixed-case">AD</jats:styled-content>), a progressive development dementia, is increasingly impacting patients’ living conditions worldwide. Despite medical care and funding support, there are still no highly individualized drugs and practical strategies for clinical prevention and treatment. Developmentally regulated brain protein (abbreviated as Drebrin or Dbn, also known as Dbn1 in mouse) exists in neurons, especially in dendrites, and is an actin‐binding protein that modulates synaptic morphology and long‐term memory. However, the majority of previous studies have focused on its upstream proteins and neglected the impact Drebrin has on behavior and <jats:styled-content style="fixed-case">AD</jats:styled-content> in vivo.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Here, we tracked the behavioral performances of 4‐, 8‐, 12‐, and 16‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice and investigated the expression level of Drebrin in their hippocampi. A Pearson correlation analysis between Drebrin levels and behavioral data was performed. Subsequently, 2‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐zsGreen‐Dbn1 vector, composing the <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 group, and sex‐ and age‐matched <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐tdTomato vector to serve as the control group. All mice were conducted behavioral tests and molecular detection 6 months later.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>(i) The expression of Drebrin is decreased in the hippocampus of aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice compared with that of age‐matched <jats:styled-content style="fixed-case">WT</jats:styled-content> and young adult <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (ii) cognitive ability of <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1 mice decreases with age; (iii) Drebrin protein expression in the hippocampus correlates with behavioral performance in different aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (iv) cognitive ability improved significantly in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (v) the expression level of Drebrin in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mouse hippocampus was significantly increased; (vi) the pathological lesion of <jats:styled-content style="fixed-case">AD</jats:styled-content> was alleviated in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (vii) the filamentous actin (F‐actin) and microtubule‐associated protein 2(<jats:styled-content style="fixed-case">MAP</jats:styled-content>‐2) in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice were notably more than control mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In this study, an effective expression of Drebrin improves cognitive abilities and alleviates lesions in an <jats:styled-content style="fixed-case">AD</jats:styled-content> mouse model. These results may provide some valid resources for therapy and research of <jats:styled-content style="fixed-case">AD</jats:styled-content>.</jats:p></jats:sec> |
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author | Liu, Yan, Xu, Yan‐Feng, Zhang, Ling, Huang, Lan, Yu, Pin, Zhu, Hua, Deng, Wei, Qin, Chuan |
author_facet | Liu, Yan, Xu, Yan‐Feng, Zhang, Ling, Huang, Lan, Yu, Pin, Zhu, Hua, Deng, Wei, Qin, Chuan, Liu, Yan, Xu, Yan‐Feng, Zhang, Ling, Huang, Lan, Yu, Pin, Zhu, Hua, Deng, Wei, Qin, Chuan |
author_sort | liu, yan |
container_issue | 7 |
container_start_page | 590 |
container_title | CNS Neuroscience & Therapeutics |
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description | <jats:title> <jats:bold>Summary</jats:bold> </jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Alzheimer's disease (<jats:styled-content style="fixed-case">AD</jats:styled-content>), a progressive development dementia, is increasingly impacting patients’ living conditions worldwide. Despite medical care and funding support, there are still no highly individualized drugs and practical strategies for clinical prevention and treatment. Developmentally regulated brain protein (abbreviated as Drebrin or Dbn, also known as Dbn1 in mouse) exists in neurons, especially in dendrites, and is an actin‐binding protein that modulates synaptic morphology and long‐term memory. However, the majority of previous studies have focused on its upstream proteins and neglected the impact Drebrin has on behavior and <jats:styled-content style="fixed-case">AD</jats:styled-content> in vivo.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Here, we tracked the behavioral performances of 4‐, 8‐, 12‐, and 16‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice and investigated the expression level of Drebrin in their hippocampi. A Pearson correlation analysis between Drebrin levels and behavioral data was performed. Subsequently, 2‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐zsGreen‐Dbn1 vector, composing the <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 group, and sex‐ and age‐matched <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐tdTomato vector to serve as the control group. All mice were conducted behavioral tests and molecular detection 6 months later.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>(i) The expression of Drebrin is decreased in the hippocampus of aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice compared with that of age‐matched <jats:styled-content style="fixed-case">WT</jats:styled-content> and young adult <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (ii) cognitive ability of <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1 mice decreases with age; (iii) Drebrin protein expression in the hippocampus correlates with behavioral performance in different aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (iv) cognitive ability improved significantly in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (v) the expression level of Drebrin in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mouse hippocampus was significantly increased; (vi) the pathological lesion of <jats:styled-content style="fixed-case">AD</jats:styled-content> was alleviated in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (vii) the filamentous actin (F‐actin) and microtubule‐associated protein 2(<jats:styled-content style="fixed-case">MAP</jats:styled-content>‐2) in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice were notably more than control mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In this study, an effective expression of Drebrin improves cognitive abilities and alleviates lesions in an <jats:styled-content style="fixed-case">AD</jats:styled-content> mouse model. These results may provide some valid resources for therapy and research of <jats:styled-content style="fixed-case">AD</jats:styled-content>.</jats:p></jats:sec> |
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spelling | Liu, Yan Xu, Yan‐Feng Zhang, Ling Huang, Lan Yu, Pin Zhu, Hua Deng, Wei Qin, Chuan 1755-5930 1755-5949 Wiley Pharmacology (medical) Physiology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1111/cns.12706 <jats:title> <jats:bold>Summary</jats:bold> </jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Alzheimer's disease (<jats:styled-content style="fixed-case">AD</jats:styled-content>), a progressive development dementia, is increasingly impacting patients’ living conditions worldwide. Despite medical care and funding support, there are still no highly individualized drugs and practical strategies for clinical prevention and treatment. Developmentally regulated brain protein (abbreviated as Drebrin or Dbn, also known as Dbn1 in mouse) exists in neurons, especially in dendrites, and is an actin‐binding protein that modulates synaptic morphology and long‐term memory. However, the majority of previous studies have focused on its upstream proteins and neglected the impact Drebrin has on behavior and <jats:styled-content style="fixed-case">AD</jats:styled-content> in vivo.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Here, we tracked the behavioral performances of 4‐, 8‐, 12‐, and 16‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice and investigated the expression level of Drebrin in their hippocampi. A Pearson correlation analysis between Drebrin levels and behavioral data was performed. Subsequently, 2‐month‐old <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐zsGreen‐Dbn1 vector, composing the <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 group, and sex‐ and age‐matched <jats:styled-content style="fixed-case">AD</jats:styled-content> mice were injected with <jats:styled-content style="fixed-case">rAAV</jats:styled-content>‐tdTomato vector to serve as the control group. All mice were conducted behavioral tests and molecular detection 6 months later.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>(i) The expression of Drebrin is decreased in the hippocampus of aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice compared with that of age‐matched <jats:styled-content style="fixed-case">WT</jats:styled-content> and young adult <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (ii) cognitive ability of <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1 mice decreases with age; (iii) Drebrin protein expression in the hippocampus correlates with behavioral performance in different aged <jats:styled-content style="fixed-case">AD</jats:styled-content> mice; (iv) cognitive ability improved significantly in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (v) the expression level of Drebrin in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mouse hippocampus was significantly increased; (vi) the pathological lesion of <jats:styled-content style="fixed-case">AD</jats:styled-content> was alleviated in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice; (vii) the filamentous actin (F‐actin) and microtubule‐associated protein 2(<jats:styled-content style="fixed-case">MAP</jats:styled-content>‐2) in <jats:styled-content style="fixed-case">APP</jats:styled-content>/<jats:styled-content style="fixed-case">PS</jats:styled-content>1‐Dbn1 mice were notably more than control mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In this study, an effective expression of Drebrin improves cognitive abilities and alleviates lesions in an <jats:styled-content style="fixed-case">AD</jats:styled-content> mouse model. These results may provide some valid resources for therapy and research of <jats:styled-content style="fixed-case">AD</jats:styled-content>.</jats:p></jats:sec> Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in <scp>APP</scp> (swe)/<scp>PS</scp>1 (ΔE9) mice CNS Neuroscience & Therapeutics |
spellingShingle | Liu, Yan, Xu, Yan‐Feng, Zhang, Ling, Huang, Lan, Yu, Pin, Zhu, Hua, Deng, Wei, Qin, Chuan, CNS Neuroscience & Therapeutics, Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice, Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
title | Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice |
title_full | Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice |
title_fullStr | Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice |
title_full_unstemmed | Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice |
title_short | Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice |
title_sort | effective expression of drebrin in hippocampus improves cognitive function and alleviates lesions of alzheimer's disease in <scp>app</scp> (swe)/<scp>ps</scp>1 (δe9) mice |
title_unstemmed | Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice |
topic | Pharmacology (medical), Physiology (medical), Psychiatry and Mental health, Pharmacology |
url | http://dx.doi.org/10.1111/cns.12706 |