Eintrag weiter verarbeiten
Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat
Gespeichert in:
| Zeitschriftentitel: | The FEBS Journal |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | The FEBS Journal, 286, 2019, 14, S. 2753-2768 |
| Medientyp: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Cui, Xianwei Xiao, Wen You, Lianghui Zhang, Fan Cao, Xinguo Feng, Jie Shen, Dan Li, Yun Wang, Yan Ji, Chenbo Guo, Xirong Cui, Xianwei Xiao, Wen You, Lianghui Zhang, Fan Cao, Xinguo Feng, Jie Shen, Dan Li, Yun Wang, Yan Ji, Chenbo Guo, Xirong |
|---|---|
| author |
Cui, Xianwei Xiao, Wen You, Lianghui Zhang, Fan Cao, Xinguo Feng, Jie Shen, Dan Li, Yun Wang, Yan Ji, Chenbo Guo, Xirong |
| spellingShingle |
Cui, Xianwei Xiao, Wen You, Lianghui Zhang, Fan Cao, Xinguo Feng, Jie Shen, Dan Li, Yun Wang, Yan Ji, Chenbo Guo, Xirong The FEBS Journal Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat Cell Biology Molecular Biology Biochemistry |
| author_sort |
cui, xianwei |
| spelling |
Cui, Xianwei Xiao, Wen You, Lianghui Zhang, Fan Cao, Xinguo Feng, Jie Shen, Dan Li, Yun Wang, Yan Ji, Chenbo Guo, Xirong 1742-464X 1742-4658 Wiley Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1111/febs.14838 <jats:p>It is well‐established that the mass and function of human brown adipose tissue (<jats:styled-content style="fixed-case">BAT</jats:styled-content>) declines with age. A key factor involved in age‐related impairment of <jats:styled-content style="fixed-case">BAT</jats:styled-content> is oxidative stress; however, there is a paucity of studies to date that have explored this relationship. Here, we characterized the age‐related molecular and functional alterations in <jats:styled-content style="fixed-case">BAT </jats:styled-content><jats:italic>in vivo</jats:italic> in mice of different ages, and treated human brown adipocytes with H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> to dissect the direct effect of oxidative stress <jats:italic>in vitro</jats:italic>. We further explored the structural and functional changes in <jats:styled-content style="fixed-case">BAT</jats:styled-content> in an oxidative stress‐induced mouse model of aging. We found that the progressive deterioration of <jats:styled-content style="fixed-case">BAT</jats:styled-content> was linked to oxidative stress, and observed that the adipogenesis and thermogenic program were significantly impaired upon H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> treatment <jats:italic>in vitro</jats:italic>. Moreover, antioxidant supplementation (e.g., vitamin E) attenuated oxidative stress and rescued <jats:styled-content style="fixed-case">BAT</jats:styled-content> activity decline, suggesting that age‐related injury in <jats:styled-content style="fixed-case">BAT</jats:styled-content> function can be partly alleviated by antioxidant treatment. Finally, we found that oxidative stress‐induced <jats:styled-content style="fixed-case">BAT</jats:styled-content> dysfunction is linked to the enhancement of autophagy. These results point to oxidative stress as being an important factor in age‐dependent functional impairment of <jats:styled-content style="fixed-case">BAT</jats:styled-content>.</jats:p> Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat The FEBS Journal |
| doi_str_mv |
10.1111/febs.14838 |
| facet_avail |
Online Free |
| finc_class_facet |
Chemie und Pharmazie Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9mZWJzLjE0ODM4 |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9mZWJzLjE0ODM4 |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Zi4 DE-Gla1 DE-15 DE-Pl11 DE-Rs1 DE-14 DE-105 DE-Ch1 DE-L229 |
| imprint |
Wiley, 2019 |
| imprint_str_mv |
Wiley, 2019 |
| issn |
1742-464X 1742-4658 |
| issn_str_mv |
1742-464X 1742-4658 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
cui2019ageinducedoxidativestressimpairsadipogenesisandthermogenesisinbrownfat |
| publishDateSort |
2019 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
The FEBS Journal |
| source_id |
49 |
| title |
Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| title_unstemmed |
Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| title_full |
Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| title_fullStr |
Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| title_full_unstemmed |
Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| title_short |
Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| title_sort |
age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| topic |
Cell Biology Molecular Biology Biochemistry |
| url |
http://dx.doi.org/10.1111/febs.14838 |
| publishDate |
2019 |
| physical |
2753-2768 |
| description |
<jats:p>It is well‐established that the mass and function of human brown adipose tissue (<jats:styled-content style="fixed-case">BAT</jats:styled-content>) declines with age. A key factor involved in age‐related impairment of <jats:styled-content style="fixed-case">BAT</jats:styled-content> is oxidative stress; however, there is a paucity of studies to date that have explored this relationship. Here, we characterized the age‐related molecular and functional alterations in <jats:styled-content style="fixed-case">BAT </jats:styled-content><jats:italic>in vivo</jats:italic> in mice of different ages, and treated human brown adipocytes with H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> to dissect the direct effect of oxidative stress <jats:italic>in vitro</jats:italic>. We further explored the structural and functional changes in <jats:styled-content style="fixed-case">BAT</jats:styled-content> in an oxidative stress‐induced mouse model of aging. We found that the progressive deterioration of <jats:styled-content style="fixed-case">BAT</jats:styled-content> was linked to oxidative stress, and observed that the adipogenesis and thermogenic program were significantly impaired upon H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> treatment <jats:italic>in vitro</jats:italic>. Moreover, antioxidant supplementation (e.g., vitamin E) attenuated oxidative stress and rescued <jats:styled-content style="fixed-case">BAT</jats:styled-content> activity decline, suggesting that age‐related injury in <jats:styled-content style="fixed-case">BAT</jats:styled-content> function can be partly alleviated by antioxidant treatment. Finally, we found that oxidative stress‐induced <jats:styled-content style="fixed-case">BAT</jats:styled-content> dysfunction is linked to the enhancement of autophagy. These results point to oxidative stress as being an important factor in age‐dependent functional impairment of <jats:styled-content style="fixed-case">BAT</jats:styled-content>.</jats:p> |
| container_issue |
14 |
| container_start_page |
2753 |
| container_title |
The FEBS Journal |
| container_volume |
286 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792342052660314112 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T16:29:40.818Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Age%E2%80%90induced+oxidative+stress+impairs+adipogenesis+and+thermogenesis+in+brown+fat&rft.date=2019-07-01&genre=article&issn=1742-4658&volume=286&issue=14&spage=2753&epage=2768&pages=2753-2768&jtitle=The+FEBS+Journal&atitle=Age%E2%80%90induced+oxidative+stress+impairs+adipogenesis+and+thermogenesis+in+brown+fat&aulast=Guo&aufirst=Xirong&rft_id=info%3Adoi%2F10.1111%2Ffebs.14838&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792342052660314112 |
| author | Cui, Xianwei, Xiao, Wen, You, Lianghui, Zhang, Fan, Cao, Xinguo, Feng, Jie, Shen, Dan, Li, Yun, Wang, Yan, Ji, Chenbo, Guo, Xirong |
| author_facet | Cui, Xianwei, Xiao, Wen, You, Lianghui, Zhang, Fan, Cao, Xinguo, Feng, Jie, Shen, Dan, Li, Yun, Wang, Yan, Ji, Chenbo, Guo, Xirong, Cui, Xianwei, Xiao, Wen, You, Lianghui, Zhang, Fan, Cao, Xinguo, Feng, Jie, Shen, Dan, Li, Yun, Wang, Yan, Ji, Chenbo, Guo, Xirong |
| author_sort | cui, xianwei |
| container_issue | 14 |
| container_start_page | 2753 |
| container_title | The FEBS Journal |
| container_volume | 286 |
| description | <jats:p>It is well‐established that the mass and function of human brown adipose tissue (<jats:styled-content style="fixed-case">BAT</jats:styled-content>) declines with age. A key factor involved in age‐related impairment of <jats:styled-content style="fixed-case">BAT</jats:styled-content> is oxidative stress; however, there is a paucity of studies to date that have explored this relationship. Here, we characterized the age‐related molecular and functional alterations in <jats:styled-content style="fixed-case">BAT </jats:styled-content><jats:italic>in vivo</jats:italic> in mice of different ages, and treated human brown adipocytes with H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> to dissect the direct effect of oxidative stress <jats:italic>in vitro</jats:italic>. We further explored the structural and functional changes in <jats:styled-content style="fixed-case">BAT</jats:styled-content> in an oxidative stress‐induced mouse model of aging. We found that the progressive deterioration of <jats:styled-content style="fixed-case">BAT</jats:styled-content> was linked to oxidative stress, and observed that the adipogenesis and thermogenic program were significantly impaired upon H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> treatment <jats:italic>in vitro</jats:italic>. Moreover, antioxidant supplementation (e.g., vitamin E) attenuated oxidative stress and rescued <jats:styled-content style="fixed-case">BAT</jats:styled-content> activity decline, suggesting that age‐related injury in <jats:styled-content style="fixed-case">BAT</jats:styled-content> function can be partly alleviated by antioxidant treatment. Finally, we found that oxidative stress‐induced <jats:styled-content style="fixed-case">BAT</jats:styled-content> dysfunction is linked to the enhancement of autophagy. These results point to oxidative stress as being an important factor in age‐dependent functional impairment of <jats:styled-content style="fixed-case">BAT</jats:styled-content>.</jats:p> |
| doi_str_mv | 10.1111/febs.14838 |
| facet_avail | Online, Free |
| finc_class_facet | Chemie und Pharmazie, Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTExMS9mZWJzLjE0ODM4 |
| imprint | Wiley, 2019 |
| imprint_str_mv | Wiley, 2019 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229 |
| issn | 1742-464X, 1742-4658 |
| issn_str_mv | 1742-464X, 1742-4658 |
| language | English |
| last_indexed | 2024-03-01T16:29:40.818Z |
| match_str | cui2019ageinducedoxidativestressimpairsadipogenesisandthermogenesisinbrownfat |
| mega_collection | Wiley (CrossRef) |
| physical | 2753-2768 |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | The FEBS Journal |
| source_id | 49 |
| spelling | Cui, Xianwei Xiao, Wen You, Lianghui Zhang, Fan Cao, Xinguo Feng, Jie Shen, Dan Li, Yun Wang, Yan Ji, Chenbo Guo, Xirong 1742-464X 1742-4658 Wiley Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1111/febs.14838 <jats:p>It is well‐established that the mass and function of human brown adipose tissue (<jats:styled-content style="fixed-case">BAT</jats:styled-content>) declines with age. A key factor involved in age‐related impairment of <jats:styled-content style="fixed-case">BAT</jats:styled-content> is oxidative stress; however, there is a paucity of studies to date that have explored this relationship. Here, we characterized the age‐related molecular and functional alterations in <jats:styled-content style="fixed-case">BAT </jats:styled-content><jats:italic>in vivo</jats:italic> in mice of different ages, and treated human brown adipocytes with H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> to dissect the direct effect of oxidative stress <jats:italic>in vitro</jats:italic>. We further explored the structural and functional changes in <jats:styled-content style="fixed-case">BAT</jats:styled-content> in an oxidative stress‐induced mouse model of aging. We found that the progressive deterioration of <jats:styled-content style="fixed-case">BAT</jats:styled-content> was linked to oxidative stress, and observed that the adipogenesis and thermogenic program were significantly impaired upon H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> treatment <jats:italic>in vitro</jats:italic>. Moreover, antioxidant supplementation (e.g., vitamin E) attenuated oxidative stress and rescued <jats:styled-content style="fixed-case">BAT</jats:styled-content> activity decline, suggesting that age‐related injury in <jats:styled-content style="fixed-case">BAT</jats:styled-content> function can be partly alleviated by antioxidant treatment. Finally, we found that oxidative stress‐induced <jats:styled-content style="fixed-case">BAT</jats:styled-content> dysfunction is linked to the enhancement of autophagy. These results point to oxidative stress as being an important factor in age‐dependent functional impairment of <jats:styled-content style="fixed-case">BAT</jats:styled-content>.</jats:p> Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat The FEBS Journal |
| spellingShingle | Cui, Xianwei, Xiao, Wen, You, Lianghui, Zhang, Fan, Cao, Xinguo, Feng, Jie, Shen, Dan, Li, Yun, Wang, Yan, Ji, Chenbo, Guo, Xirong, The FEBS Journal, Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat, Cell Biology, Molecular Biology, Biochemistry |
| title | Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| title_full | Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| title_fullStr | Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| title_full_unstemmed | Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| title_short | Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| title_sort | age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| title_unstemmed | Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat |
| topic | Cell Biology, Molecular Biology, Biochemistry |
| url | http://dx.doi.org/10.1111/febs.14838 |