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Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance

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Zeitschriftentitel: Journal of Gastroenterology and Hepatology
Personen und Körperschaften: Itou, Minoru, Kawaguchi, Takumi, Taniguchi, Eitaro, Sumie, Shuji, Oriishi, Tetsuharu, Mitsuyama, Keiichi, Tsuruta, Osamu, Ueno, Takato, Sata, Michio
In: Journal of Gastroenterology and Hepatology, 23, 2008, 2, S. 244-251
Medientyp: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
author_facet Itou, Minoru
Kawaguchi, Takumi
Taniguchi, Eitaro
Sumie, Shuji
Oriishi, Tetsuharu
Mitsuyama, Keiichi
Tsuruta, Osamu
Ueno, Takato
Sata, Michio
Itou, Minoru
Kawaguchi, Takumi
Taniguchi, Eitaro
Sumie, Shuji
Oriishi, Tetsuharu
Mitsuyama, Keiichi
Tsuruta, Osamu
Ueno, Takato
Sata, Michio
author Itou, Minoru
Kawaguchi, Takumi
Taniguchi, Eitaro
Sumie, Shuji
Oriishi, Tetsuharu
Mitsuyama, Keiichi
Tsuruta, Osamu
Ueno, Takato
Sata, Michio
spellingShingle Itou, Minoru
Kawaguchi, Takumi
Taniguchi, Eitaro
Sumie, Shuji
Oriishi, Tetsuharu
Mitsuyama, Keiichi
Tsuruta, Osamu
Ueno, Takato
Sata, Michio
Journal of Gastroenterology and Hepatology
Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
Gastroenterology
Hepatology
author_sort itou, minoru
spelling Itou, Minoru Kawaguchi, Takumi Taniguchi, Eitaro Sumie, Shuji Oriishi, Tetsuharu Mitsuyama, Keiichi Tsuruta, Osamu Ueno, Takato Sata, Michio 0815-9319 1440-1746 Wiley Gastroenterology Hepatology http://dx.doi.org/10.1111/j.1440-1746.2007.05183.x <jats:title>Abstract</jats:title><jats:p><jats:bold>Background and Aim: </jats:bold> The pathogenesis of hepatitis C virus (HCV)‐associated glucose intolerance remains unclear. Glucagon‐like peptide‐1 (GLP‐1), a gut hormone, synthesizes hepatic glycogen and is inactivated by dipeptidyl peptidase IV (DPPIV). The aims of this study were to investigate the alterations in the expression of GLP‐1 and DPPIV in HCV‐associated glucose intolerance.</jats:p><jats:p><jats:bold>Methods: </jats:bold> We enrolled patients with HCV‐ or hepatitis B virus (HBV)‐related liver disease (<jats:italic>n</jats:italic> = 94 and 37, respectively), patients with inflammatory bowel disease (IBD; <jats:italic>n</jats:italic> = 14) as disease controls, and healthy controls (<jats:italic>n</jats:italic> = 48). The serum or tissue GLP‐1 and DPPIV expression levels were determined by enzyme immunoassay, immunoblotting, or immunostaining. The hepatic glycogen content was assayed by periodic acid–Schiff staining.</jats:p><jats:p><jats:bold>Results: </jats:bold> The serum GLP‐1 levels were significantly decreased in the HCV group (4.9 ± 0.3 ng/mL) than those in the controls (7.5 ± 0.6 ng/mL), the HBV group (7.0 ± 0.5 ng/mL), or the IBD group (10.8 ± 1.0 ng/mL, <jats:italic>P</jats:italic> &lt; 0.01). Although the ileum GLP‐1 expression was not significantly different between the controls and the HCV group, the DPPIV expression was significantly increased in the ileum, liver, and serum in the HCV group. Hepatic glycogen content was decreased to a greater extent in the HCV group than that in the HBV group (127.5 ± 5.3 <jats:italic>vs</jats:italic> 187.7 ± 6.6 arbitrary units; <jats:italic>n</jats:italic> = 19, <jats:italic>P</jats:italic> &lt; 0.01).</jats:p><jats:p><jats:bold>Conclusion: </jats:bold> We demonstrated the altered expressions of GLP‐1 and DPPIV in patients with HCV‐associated glucose intolerance. Since hepatic glycogen synthesis, a GLP‐1 action, was impaired, the altered expressions of GLP‐1 and DPPIV may be involved in the development of HCV‐associated glucose intolerance.</jats:p> Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance Journal of Gastroenterology and Hepatology
doi_str_mv 10.1111/j.1440-1746.2007.05183.x
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title Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
title_unstemmed Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
title_full Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
title_fullStr Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
title_full_unstemmed Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
title_short Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
title_sort altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase iv in patients with hcv‐related glucose intolerance
topic Gastroenterology
Hepatology
url http://dx.doi.org/10.1111/j.1440-1746.2007.05183.x
publishDate 2008
physical 244-251
description <jats:title>Abstract</jats:title><jats:p><jats:bold>Background and Aim: </jats:bold> The pathogenesis of hepatitis C virus (HCV)‐associated glucose intolerance remains unclear. Glucagon‐like peptide‐1 (GLP‐1), a gut hormone, synthesizes hepatic glycogen and is inactivated by dipeptidyl peptidase IV (DPPIV). The aims of this study were to investigate the alterations in the expression of GLP‐1 and DPPIV in HCV‐associated glucose intolerance.</jats:p><jats:p><jats:bold>Methods: </jats:bold> We enrolled patients with HCV‐ or hepatitis B virus (HBV)‐related liver disease (<jats:italic>n</jats:italic> = 94 and 37, respectively), patients with inflammatory bowel disease (IBD; <jats:italic>n</jats:italic> = 14) as disease controls, and healthy controls (<jats:italic>n</jats:italic> = 48). The serum or tissue GLP‐1 and DPPIV expression levels were determined by enzyme immunoassay, immunoblotting, or immunostaining. The hepatic glycogen content was assayed by periodic acid–Schiff staining.</jats:p><jats:p><jats:bold>Results: </jats:bold> The serum GLP‐1 levels were significantly decreased in the HCV group (4.9 ± 0.3 ng/mL) than those in the controls (7.5 ± 0.6 ng/mL), the HBV group (7.0 ± 0.5 ng/mL), or the IBD group (10.8 ± 1.0 ng/mL, <jats:italic>P</jats:italic> &lt; 0.01). Although the ileum GLP‐1 expression was not significantly different between the controls and the HCV group, the DPPIV expression was significantly increased in the ileum, liver, and serum in the HCV group. Hepatic glycogen content was decreased to a greater extent in the HCV group than that in the HBV group (127.5 ± 5.3 <jats:italic>vs</jats:italic> 187.7 ± 6.6 arbitrary units; <jats:italic>n</jats:italic> = 19, <jats:italic>P</jats:italic> &lt; 0.01).</jats:p><jats:p><jats:bold>Conclusion: </jats:bold> We demonstrated the altered expressions of GLP‐1 and DPPIV in patients with HCV‐associated glucose intolerance. Since hepatic glycogen synthesis, a GLP‐1 action, was impaired, the altered expressions of GLP‐1 and DPPIV may be involved in the development of HCV‐associated glucose intolerance.</jats:p>
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author Itou, Minoru, Kawaguchi, Takumi, Taniguchi, Eitaro, Sumie, Shuji, Oriishi, Tetsuharu, Mitsuyama, Keiichi, Tsuruta, Osamu, Ueno, Takato, Sata, Michio
author_facet Itou, Minoru, Kawaguchi, Takumi, Taniguchi, Eitaro, Sumie, Shuji, Oriishi, Tetsuharu, Mitsuyama, Keiichi, Tsuruta, Osamu, Ueno, Takato, Sata, Michio, Itou, Minoru, Kawaguchi, Takumi, Taniguchi, Eitaro, Sumie, Shuji, Oriishi, Tetsuharu, Mitsuyama, Keiichi, Tsuruta, Osamu, Ueno, Takato, Sata, Michio
author_sort itou, minoru
container_issue 2
container_start_page 244
container_title Journal of Gastroenterology and Hepatology
container_volume 23
description <jats:title>Abstract</jats:title><jats:p><jats:bold>Background and Aim: </jats:bold> The pathogenesis of hepatitis C virus (HCV)‐associated glucose intolerance remains unclear. Glucagon‐like peptide‐1 (GLP‐1), a gut hormone, synthesizes hepatic glycogen and is inactivated by dipeptidyl peptidase IV (DPPIV). The aims of this study were to investigate the alterations in the expression of GLP‐1 and DPPIV in HCV‐associated glucose intolerance.</jats:p><jats:p><jats:bold>Methods: </jats:bold> We enrolled patients with HCV‐ or hepatitis B virus (HBV)‐related liver disease (<jats:italic>n</jats:italic> = 94 and 37, respectively), patients with inflammatory bowel disease (IBD; <jats:italic>n</jats:italic> = 14) as disease controls, and healthy controls (<jats:italic>n</jats:italic> = 48). The serum or tissue GLP‐1 and DPPIV expression levels were determined by enzyme immunoassay, immunoblotting, or immunostaining. The hepatic glycogen content was assayed by periodic acid–Schiff staining.</jats:p><jats:p><jats:bold>Results: </jats:bold> The serum GLP‐1 levels were significantly decreased in the HCV group (4.9 ± 0.3 ng/mL) than those in the controls (7.5 ± 0.6 ng/mL), the HBV group (7.0 ± 0.5 ng/mL), or the IBD group (10.8 ± 1.0 ng/mL, <jats:italic>P</jats:italic> &lt; 0.01). Although the ileum GLP‐1 expression was not significantly different between the controls and the HCV group, the DPPIV expression was significantly increased in the ileum, liver, and serum in the HCV group. Hepatic glycogen content was decreased to a greater extent in the HCV group than that in the HBV group (127.5 ± 5.3 <jats:italic>vs</jats:italic> 187.7 ± 6.6 arbitrary units; <jats:italic>n</jats:italic> = 19, <jats:italic>P</jats:italic> &lt; 0.01).</jats:p><jats:p><jats:bold>Conclusion: </jats:bold> We demonstrated the altered expressions of GLP‐1 and DPPIV in patients with HCV‐associated glucose intolerance. Since hepatic glycogen synthesis, a GLP‐1 action, was impaired, the altered expressions of GLP‐1 and DPPIV may be involved in the development of HCV‐associated glucose intolerance.</jats:p>
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spelling Itou, Minoru Kawaguchi, Takumi Taniguchi, Eitaro Sumie, Shuji Oriishi, Tetsuharu Mitsuyama, Keiichi Tsuruta, Osamu Ueno, Takato Sata, Michio 0815-9319 1440-1746 Wiley Gastroenterology Hepatology http://dx.doi.org/10.1111/j.1440-1746.2007.05183.x <jats:title>Abstract</jats:title><jats:p><jats:bold>Background and Aim: </jats:bold> The pathogenesis of hepatitis C virus (HCV)‐associated glucose intolerance remains unclear. Glucagon‐like peptide‐1 (GLP‐1), a gut hormone, synthesizes hepatic glycogen and is inactivated by dipeptidyl peptidase IV (DPPIV). The aims of this study were to investigate the alterations in the expression of GLP‐1 and DPPIV in HCV‐associated glucose intolerance.</jats:p><jats:p><jats:bold>Methods: </jats:bold> We enrolled patients with HCV‐ or hepatitis B virus (HBV)‐related liver disease (<jats:italic>n</jats:italic> = 94 and 37, respectively), patients with inflammatory bowel disease (IBD; <jats:italic>n</jats:italic> = 14) as disease controls, and healthy controls (<jats:italic>n</jats:italic> = 48). The serum or tissue GLP‐1 and DPPIV expression levels were determined by enzyme immunoassay, immunoblotting, or immunostaining. The hepatic glycogen content was assayed by periodic acid–Schiff staining.</jats:p><jats:p><jats:bold>Results: </jats:bold> The serum GLP‐1 levels were significantly decreased in the HCV group (4.9 ± 0.3 ng/mL) than those in the controls (7.5 ± 0.6 ng/mL), the HBV group (7.0 ± 0.5 ng/mL), or the IBD group (10.8 ± 1.0 ng/mL, <jats:italic>P</jats:italic> &lt; 0.01). Although the ileum GLP‐1 expression was not significantly different between the controls and the HCV group, the DPPIV expression was significantly increased in the ileum, liver, and serum in the HCV group. Hepatic glycogen content was decreased to a greater extent in the HCV group than that in the HBV group (127.5 ± 5.3 <jats:italic>vs</jats:italic> 187.7 ± 6.6 arbitrary units; <jats:italic>n</jats:italic> = 19, <jats:italic>P</jats:italic> &lt; 0.01).</jats:p><jats:p><jats:bold>Conclusion: </jats:bold> We demonstrated the altered expressions of GLP‐1 and DPPIV in patients with HCV‐associated glucose intolerance. Since hepatic glycogen synthesis, a GLP‐1 action, was impaired, the altered expressions of GLP‐1 and DPPIV may be involved in the development of HCV‐associated glucose intolerance.</jats:p> Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance Journal of Gastroenterology and Hepatology
spellingShingle Itou, Minoru, Kawaguchi, Takumi, Taniguchi, Eitaro, Sumie, Shuji, Oriishi, Tetsuharu, Mitsuyama, Keiichi, Tsuruta, Osamu, Ueno, Takato, Sata, Michio, Journal of Gastroenterology and Hepatology, Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance, Gastroenterology, Hepatology
title Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
title_full Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
title_fullStr Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
title_full_unstemmed Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
title_short Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
title_sort altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase iv in patients with hcv‐related glucose intolerance
title_unstemmed Altered expression of glucagon‐like peptide‐1 and dipeptidyl peptidase IV in patients with HCV‐related glucose intolerance
topic Gastroenterology, Hepatology
url http://dx.doi.org/10.1111/j.1440-1746.2007.05183.x