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Buchumschlag von CD147 promotes progression of head and neck squamous cell carcinoma via NF‐kappa B signaling
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CD147 promotes progression of head and neck squamous cell carcinoma via NF‐kappa B signaling

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Bibliographische Detailangaben
Zeitschriftentitel: Journal of Cellular and Molecular Medicine
Personen und Körperschaften: Yu, Binbin, Zhang, Yan, Wu, Kailiu, Wang, Lizhen, Jiang, Yingying, Chen, Wantao, Yan, Ming
In: Journal of Cellular and Molecular Medicine, 23, 2019, 2, S. 954-966
Medientyp: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
Cell Biology
Molecular Medicine
Details
Zusammenfassung: <jats:title>Abstract</jats:title><jats:p><jats:styled-content style="fixed-case">CD</jats:styled-content>147/basigin (<jats:styled-content style="fixed-case">BSG</jats:styled-content>) is highly upregulated in many types of cancer, our previous study has found that <jats:styled-content style="fixed-case">CD</jats:styled-content>147/<jats:styled-content style="fixed-case">BSG</jats:styled-content> is highly expressed in head and neck squamous cell carcinoma (<jats:styled-content style="fixed-case">HNSCC</jats:styled-content>) stem cells, but its role in <jats:styled-content style="fixed-case">HNSCC</jats:styled-content> and the underlying mechanism is still unknown. In this study, we investigated the role of <jats:styled-content style="fixed-case">CD</jats:styled-content>147 in the progression of <jats:styled-content style="fixed-case">HNSCC</jats:styled-content>. Real‐time <jats:styled-content style="fixed-case">PCR</jats:styled-content>, western blot and immunohistochemistry were used to detect the expression of <jats:styled-content style="fixed-case">CD</jats:styled-content>147 in total 189 <jats:styled-content style="fixed-case">HNSCC</jats:styled-content> tissues in compared with normal tissues. In addition, we used proliferation, colony formation, cell cycle and apoptosis, migration and invasion as well as wound‐healing assay to determine the biological roles of <jats:styled-content style="fixed-case">CD</jats:styled-content>147 in <jats:styled-content style="fixed-case">HNSCC</jats:styled-content>. Then, a xenograft model was performed to evaluate tumor‐promoting and metastasis‐promoting role of <jats:styled-content style="fixed-case">CD</jats:styled-content>147 in <jats:styled-content style="fixed-case">HNSCC</jats:styled-content>. The results showed that upregulated <jats:styled-content style="fixed-case">CD</jats:styled-content>147 expression was associated with aggressive clinicopathologic features in <jats:styled-content style="fixed-case">HNSCC</jats:styled-content>. In addition, <jats:styled-content style="fixed-case">CD</jats:styled-content>147 promoted proliferation, migration and reduced the apoptosis phenotype of <jats:styled-content style="fixed-case">HNSCC</jats:styled-content> cells in vitro as well as tumor initiation and progression in vivo. Furthermore, we demonstrated that <jats:styled-content style="fixed-case">CD</jats:styled-content>147 promoted <jats:styled-content style="fixed-case">HNSCC</jats:styled-content> progression through nuclear factor kappa B signaling. Therefore, we concluded that <jats:styled-content style="fixed-case">CD</jats:styled-content>147 promoted tumor progression in <jats:styled-content style="fixed-case">HNSCC</jats:styled-content> and might be a potential prognostic and treatment biomarker for <jats:styled-content style="fixed-case">HNSCC</jats:styled-content>.</jats:p>
Umfang: 954-966
ISSN: 1582-1838
1582-4934
DOI: 10.1111/jcmm.13996