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Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study
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Zeitschriftentitel: | Nutrients |
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Personen und Körperschaften: | , , , , , |
In: | Nutrients, 11, 2019, 7, S. 1610 |
Medientyp: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
MDPI AG
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Schlagwörter: |
author_facet |
Santiago-López, Lourdes Hernández-Mendoza, Adrián Vallejo-Cordoba, Belinda Mata-Haro, Verónica Wall-Medrano, Abraham González-Córdova, Aarón F. Santiago-López, Lourdes Hernández-Mendoza, Adrián Vallejo-Cordoba, Belinda Mata-Haro, Verónica Wall-Medrano, Abraham González-Córdova, Aarón F. |
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author |
Santiago-López, Lourdes Hernández-Mendoza, Adrián Vallejo-Cordoba, Belinda Mata-Haro, Verónica Wall-Medrano, Abraham González-Córdova, Aarón F. |
spellingShingle |
Santiago-López, Lourdes Hernández-Mendoza, Adrián Vallejo-Cordoba, Belinda Mata-Haro, Verónica Wall-Medrano, Abraham González-Córdova, Aarón F. Nutrients Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study Food Science Nutrition and Dietetics |
author_sort |
santiago-lópez, lourdes |
spelling |
Santiago-López, Lourdes Hernández-Mendoza, Adrián Vallejo-Cordoba, Belinda Mata-Haro, Verónica Wall-Medrano, Abraham González-Córdova, Aarón F. 2072-6643 MDPI AG Food Science Nutrition and Dietetics http://dx.doi.org/10.3390/nu11071610 <jats:p>The aim of this study was to evaluate the effect of milk fermented with Lactobacillus fermentum J20 (FMJ20) or J28 (FMJ28) on ameliorating indomethacin-induced inflammation. Twenty-eight male C57Bl/6 mice were divided into four experimental groups: indomethacin, indomethacin + FMJ20, indomethacin + FMJ28, and untreated (control). Groups were fed fermented milk for 15 days, followed by administration of indomethacin supplied in three sub-doses over experimental period. Body weight, and food consumption were recorded. Additionally, spleen, kidney, and liver were weighed, and the small intestine length was measured. The cytokines in serum (IL-2, IL-4, IL-6, IL-10, IL-17, IL-23 and TNFα) and in intestinal mucosa (IL-17 and IFNγ) were also determined. Compared to the control, all indomethacin-supplemented groups lost weight (~2.7 g; p < 0.05), but no changes were found in the organ-specific morphometry analysis. FMJ28 showed better results in attenuating serum and intestinal IL-17 levels. Furthermore, showed less epithelial cell loss and inflammatory infiltrates than the other indomethacin-treated groups. These results suggest that FMJ28 may be effective in reducing intestinal and systemic acute inflammation, specifically in mice.</jats:p> Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study Nutrients |
doi_str_mv |
10.3390/nu11071610 |
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Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft Medizin |
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2019 |
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Nutrients |
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49 |
title |
Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study |
title_unstemmed |
Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study |
title_full |
Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study |
title_fullStr |
Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study |
title_full_unstemmed |
Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study |
title_short |
Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study |
title_sort |
milk fermented with lactobacillus fermentum ameliorates indomethacin-induced intestinal inflammation: an exploratory study |
topic |
Food Science Nutrition and Dietetics |
url |
http://dx.doi.org/10.3390/nu11071610 |
publishDate |
2019 |
physical |
1610 |
description |
<jats:p>The aim of this study was to evaluate the effect of milk fermented with Lactobacillus fermentum J20 (FMJ20) or J28 (FMJ28) on ameliorating indomethacin-induced inflammation. Twenty-eight male C57Bl/6 mice were divided into four experimental groups: indomethacin, indomethacin + FMJ20, indomethacin + FMJ28, and untreated (control). Groups were fed fermented milk for 15 days, followed by administration of indomethacin supplied in three sub-doses over experimental period. Body weight, and food consumption were recorded. Additionally, spleen, kidney, and liver were weighed, and the small intestine length was measured. The cytokines in serum (IL-2, IL-4, IL-6, IL-10, IL-17, IL-23 and TNFα) and in intestinal mucosa (IL-17 and IFNγ) were also determined. Compared to the control, all indomethacin-supplemented groups lost weight (~2.7 g; p < 0.05), but no changes were found in the organ-specific morphometry analysis. FMJ28 showed better results in attenuating serum and intestinal IL-17 levels. Furthermore, showed less epithelial cell loss and inflammatory infiltrates than the other indomethacin-treated groups. These results suggest that FMJ28 may be effective in reducing intestinal and systemic acute inflammation, specifically in mice.</jats:p> |
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author | Santiago-López, Lourdes, Hernández-Mendoza, Adrián, Vallejo-Cordoba, Belinda, Mata-Haro, Verónica, Wall-Medrano, Abraham, González-Córdova, Aarón F. |
author_facet | Santiago-López, Lourdes, Hernández-Mendoza, Adrián, Vallejo-Cordoba, Belinda, Mata-Haro, Verónica, Wall-Medrano, Abraham, González-Córdova, Aarón F., Santiago-López, Lourdes, Hernández-Mendoza, Adrián, Vallejo-Cordoba, Belinda, Mata-Haro, Verónica, Wall-Medrano, Abraham, González-Córdova, Aarón F. |
author_sort | santiago-lópez, lourdes |
container_issue | 7 |
container_start_page | 0 |
container_title | Nutrients |
container_volume | 11 |
description | <jats:p>The aim of this study was to evaluate the effect of milk fermented with Lactobacillus fermentum J20 (FMJ20) or J28 (FMJ28) on ameliorating indomethacin-induced inflammation. Twenty-eight male C57Bl/6 mice were divided into four experimental groups: indomethacin, indomethacin + FMJ20, indomethacin + FMJ28, and untreated (control). Groups were fed fermented milk for 15 days, followed by administration of indomethacin supplied in three sub-doses over experimental period. Body weight, and food consumption were recorded. Additionally, spleen, kidney, and liver were weighed, and the small intestine length was measured. The cytokines in serum (IL-2, IL-4, IL-6, IL-10, IL-17, IL-23 and TNFα) and in intestinal mucosa (IL-17 and IFNγ) were also determined. Compared to the control, all indomethacin-supplemented groups lost weight (~2.7 g; p < 0.05), but no changes were found in the organ-specific morphometry analysis. FMJ28 showed better results in attenuating serum and intestinal IL-17 levels. Furthermore, showed less epithelial cell loss and inflammatory infiltrates than the other indomethacin-treated groups. These results suggest that FMJ28 may be effective in reducing intestinal and systemic acute inflammation, specifically in mice.</jats:p> |
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spelling | Santiago-López, Lourdes Hernández-Mendoza, Adrián Vallejo-Cordoba, Belinda Mata-Haro, Verónica Wall-Medrano, Abraham González-Córdova, Aarón F. 2072-6643 MDPI AG Food Science Nutrition and Dietetics http://dx.doi.org/10.3390/nu11071610 <jats:p>The aim of this study was to evaluate the effect of milk fermented with Lactobacillus fermentum J20 (FMJ20) or J28 (FMJ28) on ameliorating indomethacin-induced inflammation. Twenty-eight male C57Bl/6 mice were divided into four experimental groups: indomethacin, indomethacin + FMJ20, indomethacin + FMJ28, and untreated (control). Groups were fed fermented milk for 15 days, followed by administration of indomethacin supplied in three sub-doses over experimental period. Body weight, and food consumption were recorded. Additionally, spleen, kidney, and liver were weighed, and the small intestine length was measured. The cytokines in serum (IL-2, IL-4, IL-6, IL-10, IL-17, IL-23 and TNFα) and in intestinal mucosa (IL-17 and IFNγ) were also determined. Compared to the control, all indomethacin-supplemented groups lost weight (~2.7 g; p < 0.05), but no changes were found in the organ-specific morphometry analysis. FMJ28 showed better results in attenuating serum and intestinal IL-17 levels. Furthermore, showed less epithelial cell loss and inflammatory infiltrates than the other indomethacin-treated groups. These results suggest that FMJ28 may be effective in reducing intestinal and systemic acute inflammation, specifically in mice.</jats:p> Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study Nutrients |
spellingShingle | Santiago-López, Lourdes, Hernández-Mendoza, Adrián, Vallejo-Cordoba, Belinda, Mata-Haro, Verónica, Wall-Medrano, Abraham, González-Córdova, Aarón F., Nutrients, Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study, Food Science, Nutrition and Dietetics |
title | Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study |
title_full | Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study |
title_fullStr | Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study |
title_full_unstemmed | Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study |
title_short | Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study |
title_sort | milk fermented with lactobacillus fermentum ameliorates indomethacin-induced intestinal inflammation: an exploratory study |
title_unstemmed | Milk Fermented with Lactobacillus fermentum Ameliorates Indomethacin-Induced Intestinal Inflammation: An Exploratory Study |
topic | Food Science, Nutrition and Dietetics |
url | http://dx.doi.org/10.3390/nu11071610 |