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Yamamoto, Erin A. Nguyen, Jane K. Liu, Jessica Keller, Emma Campbell, Nicole Zhang, Cun-Jin Smith, Howard R. Li, Xiaoxia Jørgensen, Trine N Yamamoto, Erin A. Nguyen, Jane K. Liu, Jessica Keller, Emma Campbell, Nicole Zhang, Cun-Jin Smith, Howard R. Li, Xiaoxia Jørgensen, Trine N |
|---|---|
| author |
Yamamoto, Erin A. Nguyen, Jane K. Liu, Jessica Keller, Emma Campbell, Nicole Zhang, Cun-Jin Smith, Howard R. Li, Xiaoxia Jørgensen, Trine N |
| spellingShingle |
Yamamoto, Erin A. Nguyen, Jane K. Liu, Jessica Keller, Emma Campbell, Nicole Zhang, Cun-Jin Smith, Howard R. Li, Xiaoxia Jørgensen, Trine N Nutrients Low Levels of Vitamin D Promote Memory B Cells in Lupus Food Science Nutrition and Dietetics |
| author_sort |
yamamoto, erin a. |
| spelling |
Yamamoto, Erin A. Nguyen, Jane K. Liu, Jessica Keller, Emma Campbell, Nicole Zhang, Cun-Jin Smith, Howard R. Li, Xiaoxia Jørgensen, Trine N 2072-6643 MDPI AG Food Science Nutrition and Dietetics http://dx.doi.org/10.3390/nu12020291 <jats:p>Background: Vitamin D deficiency is a known risk factor for Systemic Lupus Erythematosus (SLE), yet clinical trials have not demonstrated efficacy and few studies have utilized lupus models to understand the mechanism underlying this relationship. The Act1-/- mouse is a spontaneous model of lupus and Sjögren’s syndrome, characterized by increased Th17 cells and peripheral B cell expansion. Vitamin D3 has anti-inflammatory properties, reduces Th17 cells and impairs B cell differentiation/activation. Therefore, we assessed how varying amounts of vitamin D3 affected lupus-like disease in the Act1-/- mouse. Methods: Act1-/- mice were fed either low/restricted (0 IU/kg), normal (2 IU/kg), or high/supplemented (10 IU/kg) vitamin D3 chow for 9 weeks, after which lupus-like features were analyzed. Results: While we found no differences in Th17 cells between vitamin D3 groups, vitamin D3 restriction specifically promoted memory B cell development, accompanied by elevated levels of serum IgM, IgG1, IgG3, and anti-dsDNA IgG. A similar significant negative association between serum vitamin D and memory B cells was confirmed in a cohort of SLE patients. Conclusion: Low levels of vitamin D3 are associated with elevated levels of memory B cells in an animal model of lupus and well-controlled SLE patients.</jats:p> Low Levels of Vitamin D Promote Memory B Cells in Lupus Nutrients |
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10.3390/nu12020291 |
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Online Free |
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Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft Medizin |
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MDPI AG, 2020 |
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MDPI AG, 2020 |
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Nutrients |
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| title |
Low Levels of Vitamin D Promote Memory B Cells in Lupus |
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Low Levels of Vitamin D Promote Memory B Cells in Lupus |
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Low Levels of Vitamin D Promote Memory B Cells in Lupus |
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Low Levels of Vitamin D Promote Memory B Cells in Lupus |
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Low Levels of Vitamin D Promote Memory B Cells in Lupus |
| title_short |
Low Levels of Vitamin D Promote Memory B Cells in Lupus |
| title_sort |
low levels of vitamin d promote memory b cells in lupus |
| topic |
Food Science Nutrition and Dietetics |
| url |
http://dx.doi.org/10.3390/nu12020291 |
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2020 |
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291 |
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<jats:p>Background: Vitamin D deficiency is a known risk factor for Systemic Lupus Erythematosus (SLE), yet clinical trials have not demonstrated efficacy and few studies have utilized lupus models to understand the mechanism underlying this relationship. The Act1-/- mouse is a spontaneous model of lupus and Sjögren’s syndrome, characterized by increased Th17 cells and peripheral B cell expansion. Vitamin D3 has anti-inflammatory properties, reduces Th17 cells and impairs B cell differentiation/activation. Therefore, we assessed how varying amounts of vitamin D3 affected lupus-like disease in the Act1-/- mouse. Methods: Act1-/- mice were fed either low/restricted (0 IU/kg), normal (2 IU/kg), or high/supplemented (10 IU/kg) vitamin D3 chow for 9 weeks, after which lupus-like features were analyzed. Results: While we found no differences in Th17 cells between vitamin D3 groups, vitamin D3 restriction specifically promoted memory B cell development, accompanied by elevated levels of serum IgM, IgG1, IgG3, and anti-dsDNA IgG. A similar significant negative association between serum vitamin D and memory B cells was confirmed in a cohort of SLE patients. Conclusion: Low levels of vitamin D3 are associated with elevated levels of memory B cells in an animal model of lupus and well-controlled SLE patients.</jats:p> |
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| author | Yamamoto, Erin A., Nguyen, Jane K., Liu, Jessica, Keller, Emma, Campbell, Nicole, Zhang, Cun-Jin, Smith, Howard R., Li, Xiaoxia, Jørgensen, Trine N |
| author_facet | Yamamoto, Erin A., Nguyen, Jane K., Liu, Jessica, Keller, Emma, Campbell, Nicole, Zhang, Cun-Jin, Smith, Howard R., Li, Xiaoxia, Jørgensen, Trine N, Yamamoto, Erin A., Nguyen, Jane K., Liu, Jessica, Keller, Emma, Campbell, Nicole, Zhang, Cun-Jin, Smith, Howard R., Li, Xiaoxia, Jørgensen, Trine N |
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| description | <jats:p>Background: Vitamin D deficiency is a known risk factor for Systemic Lupus Erythematosus (SLE), yet clinical trials have not demonstrated efficacy and few studies have utilized lupus models to understand the mechanism underlying this relationship. The Act1-/- mouse is a spontaneous model of lupus and Sjögren’s syndrome, characterized by increased Th17 cells and peripheral B cell expansion. Vitamin D3 has anti-inflammatory properties, reduces Th17 cells and impairs B cell differentiation/activation. Therefore, we assessed how varying amounts of vitamin D3 affected lupus-like disease in the Act1-/- mouse. Methods: Act1-/- mice were fed either low/restricted (0 IU/kg), normal (2 IU/kg), or high/supplemented (10 IU/kg) vitamin D3 chow for 9 weeks, after which lupus-like features were analyzed. Results: While we found no differences in Th17 cells between vitamin D3 groups, vitamin D3 restriction specifically promoted memory B cell development, accompanied by elevated levels of serum IgM, IgG1, IgG3, and anti-dsDNA IgG. A similar significant negative association between serum vitamin D and memory B cells was confirmed in a cohort of SLE patients. Conclusion: Low levels of vitamin D3 are associated with elevated levels of memory B cells in an animal model of lupus and well-controlled SLE patients.</jats:p> |
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| spelling | Yamamoto, Erin A. Nguyen, Jane K. Liu, Jessica Keller, Emma Campbell, Nicole Zhang, Cun-Jin Smith, Howard R. Li, Xiaoxia Jørgensen, Trine N 2072-6643 MDPI AG Food Science Nutrition and Dietetics http://dx.doi.org/10.3390/nu12020291 <jats:p>Background: Vitamin D deficiency is a known risk factor for Systemic Lupus Erythematosus (SLE), yet clinical trials have not demonstrated efficacy and few studies have utilized lupus models to understand the mechanism underlying this relationship. The Act1-/- mouse is a spontaneous model of lupus and Sjögren’s syndrome, characterized by increased Th17 cells and peripheral B cell expansion. Vitamin D3 has anti-inflammatory properties, reduces Th17 cells and impairs B cell differentiation/activation. Therefore, we assessed how varying amounts of vitamin D3 affected lupus-like disease in the Act1-/- mouse. Methods: Act1-/- mice were fed either low/restricted (0 IU/kg), normal (2 IU/kg), or high/supplemented (10 IU/kg) vitamin D3 chow for 9 weeks, after which lupus-like features were analyzed. Results: While we found no differences in Th17 cells between vitamin D3 groups, vitamin D3 restriction specifically promoted memory B cell development, accompanied by elevated levels of serum IgM, IgG1, IgG3, and anti-dsDNA IgG. A similar significant negative association between serum vitamin D and memory B cells was confirmed in a cohort of SLE patients. Conclusion: Low levels of vitamin D3 are associated with elevated levels of memory B cells in an animal model of lupus and well-controlled SLE patients.</jats:p> Low Levels of Vitamin D Promote Memory B Cells in Lupus Nutrients |
| spellingShingle | Yamamoto, Erin A., Nguyen, Jane K., Liu, Jessica, Keller, Emma, Campbell, Nicole, Zhang, Cun-Jin, Smith, Howard R., Li, Xiaoxia, Jørgensen, Trine N, Nutrients, Low Levels of Vitamin D Promote Memory B Cells in Lupus, Food Science, Nutrition and Dietetics |
| title | Low Levels of Vitamin D Promote Memory B Cells in Lupus |
| title_full | Low Levels of Vitamin D Promote Memory B Cells in Lupus |
| title_fullStr | Low Levels of Vitamin D Promote Memory B Cells in Lupus |
| title_full_unstemmed | Low Levels of Vitamin D Promote Memory B Cells in Lupus |
| title_short | Low Levels of Vitamin D Promote Memory B Cells in Lupus |
| title_sort | low levels of vitamin d promote memory b cells in lupus |
| title_unstemmed | Low Levels of Vitamin D Promote Memory B Cells in Lupus |
| topic | Food Science, Nutrition and Dietetics |
| url | http://dx.doi.org/10.3390/nu12020291 |