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An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2

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Bibliographische Detailangaben
Zeitschriftentitel: Journal of Biomimetics, Biomaterials and Tissue Engineering
Personen und Körperschaften: Zhou, Frank Y., Wei, Ai Qun, Diwan, Ashish D.
In: Journal of Biomimetics, Biomaterials and Tissue Engineering, 18, 2013, S. 97-118
Medientyp: E-Article
Sprache: Unbestimmt
veröffentlicht:
Trans Tech Publications, Ltd.
Schlagwörter:
author_facet Zhou, Frank Y.
Wei, Ai Qun
Diwan, Ashish D.
Zhou, Frank Y.
Wei, Ai Qun
Diwan, Ashish D.
author Zhou, Frank Y.
Wei, Ai Qun
Diwan, Ashish D.
spellingShingle Zhou, Frank Y.
Wei, Ai Qun
Diwan, Ashish D.
Journal of Biomimetics, Biomaterials and Tissue Engineering
An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
Biomedical Engineering
Bioengineering
Biotechnology
author_sort zhou, frank y.
spelling Zhou, Frank Y. Wei, Ai Qun Diwan, Ashish D. 1662-100X Trans Tech Publications, Ltd. Biomedical Engineering Bioengineering Biotechnology http://dx.doi.org/10.4028/www.scientific.net/jbbte.18.97 <jats:p>Intervertebral disc degeneration creates a significant healthcare burden on industrialized Western society. Recent research into treatment options has highlighted numerous biological strategies to replenish the native disc cells with minimal invasion, although their effectiveness and safety are still under intense investigation. This review provides an outline of the key biological therapies under research currently, including stem cells, biomaterial scaffolds and signaling molecules. Particularly, the focus will be on CDMP-2, a signaling molecule that has been found to possess properties that are therapeutic to disc degeneration. The review will assess the evidence of the molecule’s chondrogenic and chemotactic effects on disc cells and evaluate areas for further research in determining its regenerative potential in the intervertebral disc.</jats:p> An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 Journal of Biomimetics, Biomaterials and Tissue Engineering
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title An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
title_unstemmed An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
title_full An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
title_fullStr An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
title_full_unstemmed An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
title_short An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
title_sort an overview of intervertebral disc degeneration therapies and an evaluation of the chondrogenic and chemotactic potential of cdmp-2
topic Biomedical Engineering
Bioengineering
Biotechnology
url http://dx.doi.org/10.4028/www.scientific.net/jbbte.18.97
publishDate 2013
physical 97-118
description <jats:p>Intervertebral disc degeneration creates a significant healthcare burden on industrialized Western society. Recent research into treatment options has highlighted numerous biological strategies to replenish the native disc cells with minimal invasion, although their effectiveness and safety are still under intense investigation. This review provides an outline of the key biological therapies under research currently, including stem cells, biomaterial scaffolds and signaling molecules. Particularly, the focus will be on CDMP-2, a signaling molecule that has been found to possess properties that are therapeutic to disc degeneration. The review will assess the evidence of the molecule’s chondrogenic and chemotactic effects on disc cells and evaluate areas for further research in determining its regenerative potential in the intervertebral disc.</jats:p>
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author Zhou, Frank Y., Wei, Ai Qun, Diwan, Ashish D.
author_facet Zhou, Frank Y., Wei, Ai Qun, Diwan, Ashish D., Zhou, Frank Y., Wei, Ai Qun, Diwan, Ashish D.
author_sort zhou, frank y.
container_start_page 97
container_title Journal of Biomimetics, Biomaterials and Tissue Engineering
container_volume 18
description <jats:p>Intervertebral disc degeneration creates a significant healthcare burden on industrialized Western society. Recent research into treatment options has highlighted numerous biological strategies to replenish the native disc cells with minimal invasion, although their effectiveness and safety are still under intense investigation. This review provides an outline of the key biological therapies under research currently, including stem cells, biomaterial scaffolds and signaling molecules. Particularly, the focus will be on CDMP-2, a signaling molecule that has been found to possess properties that are therapeutic to disc degeneration. The review will assess the evidence of the molecule’s chondrogenic and chemotactic effects on disc cells and evaluate areas for further research in determining its regenerative potential in the intervertebral disc.</jats:p>
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spelling Zhou, Frank Y. Wei, Ai Qun Diwan, Ashish D. 1662-100X Trans Tech Publications, Ltd. Biomedical Engineering Bioengineering Biotechnology http://dx.doi.org/10.4028/www.scientific.net/jbbte.18.97 <jats:p>Intervertebral disc degeneration creates a significant healthcare burden on industrialized Western society. Recent research into treatment options has highlighted numerous biological strategies to replenish the native disc cells with minimal invasion, although their effectiveness and safety are still under intense investigation. This review provides an outline of the key biological therapies under research currently, including stem cells, biomaterial scaffolds and signaling molecules. Particularly, the focus will be on CDMP-2, a signaling molecule that has been found to possess properties that are therapeutic to disc degeneration. The review will assess the evidence of the molecule’s chondrogenic and chemotactic effects on disc cells and evaluate areas for further research in determining its regenerative potential in the intervertebral disc.</jats:p> An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 Journal of Biomimetics, Biomaterials and Tissue Engineering
spellingShingle Zhou, Frank Y., Wei, Ai Qun, Diwan, Ashish D., Journal of Biomimetics, Biomaterials and Tissue Engineering, An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2, Biomedical Engineering, Bioengineering, Biotechnology
title An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
title_full An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
title_fullStr An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
title_full_unstemmed An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
title_short An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
title_sort an overview of intervertebral disc degeneration therapies and an evaluation of the chondrogenic and chemotactic potential of cdmp-2
title_unstemmed An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
topic Biomedical Engineering, Bioengineering, Biotechnology
url http://dx.doi.org/10.4028/www.scientific.net/jbbte.18.97