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An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2
Gespeichert in:
Zeitschriftentitel: | Journal of Biomimetics, Biomaterials and Tissue Engineering |
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Personen und Körperschaften: | , , |
In: | Journal of Biomimetics, Biomaterials and Tissue Engineering, 18, 2013, S. 97-118 |
Medientyp: | E-Article |
Sprache: | Unbestimmt |
veröffentlicht: |
Trans Tech Publications, Ltd.
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Schlagwörter: |
author_facet |
Zhou, Frank Y. Wei, Ai Qun Diwan, Ashish D. Zhou, Frank Y. Wei, Ai Qun Diwan, Ashish D. |
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author |
Zhou, Frank Y. Wei, Ai Qun Diwan, Ashish D. |
spellingShingle |
Zhou, Frank Y. Wei, Ai Qun Diwan, Ashish D. Journal of Biomimetics, Biomaterials and Tissue Engineering An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 Biomedical Engineering Bioengineering Biotechnology |
author_sort |
zhou, frank y. |
spelling |
Zhou, Frank Y. Wei, Ai Qun Diwan, Ashish D. 1662-100X Trans Tech Publications, Ltd. Biomedical Engineering Bioengineering Biotechnology http://dx.doi.org/10.4028/www.scientific.net/jbbte.18.97 <jats:p>Intervertebral disc degeneration creates a significant healthcare burden on industrialized Western society. Recent research into treatment options has highlighted numerous biological strategies to replenish the native disc cells with minimal invasion, although their effectiveness and safety are still under intense investigation. This review provides an outline of the key biological therapies under research currently, including stem cells, biomaterial scaffolds and signaling molecules. Particularly, the focus will be on CDMP-2, a signaling molecule that has been found to possess properties that are therapeutic to disc degeneration. The review will assess the evidence of the molecule’s chondrogenic and chemotactic effects on disc cells and evaluate areas for further research in determining its regenerative potential in the intervertebral disc.</jats:p> An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 Journal of Biomimetics, Biomaterials and Tissue Engineering |
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2013 |
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Trans Tech Publications, Ltd. |
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ai |
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Journal of Biomimetics, Biomaterials and Tissue Engineering |
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title |
An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 |
title_unstemmed |
An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 |
title_full |
An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 |
title_fullStr |
An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 |
title_full_unstemmed |
An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 |
title_short |
An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 |
title_sort |
an overview of intervertebral disc degeneration therapies and an evaluation of the chondrogenic and chemotactic potential of cdmp-2 |
topic |
Biomedical Engineering Bioengineering Biotechnology |
url |
http://dx.doi.org/10.4028/www.scientific.net/jbbte.18.97 |
publishDate |
2013 |
physical |
97-118 |
description |
<jats:p>Intervertebral disc degeneration creates a significant healthcare burden on industrialized Western society. Recent research into treatment options has highlighted numerous biological strategies to replenish the native disc cells with minimal invasion, although their effectiveness and safety are still under intense investigation. This review provides an outline of the key biological therapies under research currently, including stem cells, biomaterial scaffolds and signaling molecules. Particularly, the focus will be on CDMP-2, a signaling molecule that has been found to possess properties that are therapeutic to disc degeneration. The review will assess the evidence of the molecule’s chondrogenic and chemotactic effects on disc cells and evaluate areas for further research in determining its regenerative potential in the intervertebral disc.</jats:p> |
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author | Zhou, Frank Y., Wei, Ai Qun, Diwan, Ashish D. |
author_facet | Zhou, Frank Y., Wei, Ai Qun, Diwan, Ashish D., Zhou, Frank Y., Wei, Ai Qun, Diwan, Ashish D. |
author_sort | zhou, frank y. |
container_start_page | 97 |
container_title | Journal of Biomimetics, Biomaterials and Tissue Engineering |
container_volume | 18 |
description | <jats:p>Intervertebral disc degeneration creates a significant healthcare burden on industrialized Western society. Recent research into treatment options has highlighted numerous biological strategies to replenish the native disc cells with minimal invasion, although their effectiveness and safety are still under intense investigation. This review provides an outline of the key biological therapies under research currently, including stem cells, biomaterial scaffolds and signaling molecules. Particularly, the focus will be on CDMP-2, a signaling molecule that has been found to possess properties that are therapeutic to disc degeneration. The review will assess the evidence of the molecule’s chondrogenic and chemotactic effects on disc cells and evaluate areas for further research in determining its regenerative potential in the intervertebral disc.</jats:p> |
doi_str_mv | 10.4028/www.scientific.net/jbbte.18.97 |
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physical | 97-118 |
publishDate | 2013 |
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publisher | Trans Tech Publications, Ltd. |
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recordtype | ai |
series | Journal of Biomimetics, Biomaterials and Tissue Engineering |
source_id | 49 |
spelling | Zhou, Frank Y. Wei, Ai Qun Diwan, Ashish D. 1662-100X Trans Tech Publications, Ltd. Biomedical Engineering Bioengineering Biotechnology http://dx.doi.org/10.4028/www.scientific.net/jbbte.18.97 <jats:p>Intervertebral disc degeneration creates a significant healthcare burden on industrialized Western society. Recent research into treatment options has highlighted numerous biological strategies to replenish the native disc cells with minimal invasion, although their effectiveness and safety are still under intense investigation. This review provides an outline of the key biological therapies under research currently, including stem cells, biomaterial scaffolds and signaling molecules. Particularly, the focus will be on CDMP-2, a signaling molecule that has been found to possess properties that are therapeutic to disc degeneration. The review will assess the evidence of the molecule’s chondrogenic and chemotactic effects on disc cells and evaluate areas for further research in determining its regenerative potential in the intervertebral disc.</jats:p> An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 Journal of Biomimetics, Biomaterials and Tissue Engineering |
spellingShingle | Zhou, Frank Y., Wei, Ai Qun, Diwan, Ashish D., Journal of Biomimetics, Biomaterials and Tissue Engineering, An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2, Biomedical Engineering, Bioengineering, Biotechnology |
title | An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 |
title_full | An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 |
title_fullStr | An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 |
title_full_unstemmed | An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 |
title_short | An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 |
title_sort | an overview of intervertebral disc degeneration therapies and an evaluation of the chondrogenic and chemotactic potential of cdmp-2 |
title_unstemmed | An Overview of Intervertebral Disc Degeneration Therapies and an Evaluation of the Chondrogenic and Chemotactic Potential of CDMP-2 |
topic | Biomedical Engineering, Bioengineering, Biotechnology |
url | http://dx.doi.org/10.4028/www.scientific.net/jbbte.18.97 |